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Molecular Mechanisms Involved in the Pathogenesis of Huntington's Disease.

By: Contributor(s): Material type: TextTextSeries: Neurodegenerative Diseases - Laboratory and Clinical ResearchPublisher: Hauppauge : Nova Science Publishers, Incorporated, 2010Copyright date: ©2010Edition: 1st edDescription: 1 online resource (66 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781617613524
Subject(s): Genre/Form: Additional physical formats: Print version:: Molecular Mechanisms Involved in the Pathogenesis of Huntington's DiseaseDDC classification:
  • 616.8/51
LOC classification:
  • RC394.H85 -- P44 2010eb
Online resources:
Contents:
Intro -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Huntington's Disease -- 1.1. Introduction: Unstable Expanding -- Repeats as a Novel Cause of Disease -- 1.2. Common Features of Diseases due to Unstable Expanding Repeats -- 1.3. Clinical and Genetic Aspects of HD -- 1.4. Epidemiology of HD -- 1.5. Clinical Correlates in HD -- A. Chorea and Motor Impairment -- B. Age at Onset -- C. Rate of Disease Progression -- D. Neuropsychology -- 1. Cognitive Function in HD -- 2. CAG Relationship to Cognition -- E. Clinical Correlates of Mitochondrial Function in HD Muscle -- 1.6. Isolation of the HD Mutation -- 1.7. The HD Trinucleotide Repeat Mutation -- 1.8. Neuropathologic Studies in HD -- Molecular Pathogenesis of Huntington'S Disease -- 2.1. HD Gene and Gene Product -- 2.2. Correlation between Neuropathology and Pathogenesis in HD -- 2.3. Models for the Pathogenesis of HD -- 2.4. Nuclear Effect of Mutant Huntingtin -- 2.5. Cytoplasmic Effect of Mutant Huntingtin -- A. Axonal Transport in HD -- B. Mitochondrial/Bioenergetic Dysfunction and HD -- Conclusion -- References -- Index.
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Intro -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Huntington's Disease -- 1.1. Introduction: Unstable Expanding -- Repeats as a Novel Cause of Disease -- 1.2. Common Features of Diseases due to Unstable Expanding Repeats -- 1.3. Clinical and Genetic Aspects of HD -- 1.4. Epidemiology of HD -- 1.5. Clinical Correlates in HD -- A. Chorea and Motor Impairment -- B. Age at Onset -- C. Rate of Disease Progression -- D. Neuropsychology -- 1. Cognitive Function in HD -- 2. CAG Relationship to Cognition -- E. Clinical Correlates of Mitochondrial Function in HD Muscle -- 1.6. Isolation of the HD Mutation -- 1.7. The HD Trinucleotide Repeat Mutation -- 1.8. Neuropathologic Studies in HD -- Molecular Pathogenesis of Huntington'S Disease -- 2.1. HD Gene and Gene Product -- 2.2. Correlation between Neuropathology and Pathogenesis in HD -- 2.3. Models for the Pathogenesis of HD -- 2.4. Nuclear Effect of Mutant Huntingtin -- 2.5. Cytoplasmic Effect of Mutant Huntingtin -- A. Axonal Transport in HD -- B. Mitochondrial/Bioenergetic Dysfunction and HD -- Conclusion -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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