Mucosal Immunology.

e9780124158474v1.pdf -- Front Cover -- Mucosal Immunology -- Copyright -- In Memoriam -- Contents -- Contributors -- Preface to the First Edition -- Preface to the Second Edition -- Preface to the Third Edition -- Preface to the Fourth Edition -- Historical Aspects of Mucosal Immunology -- MUCOSAL MICROBIOTA -- HEALING POWERS OF SECRETIONS: HISTORY OF BREASTFEEDING -- ANTIBODIES OF EXTERNAL SECRETIONS -- ANATOMIC STUDIES OF MUCOSAL ORGANS AND THEIR FUNCTIONAL IMPLICATIONS -- MUCOSAL VACCINATION -- ORAL TOLERANCE -- IMMUNOPATHOLOGY -- CODA -- REFERENCES -- Section A - Development and Organization of the Mucosal Immune System -- Chapter 1 - Overview: The Mucosal Immune System -- INTRODUCTION -- MUCOSAL MICROBIOTA -- EPITHELIAL CELLS AS ESSENTIAL PARTNERS OF THE MUCOSAL IMMUNE SYSTEM -- ANTIGEN UPTAKE AND PRESENTATION IN THE MUCOSAL IMMUNE SYSTEM -- MUCOSAL T CELLS AND CELL-MEDIATED IMMUNITY -- MUCOSAL IMMUNITY AND HOMEOSTASIS -- UNIQUE FEATURES OF INDIVIDUAL COMPONENTS OF THE MUCOSAL IMMUNE SYSTEM AND THEIR INTEGRATION -- GLOBAL IMPACT OF MUCOSAL IMMUNITY IN VACCINE INITIATIVES -- THE FUTURE -- Chapter 2 - Development and Physiology of the Intestinal Mucosal Defense -- DEVELOPMENT OF MUCOSAL DEFENSE -- THE DEVELOPMENT OF MUCOSAL IMMUNITY CONTINUES DURING THE POSTNATAL PERIOD -- PHYSIOLOGY OF MUCOSAL DEFENSE -- MACROMOLECULAR ABSORPTION -- PHYSIOLOGIC TRANSPORT -- BARRIERS PREVENTING PATHOLOGIC TRANSPORT -- REFERENCES -- Chapter 3 - Development of Gut-Associated Lymphoid Tissues -- INTRODUCTION: GUT-ASSOCIATED LYMPHOID TISSUES -- LYMPH NODE AND PEYER'S PATCH ORGANOGENESIS -- SOLITARY INTESTINAL LYMPHOID TISSUES -- REFERENCES -- Chapter 4 - Structure, Organization, and Development of the Mucosal Immune System of the Respiratory Tract -- INTRODUCTION AND BASIC ANATOMY OF LYMPHOID TISSUES IN THE RESPIRATORY TRACT -- LYMPHOID ARCHITECTURE OF NALT.

NALT DEVELOPMENT -- ANTIGEN ACQUISITION IN NALT -- IMMUNE RESPONSES IN NALT -- NALT AND NASAL TOLERANCE -- LYMPHOID ARCHITECTURE OF BALT -- BALT DEVELOPMENT -- ANTIGEN ACQUISITION IN BALT -- IMMUNE RESPONSES IN BALT -- BALT AND ASTHMA -- BALT AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE -- BALT AND AUTOIMMUNITY -- BALT AND PULMONARY MALIGNANCY -- REFERENCES -- Chapter 5 - The Mucosal Microbiome: Imprinting the Immune System of the Intestinal Tract -- COMPOSITION OF THE INTESTINAL MICROBIOME -- FACTORS INFLUENCING THE INTESTINAL MICROBIOME -- SENSING OF THE MICROBIOTA BY THE INTESTINAL IMMUNE SYSTEM -- INFLUENCE OF THE MICROBIOTA ON IMMUNE DEVELOPMENT AND FUNCTION -- OUTLOOK -- REFERENCES -- Chapter 6 - The Microbiome at Other Mucosal Sites -- INTRODUCTION -- THE ORAL MICROBIOME -- THE AIRWAY MICROBIOME -- THE OCULAR MICROBIOME -- THE GENITAL MICROBIOME -- CONCLUSIONS -- REFERENCES -- Chapter 7 - Endogenous Microbiota of the Genitourinary Tract -- INTRODUCTION -- EARLY STUDIES OF VMB ON THE BASIS OF CULTURE AND MICROSCOPY -- MOLECULAR MICROBIOLOGIC INVESTIGATIONS OF VMB -- MODULATION OF THE VAGINAL MUCOSAL IMMUNE RESPONSE BY VMB -- MOLECULAR ANALYSIS OF MALE GENITOURINARY TRACT MICROBIOTA -- CONCLUSIONS -- REFERENCES -- Chapter 8 - Gnotobiology and the Study of Complex Interactions between the Intestinal Microbiota, Probiotics, and the Host -- INTRODUCTION: MICROBIOTA AND MICROBIOMES -- GNOTOBIOLOGY AS A TOOL: A HISTORICAL PERSPECTIVE -- MICROBIOTA PERTURBATIONS IN HUMAN DISEASE -- MECHANISMS OF IMMUNOMODULATION BY SPECIFIC MEMBERS OF THE INTESTINAL MICROBIOTA -- MECHANISMS OF IMMUNOMODULATION BY PROBIOTICS -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9 - Mucosal Immunity in Invertebrates -- INTRODUCTION -- INNATE IMMUNITY OF INVERTEBRATES -- CONCLUSIONS -- REFERENCES.

Chapter 10 - Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue -- INTRODUCTION -- THE PHYLOGENY OF IMMUNE SYSTEMS -- GENERAL CHARACTERISTICS OF MUCOSA-ASSOCIATED LYMPHOID TISSUE IN THE MAJOR VERTEBRATE LINEAGES -- CONCLUSIONS -- REFERENCES -- Chapter 11 - Ontogeny of Mucosal Immunity and Aging -- ONTOGENY OF MUSCOSAL IMMUNOLOGY -- AGING -- ASSOCIATION OF ONTOGENY PROFILES WITH DISEASE -- CONCLUSIONS -- REFERENCES -- Chapter 12 - Epithelial Cells: Structure, Transport, and Barrier Function -- INTRODUCTION -- STRUCTURAL ORGANIZATION OF THE INTESTINE -- INTESTINAL EPITHELIAL CELL TYPES -- EPITHELIAL POLARITY -- THE PARACELLULAR BARRIER -- TRANSEPITHELIAL TRANSPORT -- MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS -- MEASURING BARRIER FUNCTION -- EX VIVO AND IN VITRO MEASURES OF BARRIER FUNCTION -- BARRIER FUNCTION AND DISEASE PATHOGENESIS -- MODELS LINKING INTESTINAL BARRIER LOSS TO EXPERIMENTAL IBD -- INTESTINAL BARRIER LOSS PROMOTES COMPENSATORY IMMUNOREGULATORY PROCESSES -- CONCLUSION -- REFERENCES -- Chapter 13 - M Cells: Specialized Antigen Sampling Cells in the Follicle-Associated Epithelium -- FUNDAMENTALS OF STRUCTURE AND FUNCTION OF INTESTINAL EPITHELIUM -- STRUCTURE AND CELLULAR COMPOSITION OF INTESTINAL ABSORPTIVE EPITHELIUM -- FUNCTIONS OF INTESTINAL ABSORPTIVE EPITHELIUM -- THE FAE OF GALTS -- MORPHOLOGICAL IDENTIFICATION OF M CELLS -- MARKERS FOR IDENTIFICATION OF M CELLS -- ONTOGENY OF M CELLS -- M CELL DIFFERENTIATION -- FUNCTIONS OF INTESTINAL M CELLS -- M CELLS IN OTHER MUCOSA-ASSOCIATED LYMPHOID TISSUES -- CONCLUSION -- REFERENCES -- Chapter 14 - Mucins and Mucus -- INTRODUCTION -- BIOSYNTHESIS AND STRUCTURE OF MUCINS -- DIFFERENTIATION OF MUCUS PRODUCING CELLS AND REGULATION OF MUCIN GENE EXPRESSION -- FUNCTIONAL PROPERTIES OF MUCINS -- SUBVERSION OF MUCIN BARRIERS BY MUCOSAL PATHOGENS AND PARASITES.

MUCINS IN HUMAN MUCOSAL INFLAMMATORY DISEASES -- FUTURE CHALLENGES -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 15 - Innate Humoral Defense Factors -- INTRODUCTION -- PATTERN-RECOGNITION MOLECULES -- LYSOZYME AND HAMLET -- LACTOFERRIN -- PEROXIDASES -- OTHER FACTORS -- REFERENCES -- Chapter 16 - Defensins in Enteric Mucosal Immunity -- ANTIMICROBIAL PEPTIDES AND INNATE IMMUNITY -- CATHELICIDINS -- DEFENSINS: THREE FAMILIES OF CYSTEINE-RICH AMPS -- MUCOSAL ANTIMICROBIAL PROTEINS AND PEPTIDES -- MECHANISMS OF Α-DEFENSIN BACTERICIDAL ACTION -- THE INTESTINAL EPITHELIUM -- PANETH CELLS -- Α-DEFENSIN BIOSYNTHESIS -- PANETH CELL Α-DEFENSINS -- PANETH CELL Α-DEFENSINS AND INNATE MUCOSAL IMMUNITY -- PANETH CELL DEFECTS AND MUCOSAL IMMUNITY -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 17 - Mucosal Immunoglobulins -- INTRODUCTION -- IGS OF THE EXTERNAL SECRETIONS -- IGA STRUCTURE AND ARRANGEMENT OF COMPONENT CHAINS -- BIOSYNTHESIS AND ASSEMBLY OF IGA -- IGA METABOLISM -- REFERENCES -- Chapter 18 - Phylogeny and Comparative Physiology of Mucosal Immunoglobulins -- INTRODUCTION -- PHYLOGENY OF MUCOSAL IG'S IN JAWED VERTEBRATES -- PHYLOGENY OF POLYMERIC IG'S -- PHYLOGENY OF THE POLYMERIC IG RECEPTOR, THE EPITHELIAL TRANSPORTER OF MUCOSAL IG'S -- COMPARATIVE PHYSIOLOGY OF MUCOSAL IG'S -- CONCLUSIONS -- REFERENCES -- Chapter 19 - Immunoglobulin Transport and Immunoglobulin Receptors -- INTRODUCTION -- TRANSPORT OF POLYMERIC IG BY PIGR -- STRUCTURE AND FUNCTION OF PIGR -- REGULATION OF PIGR EXPRESSION -- ORGANIZATION AND REGULATION OF THE PIGR GENE -- PIGR TRAFFICKING AND SIGNALS -- REGULATION OF PIGR TRAFFICKING -- HEPATOBILIARY TRANSPORT OF IGA -- TRANSPORT OF IGG BY THE FCRN -- STRUCTURE AND FUNCTION OF FCRN -- TRANSCYTOSIS OF IGG BY FCRN -- PHYSIOLOGICAL IMPORTANCE OF FCRN-MEDIATED IGG TRANSCYTOSIS.

EXPLOITATION OF THE FCRN-IGG INTERACTION FOR THERAPEUTIC PURPOSES AT MUCOSAL SURFACES -- SYSTEMIC FUNCTIONS OF FCRN -- CONCLUSIONS -- REFERENCES -- Chapter 20 - Fc Receptors in Mucosal Immunology -- INTRODUCTION -- LEUKOCYTE IGA RECEPTORS -- FCΑ/ΜR -- NONLEUKOCYTE IGA RECEPTORS -- FCR-MEDIATED IGE ACTIVITY IN MUCOSAL SECRETIONS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 21 - Biological Activities of IgA -- INTRODUCTION -- BIOLOGICAL PROPERTIES OF IGA -- IGA AND MAINTENANCE OF HOMEOSTASIS -- REFERENCES -- Chapter 22 - Microbial Evasion of IgA Functions -- INTRODUCTION -- SPECIFIC IGA PROTEASES -- OTHER MICROBIAL PROTEASES WITH IGA-CLEAVING ACTIVITY -- EFFECT OF MICROBIAL GLYCOSIDASES ON IGA -- IGA-BINDING PROTEINS -- CONCLUSIONS -- REFERENCES -- Chapter 23 - The Regulation of IgA Production -- VARIABLE IGA PRODUCTION IN MAMMALS -- IMMUNE GEOGRAPHY AND LYMPHOID STRUCTURES REGULATING IGA PRODUCTION -- T CELL-DEPENDENT IGA RESPONSES UPON COLONIZATION WITH A MICROBIOTA -- T CELL-INDEPENDENT IGA GENERATION IN ISOLATED LYMPHOID FOLLICLES -- IGA GENERATION IN LAMINA PROPRIA: INNATE AND ADAPTIVE CROSSROAD -- HETEROGENEITY OF IGA INDUCTION AND RESPONSES -- REFERENCES -- Section B - Inductive and Effector Cellsand Tissues of the MucosalImmune System -- Chapter 24 - Overview: Inductive and Effector Cells and Tissues of the Mucosal Immune System -- Chapter 25 - Mucosal Dendritic Cells: Origins, Subsets, and Biology -- INTRODUCTION -- ORIGINS OF DCS -- DCS ARE SPECIALIZED SENTINELS THAT CAPTURE ANTIGENS AND ACTIVATE NAÏVE T CELLS AFTER MIGRATING TO THE DRAINING LNS -- DENDRITIC CELLS CAN DIRECTLY DETERMINE THE NATURE OF THE ENSUING LYMPHOCYTE RESPONSE -- GASTROINTESTINAL TRACT DCS -- RESPIRATORY TRACT DCS -- GENITOURINARY TRACT DCS -- GENERAL CONCLUSIONS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 26 - Mucosal Macrophages in Defense and Regulation -- INTRODUCTION.

ONTOGENY OF MUCOSAL MACROPHAGES.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.