The Pancreas : An Integrated Textbook of Basic Science, Medicine, and Surgery.

Intro -- Title Page -- Copyright Page -- Contents -- Contributors -- Preface -- Abbreviations -- About the Companion Website -- Section 1 Anatomy of the Pancreas -- Chapter 1 Development of the Pancreas and Related Structures -- Anatomy of the Pancreas -- Organogenesis in the Region of the Pancreas -- Early Pancreatic Development -- Differentiation of Pancreas Cell Types -- Transcriptional Mechanisms Underlying Pancreatic Cell Fate Decision -- Development and Disease -- Acknowledgment -- References -- Chapter 2 Anatomy, Histology, and Fine Structure of the Pancreas -- Introduction -- Gross Anatomy -- Histology and Ultrastructure -- Endocrine Pancreas -- Acknowledgments -- References -- Chapter 3 Congenital and Inherited Anomalies of the Pancreas -- Introduction -- Primary Malformations -- Isolated Congenital Disorders of Pancreatic Endocrine Function -- Other Hereditary Disorders with Variable Pancreatic Involvement and Metabolic Diseases Affecting the Pancreas -- Inherited Metabolic Disorders Affecting the Pancreas -- References -- Section 2 Physiology and Pathophysiology of Pancreatic Functions -- Chapter 4 Physiology of Acinar Cell Secretion -- Introduction -- Composition of Pancreatic Acinar Juice -- Acinar Fluid and Enzyme Secretion -- Ca2+ Signaling -- Organelles Important for Ca2+ Homeostasis -- Mechanisms of Ca2+ Signal Generation -- Ca2+ Entry and Exit -- Ca2+-Mediated Control of Enzyme Secretion -- Ca2+-Mediated Control of Fluid Secretion -- Dangers of Ca2+ Signaling -- References -- Chapter 5 Physiology of Duct Cell Secretion -- Introduction -- Sequential Secretion by Acinar and Duct Cells -- Regulation of Ductal Secretion -- The Ca2+ and cAMP Pathways Synergize to Activate Ductal Secretion -- Ductal Secretion-Associated Pancreatic Diseases -- Acknowledgment -- References -- Chapter 6 Pathophysiology of Experimental Pancreatitis.

Introduction -- Models of Acute Pancreatitis -- Phases of Acute Pancreatitis -- Early Intra-Acinar Events in Acute Pancreatitis -- Conclusion -- References -- Chapter 7 Physiology and Pathophysiology of Function of Sphincter of Oddi -- Introduction -- Anatomy and Morphology -- Innervation -- Physiology -- Motility of the Sphincter of Oddi -- Sphincter of Oddi Motility Studies in Animals -- Sphincter of Oddi Motility in Humans -- Pathophysiology of the Sphincter of Oddi Dysfunction (SOD) -- Conclusion -- References -- Chapter 8 Neurohormonal and Hormonal Control of Pancreatic Secretion -- Introduction -- Stimulation of Pancreatic Secretion -- Inhibition of Pancreatic Secretion -- Feedback Regulation of Pancreatic Secretion -- Conclusion -- References -- Chapter 9 Regulation of Pancreatic Protein Synthesis and Growth -- Introduction -- Regulation of Protein Synthesis -- Regulation of Pancreatic Growth -- References -- Chapter 10 Fibrogenesis in the Pancreas: The Role of Stellate Cells -- Introduction -- Pancreatic Stellate Sells (PSC) -- Acute Pancreatitis -- Chronic Pancreatitis -- Pancreatic Cancer -- Conclusion -- References -- Chapter 11 Fibrogenesis of the Pancreas: The Role of Macrophages -- Introduction -- Macrophages -- Origin and Characteristics of Pancreatic Macrophages -- Role of Macrophages in Chronic Pancreatitis-Associated Fibrosis -- Role of Macrophages in Pancreatic Cancer-Associated Fibrosis -- Conclusion -- References -- Chapter 12 Insulo-Acinar Relationship -- Introduction -- Structural Relationships Between Pancreatic Islets and Exocrine Pancreas -- Insulo-Acinar Portal System -- Regulation of Pancreatic Exocrine Secretion by Islet Hormones -- Pancreatic Exocrine Function and Diabetes Mellitus -- References -- Section 3 Acute Pancreatitis -- Chapter 13 Epidemiology and Etiology of Alcohol‐Induced Pancreatitis -- Introduction.

Epidemiology -- Pathogenesis -- Summary -- Acknowledgment -- References -- Chapter 14 Epidemiology and Etiology of Acute Biliary Pancreatitis -- Introduction -- Etiology of Gallstone Pancreatitis -- Epidemiology of Biliary Acute Pancreatitis -- References -- Chapter 15 Genetic Factors in Acute Pancreatitis -- Introduction -- Genetic Susceptibility Factors -- Multiple Genetic Defects and Susceptibility -- Progression to Chronic Pancreatitis -- Future Directions -- References -- Chapter 16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis -- Introduction -- Role of the Intestine and Mesenteric Lymph in Multiple Organ Dysfunction Syndrome -- Role of the Intestine in Severe Acute Pancreatitis -- Altered Gut-Lymph Composition in Acute Pancreatitis -- Gut-Lymph Toxicity in Acute Pancreatitis -- Translating the Gut-Lymph Concept to Clinical Treatments for Acute Pancreatitis -- Conclusion -- References -- Chapter 17 The Role of Neurogenic Inflammation in Pancreatitis -- References -- Chapter 18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis -- Introduction -- Molecular and Biochemical Abnormalities -- Metabolic and Systemic Abnormalities -- Electrocardiographic Abnormalities in Acute Pancreatitis -- References -- Chapter 19 Histopathology of Acute Pancreatitis -- Introduction -- Definition -- Histopathologic Patterns of Tissue Necrosis -- Acute Pancreatitis with Type 1 Necrosis Pattern -- Acute Pancreatitis with Type 2 Necrosis Pattern -- Acute Pancreatitis with Type 3 Necrosis Pattern -- Histopathology Related to Etiologic Factors and Pathophysiologic Mechanisms -- Unsolved Questions -- References -- Chapter 20 Clinical Classification Systems of Acute Pancreatitis -- Introduction -- Reasons for Classifying the Severity of Acute Pancreatitis.

New Classification Systems -- Validation and Comparison of Classification Systems -- Future of Classification Systems -- Conclusions -- References -- Chapter 21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis -- Introduction -- Historical Perspectives: Approaches to Severity Assessment -- Dynamics of Organ Failure -- Multiparameter Scoring Systems -- Laboratory Variables -- Overview -- References -- Chapter 22 Acute Pancreatitis Associated With Congenital Anomalies -- Introduction -- Pancreas Divisum -- Anomalous Pancreaticobiliary Ductal Union -- Choledochal Cyst/Choledochocele -- Annular Pancreas -- Ectopic Pancreatic Tissue -- Enteric Duplication Cysts -- Conclusions -- References -- Chapter 23 Acute Pancreatitis in Children -- Introduction -- Incidence -- Etiology -- Pathophysiology -- Investigations -- Diagnosis -- Imaging -- Management -- Outcomes -- Acute Recurrent Pancreatitis -- References -- Chapter 24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs -- Introduction -- Metabolic Diseases -- Infectious Diseases -- Drug-Related Diseases -- References -- Chapter 25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis -- Introduction -- Classification of Acute Pancreatitis -- Radiographic Diagnosis of Severe Acute Pancreatitis -- Diagnosis of Local Complications of Acute Pancreatitis -- Radiologic Staging of Severe Acute Pancreatitis -- Limitations and Pitfalls of Radiological Diagnosis of Acute Pancreatitis -- References -- Clinical Course and Medical Treatment of Acute Pancreatitis -- Chapter 26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition -- Introduction -- Fluid Resuscitation -- Enteral and Parenteral Nutrition -- Conclusions -- References -- Chapter 27 ICU Treatment of Severe Acute Pancreatitis.

Introduction -- Pre‐ICU Management -- Special Considerations -- Indications for ICU Admission -- ICU Treatment of Severe Acute Pancreatitis -- Early ICU Management (0-48 Hours from Onset of Pain) -- Management of Metabolic Derangements -- Late ICU Management (&gt -- 48 Hours After the Onset of Pain) -- Management of Infectious Risks -- Transition Planning -- References -- Chapter 28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations -- Introduction -- Infectious Complications -- Spectrum of Bacteria -- Rationales for Antibiotics in Acute Pancreatitis -- Clinical Studies with Antibiotics -- Indications for Antibiotic Treatment -- Limitations of Antibiotic Treatment -- References -- Interventional and Surgical Management of Acute Pancreatitis -- Chapter 29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis -- Introduction -- Interventions for Pancreatic Necrosis: Historical Perspective -- Indications and Timing of Intervention -- Pancreatic Necrosis with Infection -- Symptomatic Pancreatic Necrosis/Walled-Off Necrosis -- Surgical and Interventional Procedures -- Surgical Debridement -- Percutaneous Catheter Drainage -- Direct Endoscopic Necrosectomy -- References -- Chapter 30 Management of Infected Pancreatic Necroses: An Endoscopic Approach -- Pancreatic Necrosis -- Mechanical Intervention -- Transmural Drainage -- Results of Endoscopic Therapy of Pancreatic Necrosis -- Adverse Events of Endoscopic Therapy of Pancreatic Necrosis -- References -- Chapter 31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis -- Introduction -- Technique -- Techniques for Complex Collections -- Early Complications -- Postoperative Course -- Outcome -- References -- Chapter 32 Open Surgical Debridement in Necrotizing Pancreatitis -- Introduction -- General Technique of Open Surgical Debridement.

Continuous Closed Lavage.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.