Management of Urologic Cancer : Focal Therapy and Tissue Preservation.

Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Chapter 1 Cancer Genetics, Cancer Biology, and Tumor Growth and Metastasis:: The Interaction of Cancer and Its Host Environment -- Renal Cell Carcinoma -- Premalignant Lesions -- Molecular Pathogenesis -- Bladder Cancer -- Cell-Cycle Regulation -- FGFR3 and Receptor Tyrosine Kinases -- Molecular Grading -- Prostate Cancer -- Epidemiology -- Molecular Pathogenesis: Inflammation and Genomic and Protein Alterations -- Gene Expression and Molecular-Modeling Concepts -- References -- Chapter 2 Pathological Basis of Tumor Characterization: Cytopathology, Surgical Pathology, and How Histo-Morphology Informs Treatment Decision Making -- The Prostate -- The Kidney -- The Urothelium -- The Testis -- References -- Chapter 3 The Immunobiology of Tumor Ablation -- Manipulating the Immune System to Fight Cancer -- Can We Take Advantage of Ablative Therapies to Activate the Immune System? -- Immunomodulatory Properties of HIFU -- Immunomodulatory Properties of Cryotherapy -- Immunomodulatory Properties of Radiation Therapy -- References -- Chapter 4 Computed Tomography of Urologic Malignancies: The Role of MDCT in Renal Cell Carcinoma and Transitional Cell Carcinoma -- Introduction -- MDCT Protocol Design -- Three-Dimensional Reconstructions -- Neoplasms of the Intrarenal Collecting Systems, Ureters, and Bladder -- Transitional Cell Carcinoma -- Other Less Common Tumors of the Collecting Systems, Ureters, and Bladder -- Solid Renal Parenchymal Lesions -- Renal Cell Carcinoma -- Oncocytoma -- Angiomyolipomas -- Evaluation of Small Renal Masses -- Infiltrative Renal Masses: Lymphoma and Transitional Cell Carcinoma -- Conclusion -- References -- Chapter 5 MRI and Metabolic Imaging -- Magnetic Resonance Imaging -- MRI Sequences -- Clinical Applications of MRI for Prostate Cancer.

Introduction -- mpMRI in Men with Suspected Prostate Cancer -- mpMRI for Planning Focal Treatment for Prostate Cancer -- Intraoperative mpMRI for Guiding Prostate Cancer Focal Therapy -- MRI in the Follow-Up of Prostate Cancer Focal Therapy -- Clinical Applications of MRI for Renal Cancer -- Clinical Applications of MRI for Bladder Cancer -- New Advances in MRI -- Whole-Body MRI -- Hyperpolarized 13-C MRI -- Metabolic Imaging -- Introduction -- Bone Scan -- PET-CT -- Clinical Applications of PET-CT for Prostate Cancer -- FDG -- Choline -- Acetate -- 18F-FACBC -- 18F-FDHT -- Radiolabeled Antibodies to PSMA -- Renal Cancer -- FDG -- Acetate -- Radiolabeled Antibodies -- Clinical Applications of PET-CT for Bladder Cancer -- FDG -- Choline -- Novel Advances in PET Imaging: PET-MRI -- Summary -- References -- Chapter 6 Biopsy Strategies in the Analysis of Urologic Neoplasia -- Kidney -- Background -- The Evolution and Performance of Renal Biopsy -- Biopsy in the Settings of Diagnosis, Focal Therapy, or Metastatic Disease -- Current Challenges -- Laparoscopic Biopsy -- Future Directions -- Penile -- Introduction -- Assessing Nodal Involvement at Time of Diagnosis -- Nodal Involvement after Primary Resection -- Prostate -- Background -- The Refinement of Needle-Guided Biopsy -- Issues with TRUS-Guided Biopsy -- Transperineal Biopsy -- MRI-Guided Biopsy -- Alternative Prostate Biopsy Modalities -- Seminal Vesicle Biopsy -- Testis -- Background -- Assessment of the Contralateral Testicle -- Urothelium -- Bladder -- Upper-Tract Urothelial Carcinoma -- Primary Urethral Carcinoma -- References -- Chapter 7 Active Surveillance for Low-Risk Prostate Cancer -- Introduction and Background -- Rationale -- Genetic Features of Low-Grade Prostate Cancer -- Metastatic Potential -- Biomarkers -- Limitations of PSA Kinetics -- Role of MRI.

Implications for Patient Management -- Eligibility for Surveillance -- Who Is a Candidate? -- Outcome of Surveillance -- Modeling -- AS in Practice -- Conclusions -- References -- Chapter 8 Tissue-Preserving Surgical Approaches in Urologic Oncology: The Therapeutic Mechanism for Tumor Ablation -- Introduction -- Cryoablation: Extreme Cold for Tumor Necrosis -- History -- Mechanism of Action -- Current and Future Trends -- Conclusion -- References -- Chapter 9 Focal Therapy for Prostate Cancer: An Evidence-Based Approach to Tissue‐Preserving Strategies -- Introduction -- Key Concepts in FT for PCa -- Patient Selection for FT -- PCa Lesion Detection for FT -- Follow up after FT -- Tissue-Preserving FTs -- Cryotherapy -- Primary Focal Cryotherapy -- Salvage Focal Cryotherapy -- HIFU -- Primary Focal HIFU -- Salvage Focal/Hemiablation HIFU -- IRE -- Radiation -- Primary Focal Radiotherapy -- Salvage Focal Radiotherapy -- Additional Therapies -- Implications for Research -- Conclusions -- References -- Chapter 10 The Modern Basis for Nephron-Sparing Surgery in Patients with Renal Cancer: Biologic Heterogeneity, the Significance of Tumor Biopsy, and the Changing Roles of Partial Nephrectomy and Tumor Ablation -- Introduction -- Principal Treatment Options for SRMs and the Basis for Nephron Preservation -- Comparative Effectiveness of Radical versus NSS -- Impact of PN and RN on Survival -- Rationale for Ablative Therapies -- CA and RFA -- Follow-up of Renal Ablation -- Outcomes of Renal Ablation -- Other Ablative Techniques -- Treatment Trends for Stage I RCC -- The Role of RMB -- RMB: Safety -- RMB: Diagnostic Accuracy for Malignancy -- RMB: Inaccuracy -- Challenges Posed by Intratumoral Heterogeneity -- Conclusions -- References.

Chapter 11 Bladder-Preserving Strategies in the Treatment of Urothelial Cancer: The Disease Spectrum and the Dawn of Molecular Surgical Guidance -- Augmented Cystoscopy -- Fiber-Optic Probe Technology -- OCT -- CLE -- RS -- Conclusion -- References -- Chapter 12 Image-Guided Thermal Ablation of Adrenal Malignancies -- Introduction -- Clinical Results -- Preprocedural Evaluation -- Technical Considerations -- RFA -- Microwave Ablation -- Cryoablation -- Complications -- Follow-up -- Conclusion -- References -- Chapter 13 Managing Penile Cancer: Integrating Tissue Preservation, Energy-Based Therapeutics, and Surgical Reconstruction -- Introduction -- Description -- Diagnosis and Staging -- Treatment -- Primary Tumor of Low Adverse Prognostic Risk -- Primary Tumor of High Adverse Prognostic Risk -- Regional Lymph Node Metastasis -- Surgical Procedures -- Partial and Total Penectomy -- Wide Local Excision -- Neophalloplasty -- References -- Chapter 14 Testis Cancer: Testis-Sparing Cancer Surgery -- Introduction -- Imaging of Testicular Tumors -- Bilateral Tumors -- The Advent of Testis-Sparing Surgery -- Concerns about TSS -- Presence of Intratubular Germ Cell Neoplasia or Multifocal Invasive Germ Cell Tumor -- Accuracy of FSE -- Preexisting Infertility in Men with Germ Cell Tumors -- The Importance of Aesthetics -- Development of Antisperm Antibodies -- Indications for TSS -- Criteria in Previous Studies and Guidelines -- Preoperative Considerations and Surgical Technique -- Postoperative Care and Follow-Up -- Considerations Regarding Surgical Technique -- The Impact of Cold/Warm Ischemia Compared with No Ischemia -- Use of Intraoperative Ultrasound -- Use of Microsurgical Technique -- Hook Wire Localization and Enucleation -- Outcomes of TSS -- Oncologic Outcomes -- Fertility and Hypogonadism Outcomes -- Summary -- References.

Chapter 15 Nanotechnology: An Evolution in Tissue Preservation and Focal-Targeted Oncologic Therapy -- Introduction -- Introduction to Nanotechnology -- Types of Nanoparticles -- Delivery and Use of Nanoparticles -- Nanotechnology in Prostate Cancer -- Imaging in Prostate Cancer -- Therapeutics in Prostate Cancer -- Nanotechnology in Renal Cancer -- Nanotechnology in Other Urologic Cancers -- Limitations of Nanoparticles -- Future Directions and Conclusions -- References -- Chapter 16 Trial Design Issues in the Study of Focal Therapy in Prostate and Kidney Cancer -- Issues around Endpoints in Studies of Focal Therapy -- Prostate Cancer -- Kidney Cancer: Small Renal Masses -- Functional Outcomes -- Issues around Defining the Study Population and the Control Arms of Comparative Studies in Focal Therapy -- Prostate Cancer -- SRMs -- Issues around Selecting the Optimal Study Design in Focal Therapy -- Conclusion -- References -- Index -- EULA.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.