Immunodeficient Rodents : A Guide to Their Immunobiology, Husbandry, and Use.

Immunodeficient Rodents -- Copyright -- Preface -- Contents -- 1 Introduction -- IMMUNE SYSTEM FUNCTION -- Host Defense Systems -- The Nature of Adaptive Immunity -- Immunologic Specificity -- Afferent, Central, and Efferent Limbs of the Immune System -- Afferent Limb -- Central Limb -- Efferent Limb -- Immunodeficiency -- EFFECT OF ENVIRONMENTAL FACTORS ON IMMUNE FUNCTION -- Noninfectious Agents -- Infectious Agents -- GENERAL CONSIDERATIONS FOR MAINTAINING IMMUNODEFICIENT RODENTS -- MUTATIONS -- GENE MARKERS AND CHROMOSOME MAPS -- NOMENCLATURE AND SOURCES OF IMMUNODEFICIENT RODENTS -- General Reading -- 2 Hereditary Immunodeficiencies -- MICE WITH SINGLE MUTATIONS -- Bcgr, Bcgs (Resistance and Susceptibility to Mycobacterium bovis) -- Ityr, Itys (Resistance and Susceptibility to Salmonella... -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- bg (Beige) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- db (Diabetes) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- df (Ames Dwarf) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Dh (Dominant Hemimelia) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- dw (Dwarf) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- gl (Grey-Lethal) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- gld (Generalized Lymphoproliferative Disease) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Hc0 (Hemolytic Complement Absent) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- hr (Hairless) -- hrrh (Rhino) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- lh (Lethargic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- lpr (Lymphoproliferation) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Lpsd (Lipopolysaccharide Response, Defective) -- Genetics.

Pathophysiology -- Husbandry -- Reproduction -- Me (Motheaten) -- Mev (Viable Motheaten) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- mi (Microphthalmia) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- nu (Nude) -- nustr (Streaker) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- ob (Obese) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- oc (Osteosclerotic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- op (Osteopetrosis) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- scid (Severe Combined Immunodeficiency) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Tol-1 (Tolerance to Gamma-Globulin) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- vit (Vitiligo) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- W (Dominant Spotting) -- Wv (Viable Dominant Spotting) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- wst (Wasted) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- xid (X-Linked Immune Deficiency) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- Yaa (Y-Linked Autoimmune Accelerator) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- S-Region-Linked Genes Controlling Murine C4 -- Genetics and Pathophysiology -- Husbandry -- Reproduction -- MICE WITH MULTIPLE MUTATIONS -- gld (Generalized Lymphoproliferative Disease) -- xid (X-Linked Immune Deficiency) -- lpr (Lymphoproliferation) -- nu (Nude) -- lpr (Lymphoproliferation) -- xid (X-Linked Immune Deficiency) -- lpr (Lymphoproliferation) -- Yaa (Y-Linked Autoimmune Accelerator) -- nu (Nude) -- bg (Beige) -- nu (Nude) -- xid (X-Linked Immune Deficiency) -- nu (Nude) -- bg (Beige) -- xid (X-Linked Immune Deficiency) -- nu (Nude) -- Dh (Dominant Hemimelia) -- Yaa (Y-Linked Autoimmune Accelerator) -- bg (Beige).

Yaa (Y-Linked Autoimmune Accelerator) -- xid (X-Linked Immune Deficiency) -- INBRED STRAINS OF MICE -- BSVR, BSVS -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- BXSB/Mp Females -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- DBA/2Ha -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- MRL/Mp -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NOD (Non-Obese Diabetic) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NON (Non-Obese Normal) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NZB (New Zealand Black) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- NZB × NZW F1 Hybrids -- Pathophysiology -- Husbandry -- Reproduction -- NZB × SWR F1 or SWR × NZB F1 Hybrids -- Genetics -- Pathophysiology -- PN (Palmerston North) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SAM-P (Senescence Accelerated Mouse) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SJL/J -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- SL/Ni -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- OUTBRED MICE -- SWAN (Swiss Antinuclear) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- RAT MUTANTS -- ia (Incisor Absent) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- op (Osteopetrosis) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- rnu (Rowett Nude) -- rnuN (nznu, New Zealand Nude) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- tl (Toothless) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C4 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- INBRED STRAINS OF RATS -- BB/Wor and Other Sublines -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- LOU/C -- GUINEA PIG MUTANTS -- C2 Deficiency -- Genetics -- Pathophysiology -- Husbandry.

Reproduction -- C3 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C4 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- HAMSTER MUTANTS -- nu (Nude) -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- C6 Deficiency -- Genetics -- Pathophysiology -- Husbandry -- Reproduction -- 3 Induced Immunodeficiencies -- CHEMICAL INDUCERS -- Diethylstilbestrol -- Heavy Metals -- Lead -- Cadmium -- Phenols -- Alkylating Agents -- Glucocorticoids -- INFECTIOUS AGENTS -- NUTRITION -- IONIZING AND ULTRAVIOLET RADIATION -- BIOLOGICAL INDUCERS -- THYMECTOMY -- 4 Maintenance of Rodents Requiring Isolation -- GENERAL CONSIDERATIONS -- SPECIAL FACILITIES AND EQUIPMENT -- Plastic Cages with Filter Covers -- HEPA-Filtered Laminar-Air-Flow Systems -- Germfree Isolators -- Individually Ventilated Cage Racks -- SPECIALIZED HUSBANDRY -- General Considerations -- Environmental Conditions -- Temperature -- Humidity, Ventilation, and Lighting -- Food and Water -- Bedding -- CONTROL OF INFECTION -- Arrival of Stock from Commercial Sources and Transfer of Animals -- Disease Surveillance -- 5 Mating Systems for Mutants -- INBREEDING -- Brother × Sister Inbreeding -- Brother × Sister Inbreeding with Homozygosity -- Brother × Sister Inbreeding with Forced Heterozygosity -- Inbreeding a Balanced Stock -- Transferring a Mutation to an Inbred Background -- Backcross Matings -- Cross-Intercross Matings Using Homozygotes -- Cross-Intercross Matings Using Heterozygotes -- Cross-Intercross Matings Using Ovarian Transplantation -- PROPAGATION WITHOUT INBREEDING -- Transferring a Mutation to a Hybrid Background -- Backcross Matings -- Cross-Intercross Matings -- Cross-Intercross Matings Using Ovarian Transplantation -- 6 Genetic Mechanisms Governing Resistance or Susceptibility to Infectious Diseases -- References -- Appendix.

Glossary -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.