How the Immune System Works.

Intro -- Dedication -- Title page -- Copyright -- Acknowledgments -- How to Use This Book -- LECTURE 1 An Overview -- INTRODUCTION -- PHYSICAL BARRIERS -- THE INNATE IMMUNE SYSTEM -- THE ADAPTIVE IMMUNE SYSTEM -- A COMPARISON OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS -- THE INNATE SYSTEM RULES! -- EPILOGUE -- LECTURE 2 The Innate Immune System -- INTRODUCTION -- THE COMPLEMENT SYSTEM -- THE PROFESSIONAL PHAGOCYTES -- HOW IMMUNE SYSTEM SENTINELS RECOGNIZE INVADERS -- HOW THE INNATE IMMUNE SYSTEM DEALS WITH VIRUSES -- THE INNATE IMMUNE SYSTEM - A COOPERATIVE EFFORT -- A PROPORTIONAL RESPONSE -- SUMMARY FIGURE -- LECTURE 3 B Cells and Antibodies -- INTRODUCTION -- THE B CELL RECEPTOR -- HOW THE BCR SIGNALS -- HOW B CELLS ARE ACTIVATED -- CLASS SWITCHING -- ANTIBODY CLASSES AND THEIR FUNCTIONS -- SOMATIC HYPERMUTATION -- B CELLS MAKE A CAREER CHOICE -- SUMMARY FIGURE -- LECTURE 4 The Magic of Antigen Presentation -- INTRODUCTION -- CLASS I MHC MOLECULES -- CLASS II MHC MOLECULES -- ANTIGEN PRESENTATION BY CLASS I MHC MOLECULES -- ANTIGEN PRESENTATION BY CLASS II MHC MOLECULES -- ANTIGEN PRESENTING CELLS -- THE LOGIC OF CLASS I MHC PRESENTATION -- THE LOGIC OF CLASS II MHC PRESENTATION -- CROSS-PRESENTATION -- NON-CLASSICAL MHC MOLECULES AND LIPID PRESENTATION -- MHC PROTEINS AND ORGAN TRANSPLANTS -- SUMMARY FIGURE -- LECTURE 5 T Cell Activation -- INTRODUCTION -- T CELL RECEPTORS -- HOW A T CELL'S RECEPTORS SIGNAL -- CD4 AND CD8 CO-RECEPTORS -- CO-STIMULATION -- A TIME-LAPSE PHOTO OF HELPER T CELL ACTIVATION -- HOW KILLER T CELLS ARE ACTIVATED -- FAIL-SAFE ACTIVATION -- LECTURE 6 T Cells at Work -- INTRODUCTION -- HELPER T CELLS AS CYTOKINE FACTORIES -- THE DENDRITIC CELL AS "COACH" OF THE IMMUNE SYSTEM TEAM -- Th1 HELPER T CELLS -- Th2 HELPER T CELLS -- Th17 HELPER T CELLS -- Th0 HELPER T CELLS -- LOCKING IN THE HELPER T CELL PROFILE.

DELAYED-TYPE HYPERSENSITIVITY -- HOW CTLs KILL -- SUMMARY FIGURE -- LECTURE 7 Secondary Lymphoid Organs and Lymphocyte Trafficking -- INTRODUCTION -- LYMPHOID FOLLICLES -- HIGH ENDOTHELIAL VENULES -- LYMPH NODES -- PEYER'S PATCHES -- THE SPLEEN -- THE LOGIC OF SECONDARY LYMPHOID ORGANS -- LYMPHOCYTE TRAFFICKING -- WHY MOTHERS KISS THEIR BABIES -- LECTURE 8 Restraining the Immune System -- INTRODUCTION -- ATTENUATING THE IMMUNE RESPONSE -- DEACTIVATING THE SYSTEM -- LIFE IS SHORT -- EXHAUSTION -- LECTURE 9 Self Tolerance and MHC Restriction -- INTRODUCTION -- THE THYMUS -- MHC RESTRICTION -- THE LOGIC OF MHC RESTRICTION -- THYMIC TESTING FOR TOLERANCE OF SELF -- GRADUATION -- THE RIDDLE OF MHC RESTRICTION AND TOLERANCE INDUCTION -- TOLERANCE BY IGNORANCE -- TOLERANCE INDUCTION IN SECONDARY LYMPHOID ORGANS -- PERIPHERAL TOLERANCE INDUCTION -- TOLERANCE DUE TO ACTIVATION-INDUCED CELL DEATH -- B CELL TOLERANCE -- MAINTENANCE OF B CELL TOLERANCE IN GERMINAL CENTERS -- POSITIVE SELECTION OF NATURAL KILLER CELLS -- LECTURE 10 Immunological Memory -- INTRODUCTION -- INNATE MEMORY -- ADAPTIVE MEMORY -- PROPERTIES OF ADAPTIVE MEMORY CELLS -- COMPARING B AND T CELL MEMORIES -- INNATE VERSUS ADAPTIVE MEMORY -- LECTURE 11 The Intestinal Immune System -- INTRODUCTION -- INTESTINAL ARCHITECTURE -- HOW THE INTESTINAL IMMUNE SYSTEM DEALS WITH INVADERS -- HOW DOES THE INTESTINAL IMMUNE SYSTEM TELL FRIEND FROM FOE? -- LECTURE 12 Vaccines -- INTRODUCTION -- GENERATING MEMORY HELPER T AND B CELLS -- GENERATING MEMORY KILLER T CELLS -- STRATEGIES FOR VACCINE DEVELOPMENT -- VACCINE ADJUVANTS -- WILL THERE BE AN AIDS VACCINE? -- LECTURE 13 The Immune System Gone Wrong -- INTRODUCTION -- PATHOLOGICAL CONDITIONS CAUSED BY A NORMAL IMMUNE RESPONSE -- DISEASES CAUSED BY DEFECTS IN IMMUNE REGULATION -- AUTOIMMUNE DISEASE -- LECTURE 14 Immunodeficiency -- INTRODUCTION.

GENETIC DEFECTS LEADING TO IMMUNODEFICIENCY -- AIDS -- LECTURE 15 Cancer and the Immune System -- INTRODUCTION -- CANCER IS A CONTROL SYSTEM PROBLEM -- CLASSIFICATION OF CANCER CELLS -- IMMUNE SURVEILLANCE AGAINST CANCER -- IMMUNE SURVEILLANCE BY MACROPHAGES AND NK CELLS -- VACCINATION TO PREVENT VIRUS-ASSOCIATED CANCER -- Glossary -- List of Acronyms and Abbreviations -- Index -- EULA.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.