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Microbial Efflux Pumps : Current Research.

By: Contributor(s): Material type: TextTextPublisher: Norfolk : Caister Academic Press, 2013Copyright date: ©2013Edition: 1st edDescription: 1 online resource (259 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781908230867
Subject(s): Genre/Form: Additional physical formats: Print version:: Microbial Efflux PumpsDDC classification:
  • 616.9041
LOC classification:
  • QR177 .M53 2013
Online resources:
Contents:
Intro -- Contents -- Contributors -- Preface -- Ch 01: Transmembrane Molecular Transporters Facilitating Export of Molecules from Cells and Organelles -- Ch 02: Structures of Multidrug Efflux Pumps from the MFS, SMR, MATE and ABC Transporter Families -- Ch 03: The Machinery and Mechanism of Multidrug Efflux in Gram-negative Bacteria -- Ch 04: Structure, Mechanism and Assembly of the Tripartite CusCBA Heavy Metal Efflux Complex -- Ch 05: RND Efflux Pumps for Metal Cations -- Ch 06: The Role of Efflux Pumps in the Nosocomial Pathogens Staphylococcus aureus and Acinetobacter baumannii -- Ch 07: Mycobacterium tuberculosis Drug Efflux Pumps: An Update -- Ch 08: Salmonella Efflux Pumps -- Ch 09: Pseudomonas aeruginosa Efflux Pumps -- Ch 10: Function and Regulation of Neisseria gonorrhoeae Efflux Pumps -- Ch 11: Multidrug Efflux Transporters in Campylobacter -- Index.
Summary: Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms.
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Intro -- Contents -- Contributors -- Preface -- Ch 01: Transmembrane Molecular Transporters Facilitating Export of Molecules from Cells and Organelles -- Ch 02: Structures of Multidrug Efflux Pumps from the MFS, SMR, MATE and ABC Transporter Families -- Ch 03: The Machinery and Mechanism of Multidrug Efflux in Gram-negative Bacteria -- Ch 04: Structure, Mechanism and Assembly of the Tripartite CusCBA Heavy Metal Efflux Complex -- Ch 05: RND Efflux Pumps for Metal Cations -- Ch 06: The Role of Efflux Pumps in the Nosocomial Pathogens Staphylococcus aureus and Acinetobacter baumannii -- Ch 07: Mycobacterium tuberculosis Drug Efflux Pumps: An Update -- Ch 08: Salmonella Efflux Pumps -- Ch 09: Pseudomonas aeruginosa Efflux Pumps -- Ch 10: Function and Regulation of Neisseria gonorrhoeae Efflux Pumps -- Ch 11: Multidrug Efflux Transporters in Campylobacter -- Index.

Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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