Novel Strategies and Approaches in Hypertension Therapy.

Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- Dedication -- List of Contributors -- Environmental Aspects of Hypertension -- Umesh Jayarajah1,3 and Suranjith L. Seneviratne2,3,* -- INTRODUCTION -- COLD AMBIENT TEMPERATURE RELATED HYPERTENSION -- Pathophysiology of Cold Ambient Temperature Related Hypertension -- NOISE EXPOSURE-RELATED HYPERTENSION -- Industrial Noise Exposure and Hypertension -- Road Traffic Noise Exposure and Hypertension -- Aircraft Noise Exposure and Hypertension -- Pathophysiology of Noise Exposure Related Hypertension -- AIR POLLUTION-RELATED HYPERTENSION -- Short-Term Effects of Air Pollution -- Long-term Effects of Air Pollution -- Pathophysiology of Air Pollution-Related Hypertension -- Clinical Relevance of Air Pollution-Related Hypertension -- High Altitude Related Hypertension -- Pathophysiology of High Altitude Related Hypertension -- Clinical Implications of High Altitude Related Hypertension -- Other Environmental Factors-Related Hypertension -- OVERALL CLINICAL IMPLICATIONS AND PREVENTIVE MEASURES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Occupational Aspects of Hypertension -- Umesh Jayarajah1,3 and Suranjith L. Seneviratne2,3,* -- INTRODUCTION -- OBJECTIVES -- EFFECT OF JOB STRAIN ON HYPERTENSION AND ITS ASSOCIATED FACTORS -- HYPERTENSION AMONG DIFFERENT OCCUPATIONS -- Hypertension in Healthcare Workers -- Hypertension in School Teachers and University Staff -- Hypertension in White Collar Workers -- Hypertension in Blue Collar Workers -- Hypertension in Heavy Vehicle Drivers -- Hypertension in Fire Fighters, Police Officers, Prison Guards, and Other Emergency Responders -- Hypertension Among other Occupational Categories -- PREVENTIVE STRATEGIES AND IMPLICATIONS IN MANAGEMENT -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST.

ACKNOWLEDGEMENT -- REFERENCES -- Antihypertensive Drug Interactions -- Cigdem Usul Afsar1 and Sibel Ozyazgan2,* -- INTRODUCTION -- Pharmacokinetic Interactions -- Pharmacodynamic Interactions -- Drug Interactions of Antihypertensive Drugs, Classified According to Drug Class -- A. Alpha Blockers (Table 2) -- B. Beta Blockers (Table 3) -- C. Calcium Channel Blockers (Table 4) -- D. Angiotensin Converting Enzyme İnhibitors (ACEI) and Angiotensin II (AT-II) Receptor Antagonists (Table 5) -- E. Diuretics -- F. Renin Inhibitors -- G. Centrally Acting Antihypertensives -- CONCLUSION/FUTURE PERSPECTIVES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Pulmonary Hypertension -- Pelin Uysal1 and Hafize Uzun2,* -- INTRODUCTION -- Classification -- Epidemiology -- Physiopathology -- Diagnosis and Algorithm -- Treatment and Prognosis -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Hypertension in Thyroid Disorders -- Lebriz Uslu-Beşli1 and Pınar Atukeren2,* -- THYROID HORMONE SYNTHESIS AND FUNCTIONS -- THYROID DISEASES RELATED WITH HYPERTENSION -- Hyperthyroidism -- Causes of Hyperthyroidism -- Hypothyroidism -- Causes of Hypothyroidism -- PATHOGENESIS OF THYROID DISEASE RELATED HYPERTENSION -- Effects on Vascular System and Blood Volume -- Effects on Cardiac Function -- Renal Dysfunction -- Effects on Blood Pressure Regulation -- Renin-Angiotensin-Aldosterone System -- Natriuretic Peptides -- Antidiuretic Hormone (Vasopressin) -- Catecholamines -- Adrenomedullin -- Erythropoietin -- DIAGNOSIS OF THYROID DISORDERS -- TREATMENT OF THYROID DISEASE RELATED HYPERTENSION -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Arterial Hypertension in Type 2 Diabetes: Pathogenesis and Treatment.

Mustafa Kanat1,*, Abdulhalim Senyigit2 and Muhammad A Abdul-Ghani3 -- INTRODUCTION -- Diabetes, Hypertension and their Coexistence -- Diabetes and Hypertension: What do They Share in Common? -- Increased Renal Sodium Retention -- Sympathetic Nervous System (SNS) Overactivity -- Nitric-Oxide Pathway, MAPK Overactivity, and Enhanced Growth Factors -- Sodium-Glucose Cotransporter 2 (SGLT2) Overactivity -- Altered Cellular Ion Pumps Activity and Increased pH -- Blood Pressure Control in Patients with Diabetes -- Blood Pressure Goal in Patients with T2DM -- What did We Learn from Randomized Clinical Trials? -- Treatment of Hypertension in Diabetic Patients -- Lifesytle Intervention -- Pharmacological Therapy -- Albuminuria as a Guide for the Selection of Antihypertensive Drugs -- Treatment of Hypertension with Chronotherapy -- Treatment of Resistant Hypertension -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Hypertension in Pregnancy-Preeclampsia -- Karolin Yanar and Pınar Atukeren* -- INTRODUCTION -- Chronic Hypertension -- Gestational Hypertension -- De Novo or Superimposed on Chronic Hypertension or White Coat Hypertension -- Preeclampsia-Eclampsia -- Risk Factors of Preeclampsia -- Inflammation-Related Gene Polymorphisms -- Lipoprotein Metabolism-Related Gene Polymorphism -- Other Maternal Gene Polymorphism -- Pathophysiologic and Pathobiochemical Mechanisms of Preeclampsia -- Altered Vasoactive Substances -- Endoglin -- Endoplasmic Reticulum Stress -- Outcomes of Preeclampsia on Fetus -- Outcomes of Preeclampsia on Mother -- Screening Methods for Early Detection of Preeclampsia -- Prevention of Preeclampsia with Endogen Factors -- Prevention of Preeclampsia with Environmental Factors -- Management of Hypertensive Disorders with Therapeutics -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION.

CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Endocrinal Hypertension and Hyperaldosteronism: Biochemical and Genetic Aspects of Adrenal Dependent Endocrinal Hypertension -- Sinem Durmus and Hafize Uzun* -- INTRODUCTION -- Pheochromocytoma and Sympathetic Paraganglioma -- Hyperdeoxycorticosteronism -- Cushing Syndrome -- Apparent Mineralocorticoid Excess/11ß-Hydroxysteroid Dehydrogenase Deficiency -- Primary Aldosteronism -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- The Use of Calcium Channel Blockers and Risk of the Breast Cancer -- Berrin Papila Kundaktepe1 and Hafize Uzun2,* -- HYPERTENSION -- Prevalence -- Treatment -- TIMELINE OF ANTIHYPERTENSIVE TREATMENT -- CALCIUM CHANNEL BLOCKERS -- Definition -- Mechanism of Action -- Classification -- Usage -- Side Effects -- BREAST CANCER -- Overview -- Epidemiology -- Survival -- Risk Factors -- Diagnosis -- Types -- Treatment Options -- HYPOTHESIS ABOUT CCBS AND CANCER -- STUDIES AND CONTROVERSIAL RESULTS -- DISCUSSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Neurogenic Hypertension -- Gonul Simsek* and Aykut Oruc -- CNS CARDIOVASCULAR PATHWAYS -- AUTONOMIC OUTPUTS AND BULBOSPINAL CENTERS -- REFLEX MECHANISMS MAINTAINING BLOOD PRESSURE REGULATION -- Circulatory Reflex Initiated By The Baroreceptors -- Cardiopulmonary Baroreceptors (Low-Pressure Receptors) -- Control of Arterial Pressure by Chemoreceptors -- Pulmonary Stretch Receptors -- PATOPHYSIOLOGIC MECHANISMS OF NEUROGENIC HYPERTENSION -- Proposed Causes of İncreased Sympathetic Tone in Essential Hypertension -- Impaired Baroreceptor Reflexes -- Carotid Body Overactivity -- Augmented Central Respiratory-Sympathetic Coupling -- Vascular Compression of the Medulla -- Aging -- Psychological Factors -- Nitric Oxide.

Reactive Oxygen Species -- Angotensin II -- Dietary Salt and Vasopressin -- Obesity -- Proinflammatory Cytokines -- Genetic Factors -- NEUROPLASTICITY IN HYPERTENSION -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Link Between Obesity and Hypertension Through Molecular Mechanisms -- Dildar Konukoglu* -- INTRODUCTION -- Classification of Obesity -- Pathogenesis of Obesity -- Dysregulation of Appetite Control -- Obesity and Adipokines -- Obesity and Insulin Resistance -- Obesity, Oxidative Stress, and Inflammation -- Obesity and Endothelial Dysfunction -- Obesity and Genetics -- Possible Molecular Link Between Obesity and Hypertension -- Increased Activity of RAS in Obesity is Related to Hypertension -- Leptin Resistance in Obesity and Effects on Blood Pressure -- Insulin Resistance-Linked Obesity Triggers Hypertension -- Obesity Triggers Hypertension via Endothelial Dysfunction -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Significance of Vitamin D Status in Elderly Patients with Systemic Arterial Hypertension -- Bahadir Simsek and Ufuk Çakatay* -- CARDIOVASCULAR DISEASE AND VITAMIN D -- Hypertension and Vitamin D -- Vitamin D Metabolism and Signaling Pathways -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Emerging and Routine Biomarkers in Hyper-tension, Current Aspects and Future Directions -- Mustafa Erinç Sitar1 and Pınar Atukeren2,* -- INTRODUCTION -- DIAGNOSIS OF HYPERTENSION -- General Screening Tests -- Definitive Diagnosis and Secondary Hypertension -- Treatment and Follow-up Phase -- EMERGING BIOMARKERS -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Medical Nutrition in Hypertension.

M. Emel Alphan1 and Pınar Atukeren2,*.

Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end organ damage including left-ventricular hypertrophy and congestive heart failure, which in-turn increases the risk of cardiovascular morbidity and mortality. While studies of hypertension have been performed worldwide in a variety of epidemiological settings such as diabetes, renal function, obesity and thyroid disorders, there is a need to identify appropriate treatment strategies Novel Strategies and Approaches in Hypertension introduces the reader to different aspects of hypertension treatment (environmental and occupational factors and different clinical settings that can trigger the disease). The book also covers special topics related to the use of new diagnostic biomarkers for hypertension patients, as well as endocrine and nutrition focused approaches to treat the condition. This reference book will be useful for medical professionals involved in the management and care of patients affected with hypertension.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.