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The Application of Toxicogenomics for (Drinking) Water Quality Assessment.

By: Contributor(s): Material type: TextTextSeries: KWR Watercycle Research Institute SeriesPublisher: London : IWA Publishing, 2014Copyright date: ©2014Edition: 1st edDescription: 1 online resource (36 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781780406671
Subject(s): Genre/Form: Additional physical formats: Print version:: The Application of Toxicogenomics for (Drinking) Water Quality AssessmentDDC classification:
  • 628.16
LOC classification:
  • TD367 -- .S3 2014eb
Online resources:
Contents:
Cover -- Copyright -- Colofon -- Summary -- Contents -- 1. Introduction -- 2. Technical background -- 2.1 Biology -- 2.2 Toxicology -- 2.3 Genomics -- 2.4 Transcriptomics with DNA microarrays -- 2.5 Sensitivity -- 2.6 Analysis time -- 2.7 Responsiveness -- 2.8 Specificity -- 2.9 Cross species extrapolation -- 3. Toxicogenomics -- 4. Application of toxicogenomics -- 4.1 No Observable Transcriptional Effect Level (NOTEL) concept -- 4.2 Mode of action (MOA) approaches -- 4.3 Environmental monitoring -- 4.4 Risk assessment -- 4.5 Investigation of biological processes controlled by gene networks -- 5. Challenges for toxicogenomics -- 5.1 Model system complexity -- 5.2 Confounding factors -- 5.3 Mixtures -- 5.4 Limited sequence data -- 5.5 Bioinformatics -- 5.6 Costs -- 6. Research needs for regulatory implementation -- 7. Discussion on toxicogenomics for water quality monitoring -- 7.1 Mechanisms of toxicity and predictive toxicology -- 7.2 Environmental monitoring -- 7.3 NOTEL -- 7.4 Genomics as a tool for monitoring in relation to in vitro bioassays -- 7.5 Conclusions and outlook -- 8. Acknowledgements -- 9. References.
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Cover -- Copyright -- Colofon -- Summary -- Contents -- 1. Introduction -- 2. Technical background -- 2.1 Biology -- 2.2 Toxicology -- 2.3 Genomics -- 2.4 Transcriptomics with DNA microarrays -- 2.5 Sensitivity -- 2.6 Analysis time -- 2.7 Responsiveness -- 2.8 Specificity -- 2.9 Cross species extrapolation -- 3. Toxicogenomics -- 4. Application of toxicogenomics -- 4.1 No Observable Transcriptional Effect Level (NOTEL) concept -- 4.2 Mode of action (MOA) approaches -- 4.3 Environmental monitoring -- 4.4 Risk assessment -- 4.5 Investigation of biological processes controlled by gene networks -- 5. Challenges for toxicogenomics -- 5.1 Model system complexity -- 5.2 Confounding factors -- 5.3 Mixtures -- 5.4 Limited sequence data -- 5.5 Bioinformatics -- 5.6 Costs -- 6. Research needs for regulatory implementation -- 7. Discussion on toxicogenomics for water quality monitoring -- 7.1 Mechanisms of toxicity and predictive toxicology -- 7.2 Environmental monitoring -- 7.3 NOTEL -- 7.4 Genomics as a tool for monitoring in relation to in vitro bioassays -- 7.5 Conclusions and outlook -- 8. Acknowledgements -- 9. References.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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