Knobil and Neill's Physiology of Reproduction.

e9780123971753v1 -- Front Cover -- KNOBIL AND NEILL'S PHYSIOLOGY OF REPRODUCTION -- Copyright -- Illustration Credits -- Contents -- Contributors -- Introduction -- Preface -- Foreword* by Roy O. Greep -- Foreword by M. Susan Smith -- VOLUME 1 -- SECTION 1 - GAMETES, FERTILIZATIONAND EMBRYOGENESIS -- Chapter 1 - Mammalian Meiosis -- INTRODUCTION -- INITIATION OF MEIOSIS IN MAMMALS -- PROPHASE I -- CHROMOSOME SEGREGATION AT METAPHASE I (MI) AND MEIOTIC PROGRESSION -- DISORDERS OF MEIOSIS -- CONCLUSION -- Acknowledgments -- References -- Chapter 2 - The Mammalian Oocyte -- INTRODUCTION -- CELL BIOLOGY OF THE OOCYTE -- THE GROWTH PHASE OF OOGENESIS -- MATURATION PHASE OF OOGENESIS: THE FINAL ACT -- CLINICAL PARAMETERS OF OOCYTE BIOLOGY -- CONCLUSION -- Acknowledgments -- References -- Chapter 3 - The Spermatozoon -- INTRODUCTION -- THE SPERM PLASMA MEMBRANE -- THE SPERM HEAD -- THE FLAGELLUM -- CONCLUSION -- References -- Chapter 4 - Fertilization in Mammals -- INTRODUCTION -- SPERM CAPACITATION -- SPERM-EGG INTERACTION -- SPERM-EGG PLASMA MEMBRANE INTERACTIONS -- EVENTS FOLLOWING SPERM-EGG MEMBRANE FUSION -- SIGNALING PATHWAYS RESPONSIBLE FOR THE EVENTS OF EGG ACTIVATION -- CONCLUSION -- ADDENDUM -- Acknowledgments -- References -- Chapter 5 - Gamete and Zygote Transport -- INTRODUCTION -- SPERM TRANSPORT -- OOCYTE AND EMBRYO TRANSPORT IN THE OVIDUCT -- CONCLUSION -- References -- Chapter 6 - Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification -- INTRODUCTION -- EMBRYOGENESIS -- EMBRYONIC STEM CELLS -- GERM LINE DEVELOPMENT -- GONADAL STEM CELLS -- GENERATION OF GAMETES FROM PLURIPOTENT STEM CELLS -- CONCLUSION -- Acknowledgment -- References -- Chapter 7 - Sex Determination and Differentiation -- INTRODUCTION -- CHROMOSOMAL SEX -- GONADAL SEX -- PHENOTYPIC SEX -- CONCLUSION -- References.

SECTION 2 - GONADAL STEROIDS, PITUITARY AND HYPOTHALAMUS -- Chapter 8 - Human Steroid Biosynthesis -- INTRODUCTION -- GENERAL CONCEPTS -- THE CONVERSION OF CHOLESTEROL TO PREGNENOLONE AND MITOCHONDRIAL STEROID METABOLISM -- STEROID HYDROXYLATION AND THE MICROSOMAL P450 ENZYMES -- HSDS, THE TERMINAL STEPS, AND PERIPHERAL METABOLISM -- STEROID SULFONATION -- STEROID DEGRADATION AND EXCRETION -- PATHWAYS -- COMPARISON WITH OTHER SPECIES -- CONCLUSION -- References -- Chapter 9 - Gonadal Steroid Action -- INTRODUCTION -- TRANSCRIPTIONAL ACTIONS OF GONADAL STEROIDS -- NONTRANSCRIPTIONAL EFFECTORS OF GONADAL STEROIDS -- STEROID SIGNALING VIA MEMBRANE RECEPTORS -- COREGULATORS AND GONADAL STEROID PHYSIOLOGY -- INFORMATIC APPROACHES AND TRANSCRIPTIONAL REGULATION BY GONADAL STEROIDS -- CONCLUSION -- References -- Chapter 10 - Gonadotropes and Gonadotropin-Releasing Hormone Signaling -- INTRODUCTION -- GONADOTROPES -- PITUITARY ACTIONS AND MECHANISMS OF ACTION OF GNRH -- AUTOCRINE AND PARACRINE REGULATION OF GONADOTROPES -- CONCLUSION -- References -- Chapter 11 - Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network -- INTRODUCTION -- THE GNRH NEURON -- COMPONENTS OF THE GNRH NEURONAL NETWORK -- SYNCHRONIZATION AND PULSATILITY -- HETEROGENEITY WITHIN THE GNRH NEURONAL PHENOTYPE -- ESTROUS CYCLE PLASTICITY -- CONCLUSION -- References -- Chapter 12 - Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin -- INTRODUCTION -- THE PROLACTIN RECEPTOR AND SIGNAL TRANSDUCTION -- NEUROENDOCRINE CONTROL OF PROLACTIN SECRETION -- LACTOTROPH FUNCTION -- PATTERNS OF PROLACTIN SECRETION -- REPRODUCTIVE FUNCTIONS OF PROLACTIN -- PROLACTIN-INDUCED ADAPTIVE RESPONSES CONTRIBUTING TO SUCCESSFUL REPRODUCTION -- REPRODUCTIVE ACTIONS OF PROLACTIN IN THE MALE -- PROLACTIN AND REPRODUCTIVE DISORDERS -- CONCLUSION.

References -- Chapter 13 - Central Nervous System Control of Oxytocin Secretion during Lactation -- INTRODUCTION -- MILK EJECTION IN RESPONSE TO SUCKLING IS AN ATYPICAL NEURONAL REFLEX -- THE BEHAVIOR OF OT NEURONS DURING MILK EJECTION-THE RAT MODEL -- THE AFFERENT PATHWAY MEDIATING MILK EJECTION -- NEUROTRANSMITTERS/NEUROMODULATORS MEDIATING THE MILK EJECTION REFLEX -- ELECTROPHYSIOLOGICAL PROPERTIES OF OT NEURONS AND THEIR PLASTICITY DURING LACTATION -- SYNAPTIC PLASTICITY DURING LACTATION -- A MODEL FOR MILK EJECTION -- CONCLUSION -- Acknowledgments -- References -- SECTION 3 - MALE REPRODUCTIVE SYSTEM -- Chapter 14 - Testicular Development -- INTRODUCTION -- ANATOMICAL, HISTOLOGICAL, AND MORPHOMETRIC DEVELOPMENT -- CONTROL OF TESTIS DEVELOPMENT -- GERM CELLS -- TESTICULAR DEVELOPMENT AND ADULT HEALTH -- CONCLUSION -- References -- Chapter 15 - Spermatogonial Stem Cells and Spermatogenesis -- INTRODUCTION -- SPERMATOGONIAL STEM CELLS AND SPERMATOGENIC LINEAGE DEVELOPMENT -- EXPERIMENTAL TOOLS FOR STUDYING SPERMATOGONIAL STEM CELLS -- THE SPERMATOGONIAL STEM CELL NICHE -- MOLECULAR MECHANISMS GOVERNING SSC DEVELOPMENTAL FATE -- SPERMATOGONIAL STEM CELL AGING -- TRANSGENESIS -- REGENERATIVE POTENTIAL OF SPERMATOGONIAL STEM CELLS AND TRANSLATION TO THE CLINIC -- CONCLUSION -- Acknowledgments -- References -- Chapter 16 - Hormone Signaling in the Testis -- INTRODUCTION -- LUTEINIZING HORMONE -- TESTOSTERONE -- FOLLICLE-STIMULATING HORMONE -- THYROID HORMONE -- ESTROGEN -- ACTIVIN AND INHIBIN -- OTHER HORMONES -- CONCLUSION -- References -- Chapter 17 - The Epididymis -- INTRODUCTION -- DEVELOPMENT OF THE EPIDIDYMIS -- STRUCTURAL ORGANIZATION OF THE EPIDIDYMIS -- FUNCTIONS TAKING PLACE IN THE LUMINAL COMPARTMENT -- REGULATION OF EPIDIDYMAL FUNCTIONS -- MAJOR PROTEIN FAMILIES IN THE EPIDIDYMIS AND THEIR REGULATION -- AGING.

THE EPIDIDYMIS AS TARGET FOR XENOBIOTICS -- CONCLUSION -- Acknowledgments -- References -- Chapter 18 - Accessory Sex Glands in the Male -- INTRODUCTION -- ANATOMY AND HISTOLOGY -- EMBRYOLOGY AND DEVELOPMENT -- FUNCTION OF SEX ACCESSORY TISSUES -- REGULATION OF THE ADULT PROSTATE -- DISEASES OF THE PROSTATE GLAND -- CONCLUSION -- References -- Chapter 19 - The Immunophysiology of Male Reproduction -- INTRODUCTION -- STRUCTURE AND FUNCTION OF THE MALE REPRODUCTIVE TRACT RELEVANT TO IMMUNOPHYSIOLOGY -- THE IMMUNE SYSTEM AND ITS ENDOCRINE CONTROL -- IMMUNE CELLS OF THE MALE REPRODUCTIVE TRACT -- IMMUNOLOGICAL AND INFLAMMATORY MEDIATORS IN THE TESTIS -- EFFECTS OF IMMUNE CELLS AND INFLAMMATION ON MALE REPRODUCTION -- AUTOIMMUNITY IN THE MALE REPRODUCTIVE TRACT -- IMMUNE PRIVILEGE IN THE MALE REPRODUCTIVE TRACT -- INNATE IMMUNITY IN THE MALE REPRODUCTIVE TRACT: THE RESPONSE TO INFECTIONS AND TUMORS -- IMPLICATIONS, APPLICATIONS, AND THE NEXT 10YEARS -- CONCLUSION -- References -- SECTION 4 - FEMALE REPRODUCTIVE SYSTEM -- Chapter 20 - Gonadotropin Signaling in the Ovary -- INTRODUCTION -- FSH SIGNALS PROMOTE FOLLICULAR MATURATION -- FSH SIGNALING PATHWAYS THAT STIMULATE GRANULOSA CELL DIFFERENTIATION AND PROLIFERATION: CAMP AND PKA-DEPENDENT SIGNALING -- CROSS TALK AMONG FSH-REGULATED SIGNALING PATHWAYS AND TRANSCRIPTIONAL ACTIVATORS TO REGULATE GENE EXPRESSION DURING GRANULOSA CE... -- LH SIGNALS THAT REGULATE THECA CELL FUNCTIONS -- THE LH SURGE PROMOTES OOCYTE MATURATION, OVULATION, AND CORPUS LUTEUM FORMATION -- MECHANISMS BY WHICH LH STIMULATES OOCYTE MATURATION, OVULATION, AND LUTEINIZATION -- MOLECULAR BASIS FOR THE DIFFERENTIAL REGULATION OF TARGET GENE EXPRESSION BY FSH IN PREANTRAL AND LH IN PREOVULATORY GRANULOSA C... -- CONCLUSION -- Acknowledgments -- References -- Chapter 21 - Follicular Development: Mouse, Sheep, and Human Models.

INTRODUCTION -- MORPHOLOGY OF FOLLICULOGENESIS -- PRIMORDIAL FOLLICLE FORMATION -- THE PRIMORDIAL TO PRIMARY FOLLICLE TRANSITION -- REGULATION OF FOLLICULOGENESIS BY TGFΒ FAMILY SIGNALING IN THE OVARY -- TRANSCRIPTION FACTORS IN PREANTRAL-STAGE FOLLICULOGENESIS -- ANTRAL FOLLICLE DEVELOPMENT -- METABOLIC INFLUENCES ON FOLLICLE DEVELOPMENT -- CONCLUSION -- Acknowledgments -- References -- Chapter 22 - Ovulation -- INTRODUCTION -- OVULATION: A PERFORMANCE PLAYED BY MANY ACTORS -- SETTING THE STAGE: GRANULOSA CELL FUNCTIONS IN PREOVULATORY FOLLICLES -- ON-STAGE ACT I: LINKING THE LH RECEPTOR TO OTHER SIGNALING PATHWAYS IN GRANULOSA CELLS -- ON-STAGE ACT II: SIGNAL CONNECTIONS BETWEEN GRANULOSA CELLS AND THE CUMULUS CELL-OOCYTE COMPLEX DURING OVULATION -- ON-STAGE ACT III: THE OOCYTE REIGNS AT CENTER STAGE -- ON-STAGE ACT IV: KEY TRANSCRIPTION FACTORS THAT IMPACT OVULATION -- ON STAGE ACT V: KEY PROTEASES IN OVULATION -- ON STAGE ACT VI: CUMULUS CELLS HAVE IMMUNE-LIKE FUNCTIONS AND A DISTINCT FATE -- OFF-STAGE AND BEHIND THE SCENES: FOLLICLE ATRESIA AND GRANULOSA CELL APOPTOSIS -- TRANSLATIONAL CLINICAL CONSIDERATIONS -- CONCLUSION -- References -- Chapter 23 - Structure, Function, and Regulation of the Corpus Luteum -- INTRODUCTION -- CLASSIFICATION OF TYPES OF CORPORA LUTEA -- LUTEINIZATION -- LUTEOLYSIS -- REGULATION OF LUTEAL STRUCTURE AND FUNCTION -- LUTEAL CELL TYPES AND THEIR REGULATION -- CONCLUSION -- Acknowledgments -- References -- Chapter 24 - Human Oviduct and Endometrium: Changes over the Menstrual Cycle -- INTRODUCTION -- ANATOMY, EMBRYOLOGY, AND HISTOLOGY: AN OVERVIEW -- OVIDUCT -- ENDOMETRIUM -- CONCLUSION -- References -- Chapter 25 - Steroid Receptors in the Uterus and Ovary -- INTRODUCTION -- THE STEROID RECEPTORS -- SEX STEROID RECEPTORS IN UTERINE FUNCTION -- SEX STEROID RECEPTORS AND OVARIAN FUNCTION -- SUMMARY -- CONCLUSION.

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