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001			EBC3020631
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005			20240729124139.0
006			m o d |
007			cr cnu||||||||
008			240724s2013 xx o ||||0 eng d
020			_a9781624178078 _q(electronic bk.)
020			_z9781624178061
035			_a(MiAaPQ)EBC3020631
035			_a(Au-PeEL)EBL3020631
035			_a(CaPaEBR)ebr10678036
035			_a(OCoLC)846919531
040			_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ
050		4	_aRC931.O73.O88 2013
100	1		_aScheurer, Hugo.
245	1	0	_aOsteoblasts : _bMorphology, Functions and Clinical Implications.
250			_a1st ed.
264		1	_aHauppauge : _bNova Science Publishers, Incorporated, _c2013.
264		4	_c©2013.
300			_a1 online resource (155 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aCell Biology Research Progress
505	0		_aIntro -- OSTEOBLASTS -- OSTEOBLASTS -- Contents -- Preface -- Osteoblasts under Mechanical Strain -- Abstract -- Abbreviations -- 1. Introduction -- 1.1. Bone Tissue Cellular Structure -- 1.2. Osteoblasts -- 1.2.1. Osteoblast Origin and Life Cycle -- 1.2.2. Osteoblast Function -- 1.2.3. Growth Factor and Hormone Effects on Osteoblasts -- 1.3. Runx2 Transcription Factor in Bone Biology -- 1.3.1. Runx2 in Osteoblast Differentiation -- 1.3.2. Structure of Runx2 Gene -- 1.3.3. Runx2 Expression -- 2. Bone Remodeling -- 2.1. Regulation of Bone Remodeling -- 2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling -- 2.3. Bone Remodeling Pathophysiology -- 3. Mechanotransduction -- 3.1. Bone Remodeling and Mechanotransduction -- 3.2. Runx2 in Mechanotransduction -- 3.3. Nuclear Factor Κappa B (NF-κΒ) Transcription Factor in Mechanotransduction -- 3.4. Polycystins in Mechanotransduction -- 3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts -- 3.6. The Role of Mechanotransduction in Bone Disease -- 3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease -- Conclusion -- References -- From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering -- Abstract -- Introduction -- Mesenchymal Stem Cells -- Differentiation of MSC into Osteoblast -- Role of Growth Factors and Transcription Factors in Osteoblast Differentiation -- Role of Transcription Factor in Differentiation of Osteoblast -- Scaffolds -- Natural Scaffolds: Extracellular Matrix -- Glycosaminoglycans (GAGs) -- Chitosan Scaffold -- Tripolymer Scaffolds -- References -- Osteoblast Functions and their Role in Skeletal Bone Diseases -- Abstract -- Introduction -- Osteoblast Lineage and Differentiation -- Transcription Factors, Signaling Proteins and Osteoblast Differentiation -- Osteoblast Migration -- Osteoblasts and Bone Diseases.
505	8		_aOsteoporosis -- Osteoarthritis -- Osteogenesis Imperfecta -- Van Buchem Disease and Sclerosteosis -- Oculodentodigital Dysplasia -- Camurati-Engelmann Disease -- Cleidocranial Dysplaysia -- Osteoblastic Bone Metastasis -- Acknowledgment -- References -- Osteoblast Differentiation and Related Diseases -- Abstract -- Introduction -- A. Transcription Factors Regulating Osteoblast Differentiation -- RUNX2 -- TWIST1 -- MSX1 and MSX2 -- SP7/Osterix -- β-Catenin -- ATF4 -- FoxO1 -- B. Diseases Associated with Osteogenic Transcription Factors -- Cleidocranial Dysplasia (CCD) -- Saethre Chotzen Syndrome (SCS) -- Boston-Type Craniosynostosis -- Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation -- Coffin-Lowry Syndrome (CLS) -- Neurofibromatosis Type I -- Conclusion -- References -- BMP and Osteoblastogenesis Inhibitors -- Abstract -- Bone Morphogenetic Proteins -- BMP-Smad Signaling -- Extracellular Inhibitor -- Cytomembrane Inhibitors -- Intracellular Inhibitors -- Nuclear Inhibitors, Which Interact with Runx2 or Osx -- MicroRNAs -- Prospect for Future Therapy -- References -- The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation -- Abstract -- Introduction -- Osteoblast Differentiation and Inducer Materials -- Standard Medium for Osteogenic Cultures -- Medium Supplements -- Ascorbic Acid -- 1. The Effect of Ascorobic Acid on Osteoclast Formation -- 2.The Effect of Ascorbic Acid on Osteoblast Formation -- B-Glycerophosphate (BGP) -- Dexamethasone (Dex) -- Vitamin D3 -- Bone Morphogenic Protein 2(BMP-2) -- Collagen I and Vetronectin -- Conclusion and Further Remarks -- References -- Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization -- Abstract -- Introduction -- Characteristics of Osteblast -- Bone Morphogenetic Protein (BMP) -- Various Agents.
505	8		_aLaboratory Experiments -- (1) Cellular Proliferation -- (2) Alkaline Phosphatase Activity Assays (ALP) -- (3) Mineralization Assay -- Conclusion -- References -- Index.
588			_aDescription based on publisher supplied metadata and other sources.
590			_aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
650		0	_aOsteoporosis.
655		4	_aElectronic books.
776	0	8	_iPrint version: _aScheurer, Hugo _tOsteoblasts: Morphology, Functions and Clinical Implications _dHauppauge : Nova Science Publishers, Incorporated,c2013 _z9781624178061
797	2		_aProQuest (Firm)
830		0	_aCell Biology Research Progress
856	4	0	_uhttps://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3020631 _zClick to View
999			_c60943 _d60943