| 000 | 07964nam a22004573i 4500 | ||
|---|---|---|---|
| 001 | EBC3377964 | ||
| 003 | MiAaPQ | ||
| 005 | 20240729125320.0 | ||
| 006 | m o d | | ||
| 007 | cr cnu|||||||| | ||
| 008 | 240724s1982 xx o ||||0 eng d | ||
| 020 |
_a9780309593786 _q(electronic bk.) |
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| 020 | _z9780309077590 | ||
| 035 | _a(MiAaPQ)EBC3377964 | ||
| 035 | _a(Au-PeEL)EBL3377964 | ||
| 035 | _a(CaPaEBR)ebr10085524 | ||
| 035 | _a(OCoLC)923274692 | ||
| 040 |
_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ |
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| 050 | 4 | _aRM323.3.A68 1982 | |
| 245 | 1 | 0 |
_aPossible Long-Term Health Effects of Short-Term Exposure to Chemical Agents : _bVolume 1. |
| 250 | _a1st ed. | ||
| 264 | 1 |
_aWashington, D.C. : _bNational Academies Press, _c1982. |
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| 264 | 4 | _c©1982. | |
| 300 | _a1 online resource (298 pages) | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 505 | 0 | _aPOSSIBLE LONG-TERM HEALTH EFFECTS OF SHORT-TERM EXPOSURE TO CHEMICAL AGENTS -- Copyright -- ACKNOWLEDGEMENTS -- PREFACE -- EXECUTIVE SUMMARY -- ANTICHOLINESTERASE CHEMICALS -- ANTICHOLINERGIC CHEMICALS -- MORTALITY -- MORBIDITY -- Contents -- 1 INTRODUCTION -- HISTORY OF THE EDGEWOOD TESTING PROGRAM -- PROCEDURES USED AT THE EDGEWOOD CHEMICAL TESTING PROGARM -- RECRUITMENT OF VOLUNTEERS -- GUIDELINES FOLLOWED IN THE PROTECTION OF SUBJECTS -- INVESTIGATORS -- SELECTION OF DOSES FOR HUMAN TESTS -- RANGE OF DOSES -- SAFETY MARGIN -- 2 ANTICHOLINESTERASES -- CHEMISTRY OF ANTICHOLINESTERASES -- "REVERSIBLE" INHIBITORS -- ORGANOPHOSPHORUS (OP) INHIBITORS -- ABSORPTION, FATE, AND EXCRETION OF ANTI-CHES -- MECHANISMS OF ACTION -- INHIBITION OF ACETYLCHOLINESTERASE BY ANTICHOLINESTERASES -- REACTIVATION OF ACHE -- AGING OF INHIBITED ACHE -- CHOLINERGIC RECEPTOR AND ACH CHANNEL -- PRESYNAPTIC ACTION -- NERVE MEMBRANE -- CENTRAL NERVOUS SYSTEM -- "NEUROTOXIC" ESTERASE (NTE) -- BIOCHEMICAL AND METABOLIC CHANGES -- OP ALKYLATION -- BIOLOGIC AND CLINICAL EFFECTS -- ACUTE EFFECTS: PHARMACOLOGY -- Eye -- Gastrointestinal Tract -- Actions at Other Autonomic Sites -- Neuromuscular Junction -- Brain -- ACUTE TOXIC EFFECTS -- DELAYED NEUROPATHY (CNS-PNS DISTAL AXONOPATHY) -- Clinical Features -- Neuropathologic Features -- Neuropathic Potency -- LONG-TERM BRAIN DYSFUNCTION -- JUNCTIONAL NEUROMYOPATHY -- OTHER ADVERSE HEALTH EFFECTS -- Mutagenicity -- Carcinogenicity -- Fetal and Teratogenic Effects -- Effects on Male Reproduction -- Cataractogenic Effects -- Hemocoagulation -- IMMEDIATE AND DELAYED EFFECTS IN VOLUNTEERS AFTER SINGLE OR REPEATED EXPOSURE TO ANTI-CHES AT EDGEWOOD -- MORTALITY DATA -- EVALUATION OF THE LIKELIHOOD OF LONG-TERM ADVERSE HEALTH EFFECTS -- BRAIN DYSFUNCTION -- JUNCTIONAL NEUROMYOPATHY AND DELAYED NEUROPATHY -- OTHER ADVERSE HEALTH EFFECTS. | |
| 505 | 8 | _aMutagenicity, Carcinogenicity, and Male Reproductive Effects -- Cataractogenicity -- Blood Changes -- CONCLUSIONS -- REFERENCES -- 3 ANTICHOLINERGICS -- ATROPINE, SCOPOLAMINE, AND RELATED THERAPEUTIC ANTICHOLINERGIC CHEMICALS -- SITES OF ACTION -- PERIPHERAL EFFECTS -- CENTRAL EFFECTS -- POISONING BY BELLADONNA ALKALOIDS -- SYMPTOMS AND SIGNS OF ATROPINE POISONING -- TREATMENT -- MECHANISM OF ACTION -- ABSORPTION, FATE, AND EXCRETION -- PHARMACOLOGICAL PROPERTIES OF SYNTHETIC ATROPINE DERIVATIVES -- ROLE OF DRUG DISPOSITION IN EXPLAINING DIFFERENCES AMONG ANTICHOLINERGIC COMPOUNDS -- ATROPINE -- BZ -- ANIMAL TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS -- IMMEDIATE EFFECTS -- EA 3443 -- EA 3834 -- LONG-TERM AND DELAYED EFFECTS -- Atropine -- Clidinium (Quartzan) -- Other Data -- HUMAN TOXICOLOGY OF ANTICHOLINERGIC COMPOUNDS -- DOSING CONSIDERATIONS -- Atropine -- Other Anticholinergic Compounds -- USE OF ANTIDOTES -- IMMEDIATE EFFECTS -- Peripheral and Behavioral Effects -- EEG Effects -- BZ Case Reports -- EA 3834 -- Overall Evaluation of Immediate Adverse Effects -- LONG-TERM AND DELAYED EFFECTS -- MORTALITY -- SUMMARY -- CONCLUSIONS -- REFERENCES -- 4 MORTALITY -- METHOD OF ANALYSIS -- RESULTS -- REFERENCE -- APPENDIX A MASTER FILE-ANTICHOLINESTERASE CHEMICALS -- APPENDIX B MASTER FILE-ANTICHOLINERGIC CHEMICALS -- APPENDIX C LIST OF DOCUMENTS SUPPLIED TO ANTICHOLINESTERASE PANEL -- APPENDIX D LIST OF DOCUMENTS SUPPLIED TO ANTICHOLINERGIC PANEL -- APPENDIX E CASE-FILE DATA ON EDGEWOOD SUBJECTS -- SUMMARY OF VOLUNTEER TESTING WITH GB (A1) -- SUMMARY OF VOLUNTEER TESTING WITH VX (A2) -- SUMMARY OF VOLUNTEER TESTING WITH GA (A3) -- SUMMARY OF VOLUNTEER TESTING WITH GD (A5) -- SUMMARY OF VOLUNTEER TESTING WITH DFP (A6) -- SUMMARY OF VOLUNTEER TESTING WITH EA 3148 (A7) -- SUMMARY OF VOLUNTEER TESTING WITH THA (A9), TACRINE. | |
| 505 | 8 | _aSUMMARY OF VOLUNTEER TESTING WITH PHYSOSTIGMINE (A10) -- SUMMARY OF VOLUNTEER TESTING WITH PROSTIGMINE (A11) -- SUMMARY OF VOLUNTEER TESTING WITH HEXAFLUORENIUM (MYLAXINR) (A12) -- SUMMARY OF VOLUNTEER TESTING WITH MALATHION (A14) -- SUMMARY OF VOLUNTEER TESTING WITH METHACHOLINE (A20) -- SUMMARY OF VOLUNTEER TESTING WITH URECHOLINE (A21) -- APPENDIX F EXCERPTS FROM BZ DATA -- CONTENTS -- APPENDIX G SUMMARY OF ACUTE-AND CHRONIC-TOXICITY DATA IN VARIOUS MAMMALS WITH THE ANTICHOLINERGIC TEST AGENTS (DITRAN,… -- TOXICITY -- BLOOD (RATS) -- HISTOPATHOLOGY -- OTHER DRUGS -- CONCLUSION -- APPENDIX H EVALUATION OF DATA FROM SHORT-TERM GENETIC TESTING OF ANTICHOLINERGIC CHEMICALS -- 3-QUINUCLIDINYL BENZILATE -- SCOPOLAMINE -- ATROPINE -- CONCLUSIONS -- REFERENCES -- APPENDIX I DIGEST REPORT-ANTICHOLINERGIC CHEMICALS -- INTRODUCTION -- APPENDIX I DIGEST REPORT ANTICHOLINERGIC CHEMICALS -- INTRODUCTION -- ESTERS OF TROPIC ACID -- STUDIES IN ANIMALS -- HUMAN DATA FROM THE GENERAL LITERATURE -- HUMAN DATA FROM EDGEWOOD ARSENAL -- SUMMARY -- ESTERS OF BENZILIC ACID -- STUDIES IN ANIMALS -- 3-QUINUCLIDINYL BENZILATE (BZ, EA 2277) -- DIETHYLAMINOETHYL BENZILATE -- EFFECTS ON MAN -- SUMMARY -- ESTERS OF PHENYLCYCLOPENTYLGLYCOLIC ACID -- N-METHYL-4-PIPERIDINYL-(PHENYLCYCLOPENTYL)-GLYCOLATE (EA 3443) -- DITRAN (CS 4297) -- 3-QUINUCLIDINYL-(PHENYLCYCLOPENTYL)-GLYCOLATE (EA 3167) -- L-2-ALPHA-TROPINYL-L-(PHENYLCYCLOPENTYL)-GLYCOLATE (226,086) -- 2-METHYL-3-QUINUCLIDINYL-(PHENYLCYCLOPENTYL)-GLYCOLATE (301,060) -- ESTERS OF PHENYLISOPROPYLGLYCOLIC ACID -- N-METHYL-4-PIPERIDINYL-(PHENYLISOPROPYL)-GLYCOLATE (EA 3834) -- 4-(1-METHYL-1,2,3,6-TETRAHYDROPYRIDINYL)-PHENYLISOPROPYLGLYCOLATE (302,668) -- ESTERS OF 1-PROPYNYLCYCLOPENTYLGLYCOLIC ACID -- N-METHYL-4-PIPERIDYL-(PHENYLCYCLOBUTYL)-GLYCOLATE (EA 3580) -- MISCELLANEOUS ESTERS -- 302,282 -- 302,537 -- WIN2299. | |
| 505 | 8 | _aNONESTER ANTICHOLINERGIC COMPOUNDS -- BENZETIMIDE -- MEPIPERPHENIDOL -- "TAB" MIXTURE -- DISCUSSION -- REFERENCES -- APPENDIX J ANTICHOLINERGIC DRUGS AND THE EEG -- LITERATURE REVIEW -- MILITARY DATA -- Conclusions -- REFERENCES -- APPENDIX K BIOCHEMICAL ASPECTS OF ANTICHOLINERGIC CHEMICALS -- CONCLUSION -- REFERENCES -- APPENDIX L STRUCTURE-ACTIVITY RELATIONS OF THE CENTRALLY ACTIVE ANTICHOLINERGIC AGENTS -- STEREOSPECIFICITY -- COMPARISON OF ANIMAL AND HUMAN DATA WITH VARIOUS ANTICHOLINERGIC DRUGS -- SITES OF ANTICHOLINERGIC ACTION IN BRAIN -- COMPETITION BETWEEN BEHAVIORAL POTENCY AND RECEPTOR AFFINITY -- REFERENCES. | |
| 588 | _aDescription based on publisher supplied metadata and other sources. | ||
| 590 | _aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. | ||
| 650 | 0 | _aChemical warfare. | |
| 650 | 0 | _aCholinesterase inhibitors. | |
| 650 | 0 | _aParasympatholytic agents. | |
| 655 | 4 | _aElectronic books. | |
| 776 | 0 | 8 |
_iPrint version: _a _tPossible Long-Term Health Effects of Short-Term Exposure to Chemical Agents _dWashington, D.C. : National Academies Press,c1982 _z9780309077590 |
| 797 | 2 | _aProQuest (Firm) | |
| 856 | 4 | 0 |
_uhttps://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3377964 _zClick to View |
| 999 |
_c85267 _d85267 |
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