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| 001 | EBC5491306 | ||
| 003 | MiAaPQ | ||
| 005 | 20240724113318.0 | ||
| 006 | m o d | | ||
| 007 | cr cnu|||||||| | ||
| 008 | 240724s2018 xx o ||||0 eng d | ||
| 020 |
_a9781681083377 _q(electronic bk.) |
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| 020 | _z9781681083384 | ||
| 035 | _a(MiAaPQ)EBC5491306 | ||
| 035 | _a(Au-PeEL)EBL5491306 | ||
| 035 | _a(OCoLC)1048922805 | ||
| 040 |
_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ |
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| 050 | 4 | _aRC48 .F766 2018 | |
| 082 | 0 | _a616 | |
| 100 | 1 | _aAtta-ur-Rahman. | |
| 245 | 1 | 0 |
_aFrontiers in Clinical Drug Research - Anti-Allergy Agents : _bVolume 3. |
| 250 | _a1st ed. | ||
| 264 | 1 |
_aSharjah : _bBentham Science Publishers, _c2018. |
|
| 264 | 4 | _c©2018. | |
| 300 | _a1 online resource (257 pages) | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 |
_aFrontiers in Clinical Drug Research - Anti-Allergy Agents Series ; _vv.3 |
|
| 505 | 0 | _aIntro -- CONTENTS -- PREFACE -- List of Contributors -- Developing the Perfect Antihistamine for Use in Allergic Conditions: A Voyage in H1 Selectivity -- Diana R. Cundell* and Kathryn E. Mickle -- INTRODUCTION -- Pharmacology of Histamine -- Cellular Sources of Histamine and Mechanisms of Release -- Mast Cells and the Inflammatory Environment -- Histamine and Body Tissues -- Antihistamines for the Treatment of Allergies -- Nasal Anatomy and Physiology, Allergic Rhinitis, Allergens and Histamine -- Allergens and Allergic Rhinitis -- The Eye Conjunctiva -- Anatomy And Physiology, Allergic Conjunctivitis and Histamine -- Allergens and Allergic Conjunctivitis -- The Skin -- Anatomy and Physiology, Urticaria and Histamine -- Allergens and Urticaria -- Histamine and the H1 Receptor -- First Generation H1 Antihistamines -- A History of First Generation Antihistamine Development -- Ethylenediamines and Ethanolamines -- Piperazines and Piperidines -- Phenothiazines and Doxepin -- A New Genre of Antihistamines With Powerful Central Nervous System Effects -- Side Effects of The First Generation H1 Antihistamines and Toxicity -- Central Nervous System H1 Side Effects -- Adverse Effects of First Generation H1 Antihistamines Due to Lack of Selectivity -- Toxicity of First Generation Antihistamines -- Second Generation H1 Antihistamines -- Safer with Less Side Effects -- Second Generation Antihistamines With Significant Side Effects: Astemizole, Azelastine and Terfenadine -- Second Generation Histamines That are First Generation Analogs -- Acrivastine, Cetirizine and Levocetirizine -- Cetirizine -- Levocetirizine -- Second Generation Piperidine Successes -- Levocabastine, Loratadine, Desloratadine, Fexofenadine, and Olopatadine -- Loratadine -- Desloratadine -- Fexofenadine -- Olopatadine. | |
| 505 | 8 | _aClinical Trial Meta-Analysis Data for Extensively Used Second Generation Antihistamines -- CONCLUSION AND FURTHER DIRECTIONS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Therapeutics in Chronic Spontaneous Urticaria -- Alexei Gonzalez-Estrada* and James Fernandez -- INTRODUCTION -- TREATMENT -- ANTIHISTAMINES -- H1-Antihistamines -- FIRST-GENERATION H1-ANTIHISTAMINES -- Hydroxyzine -- Doxepin -- SECOND-GENERATION H1-ANTIHISTAMINES -- Cetirizine -- Desloratadine -- Loratadine -- Fexofenadine -- Levocetirizine -- Rupatadine -- H2-Antihistamines -- Cimetidine -- Ranitidine -- Famotidine -- Leukotriene Antagonist -- Montelukast -- Zafirlukast -- IMMUNOSUPPRESSIVE MEDICATIONS FOR CSU -- Hydroxychloroquine -- Colchicine -- Dapsone -- Sulfasalazine -- Methotrexate -- Cyclosporine -- IMMUNOMODULATORY AGENTS -- Omalizumab -- Intravenous Immunoglobulin -- Corticosteroids -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Research and Development for Anti-Asthmatic Agents with a Focus on Phenotype Changing by Ca2+ Signaling in Airway Smooth Muscle Cells -- Hiroaki Kume1,2,* -- INTRODUCTION -- MECHANISM OF AIRWAY SMOOTH MUSCLE TONE -- AIRWAY SMOOTH MUSCLE TONE REGULATED BY KCA CHANNELS -- Characteristics and physiological roles of KCa channels -- Structure of KCa Channels -- Electrical Characteristics of KCa Channels -- Physiological Role of KCa Channels -- Stimulatory Regulation of KCa Channels by β2-Adrenoceptor Agonists -- cAMP-Dependent Phosphorylation -- Membrane-Delimited Activation by Gs -- Dual Regulation by cAMP-Dependent and -Independent Processes -- Role in Relaxation by β2-Adrenoceptor Agonists -- Inhibitory Regulation of KCa Channels by Muscarinic Receptor Agonists -- Membrane-Delimited Inhibition by Gi -- Dual Regulation by Gs and Gi. | |
| 505 | 8 | _aRole in Contraction by Muscarinic Receptor Agonists -- Regulation of KCa Channels by other Factors (cGMP, Protein Kinase C) -- AIRWAY SMOOTH MUSCLE TONE REGULATED BY CA2+ DYNAMICS -- Membrane Potential-Independent Ca2+ Dynamics -- Membrane Potential-dependent Ca2+ Dynamics -- Effects of Ca2+ Release from the SR -- AIRWAY SMOOTH MUSCLE TONE REGULATED BY CA2+ SENSITIZATION -- Characteristics and Physiological Role of RhoA / Rho-kinase -- Role of RhoA / Rho-kinase on Contraction -- Role on β2-Adrenergic Relaxation -- INTRINSIC EFFICACY OF Β2-ADRENOCEPTOR AGONISTS -- Characteristics and Measurement -- Values of β2-Adrenergic Intrinsic Efficacy for Airway Smooth Muscle Relaxation -- Effects of Intrinsic Efficacy on β2-Adrenegic Desensitization -- Role of Allosteric GPCR Modulation in Intrinsic Efficacy -- ROLE OF CA2+ SIGNALING IN AIRWAY DISORDERS -- Airflow Limitation (Bronchoconstriction) -- Airway Hyperresponsiveness -- Desensitization of β2- Adrenoceptors -- Ca2+ Dynamics -- Ca2+ Sensitization -- Airway Remodeling -- Cell Proliferation -- Cell Migration -- Interaction between Airway Smooth Muscle and Inflammatory Cells -- PHENOTYPE PLASTICITY -- Contractile phenotype -- Synthetic and Proliferative Phenotypes -- Hyper-Contractile Phenotype -- Ca2+ Handling -- Regulation of Phenotype Switching -- Modulation of Cell Phenotype by Cell Culture -- RATIONALE USE OF Β2-ADRENOCEPTOR AGONISTS BASED ON THEIR INTRINSIC EFFICACY -- SYNERGISTIC EFFECTS BETWEEN MUSCARINIC AND Β2-ADRENERGIC RECEPTORS -- Role of G proteins / KCa Channels Linkage -- Role of Allosteric GPCR Modulation in Synergistic Effects -- POSSIBLE EFFECTS OF BRONCHODILATORS ON AIRWAY INFLAMMATION -- CONCLUSIONS -- ABBREVIATION -- CONSENT FOR PUBLICATION -- ACKNOWLEDGEMENT -- CONFLICT OF INTEREST STATEMENT -- REFERENCES -- Effects of Allergic Rhinitis on Communication Skills. | |
| 505 | 8 | _aCan Cemal Cingi1,*, Erkan Yüksel2 and Nuray Bayar Muluk3 -- 1. INTRODUCTION -- 2. EFFECTS OF ALLERGIC RHINITIS ON HUMAN RELATIONS -- 2.1. Psychological Effects -- 2.2. Physiological Effects -- 2.3. Behavioral Effects -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Endosomal Toll-like Receptors: Rheostats of Inflammation and Diseases -- Chhedi Lal Gupta, Rohit Kumar Tiwari, Neelam Pathak and Preeti Bajpai* -- AN OVERVIEW -- Toll-like Receptors -- Structure of Toll-like Receptors -- Toll-like Receptor Signaling -- ENDOSOMAL TOLL-LIKE RECEPTORS -- Ligand Detection by Endosomal TLRs -- dsRNA Detection by TLR3 -- ssRNA Detection by TLR7 and TLR8 -- CpG DNA Detection by TLR9 -- Endosomal TLRs in Disease Aggravation -- Role of Endosomal TLRs in Inflammatory and Autoimmune Diseases -- Role of Endosomal TLRs in Cancer -- Therapeutic Targeting of Endosomal TLRs -- Agonists of Endosomal TLRs -- Antagonists of Endosomal TLRs -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- SUBJECT INDEX. | |
| 588 | _aDescription based on publisher supplied metadata and other sources. | ||
| 590 | _aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. | ||
| 650 | 0 | _aClinical medicine. | |
| 650 | 0 | _aMedical innovations. | |
| 655 | 4 | _aElectronic books. | |
| 776 | 0 | 8 |
_iPrint version: _aAtta-ur-Rahman _tFrontiers in Clinical Drug Research - Anti-Allergy Agents: Volume 3 _dSharjah : Bentham Science Publishers,c2018 _z9781681083384 |
| 797 | 2 | _aProQuest (Firm) | |
| 830 | 0 | _aFrontiers in Clinical Drug Research - Anti-Allergy Agents Series | |
| 856 | 4 | 0 |
_uhttps://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5491306 _zClick to View |
| 999 |
_c4410 _d4410 |
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