000			05245nam a22004453i 4500
001			EBC5897816
003			MiAaPQ
005			20240724113941.0
006			m o d |
007			cr cnu||||||||
008			240724s2018 xx o ||||0 eng d
020			_a9781910190746 _q(electronic bk.)
020			_z9781910190739
035			_a(MiAaPQ)EBC5897816
035			_a(Au-PeEL)EBL5897816
035			_a(OCoLC)1049975168
040			_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ
050		4	_aQR410.2.E55 .E584 2018
082	0		_a576.6484
100	1		_aJackson, William T.
245	1	0	_aEnteroviruses : _bOmics, Molecular Biology, and Control.
250			_a1st ed.
264		1	_aNorfolk : _bCaister Academic Press, _c2018.
264		4	_c©2018.
300			_a1 online resource (164 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
505	0		_aIntro -- Contents -- Current Books of Interest -- Preface -- 1 Enteroviruses Future -- Introduction -- Curiouser and curiouser -- Viral eradication and control by vaccination -- Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses -- Enteroviruses in 10 years -- 2 Enterovirus Receptors and Entry -- Introduction -- The Enterovirus capsid -- Attachment to a cellular receptor -- Use of multiple receptors -- Uncoating: formation of expanded A-particles -- Uncoating: RNA release -- Where does uncoating occur? -- Introduction to endocytosis -- Other forms of endocytosis -- Post-internalization events -- Concluding thoughts -- 3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses -- Introduction -- Viral proteinase disruption of host machinery -- Use and abuse of host cell functions for viral translation and RNA replication -- Evasion of host antiviral and stress response pathways and mRNA surveillance -- Summary -- 4 The Omics of Rhinoviruses -- The Rhinoviruses -- How RV taxa are defined -- Making an informative alignment -- Prediction of an RV-C capsid -- Statistical prediction of immunogenicity -- Other uses for RV sequences -- 5 Viral Population Dynamics and Sequence Space -- Quasispecies dynamics of Enteroviruses: model RNA viruses -- Mutation rates and RdRp fidelity -- Recombination -- Sequence space and fitness landscapes -- Viral adaptation dynamics: step-wise walks along the landscape -- Intra-population interactions: complementation and interference -- Group contribution of minority variants to phenotype -- The genomics era: challenges and prospects of high-throughput sequencing technologies -- Final conclusions -- 6 Enterovirus Control of Cytoplasmic RNA Granules -- Cytoplasmic RNA granules -- Mechanisms of stress granule assembly.
505	8		_aEnterovirus relationships with stress granules: antagonism rules -- How does G3BP cleavage block stress granule assembly? -- Enterovirus relationships with P-bodies: rapid destruction -- Why Enteroviruses must antagonize RNA granules -- Future directions -- 7 The Autophagic Pathway and Enterovirus Infection -- Autophagy was first identified in Enterovirus infections through electron microscopy -- Basics of autophagy -- The relationship between Enteroviruses and autophagy -- Release of Enteroviruses without lysis -- Enterovirus proteins promote autophagic signalling and degradation -- Triggering of autophagy upon virus entry -- Coxsackievirus regulation of the autophagy pathway -- Enterovirus 71 -- Rhinovirus -- The dual nature of autophagy -- The current model -- 8 The Lipid Blueprints of Replicating Viral Genomes -- Introduction -- Membranes facilitate replication -- Convergence on a common lipid blueprint -- Advantages of enriching for PI4P lipids in replication organelles -- Mechanisms and consequences of viral induction of PI4P lipid production -- Phosphatidylethanolamine -- Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains -- Viral mechanisms of obtaining cholesterol -- Therapeutic potential of targeting lipids and future directions -- Index.
520			_aThis book represents a comprehensive tour of the current most important enterovirus research. The editors, Dr. Jackson and Dr. Coyne, have assembled a group of enteroviral experts who cover topics including viral entry and the hijacking of host functions; the dynamic analysis of ever-evolving virus genomes; the cellular membrane changes promoting virus assembly and release. This volume is a must-read for anyone with an interest in this family of viruses and an important acquisition for all microbiology libraries.
588			_aDescription based on publisher supplied metadata and other sources.
590			_aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
650		0	_aEnteroviruses.
655		4	_aElectronic books.
700	1		_aCoyne, Carolyn B.
776	0	8	_iPrint version: _aJackson, William T. _tEnteroviruses _dNorfolk : Caister Academic Press,c2018 _z9781910190739
797	2		_aProQuest (Firm)
856	4	0	_uhttps://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897816 _zClick to View
999			_c13426 _d13426