Bats and Viruses : Current Research and Future Trends.

Intro -- Contents -- 1. Bats and Viruses: Introduction -- Bats and viruses -- Book chapters -- 2. Bats and Flaviviruses -- The Flavivirus genus, a diverse collection of viruses -- Flaviviruses: general characteristics -- Evidence of flavivirus detection and isolation from bats -- Bats as reservoirs of human flaviviruses or accidental hosts? -- Bat-mosquito cycle: are bats a source for mosquito feeding? -- Conclusions -- 3. Alphavirus and Its Vertebrate Hosts -- Introduction -- Alphavirus and rodents -- Conclusions -- 4. Bat Influenza A-like Viruses -- Introduction -- Generation of chimeric bat influenza A-like viruses -- The envelope proteins of bat influenza A-like viruses -- The M2 proteins of bat influenza A viruses -- The polymerase complex of bat influenza A viruses -- The viral nucleoprotein of bat influenza A viruses -- The NS1 protein of bat influenza A viruses -- Is there a zoonotic risk associated with bat IALV? -- Resume -- 5. Bats and Coronaviruses -- Introduction - history of coronavirus discovery -- The coronavirus genome -- Bats as the origin of SARS coronavirus -- Bats as the gene pool of alphacoronaviruses and betacoronaviruses -- Bats as the origin of MERS coronavirus -- Conclusion -- 6. Genetic Diversity and Geographic Distribution of Bat-borne Hantaviruses -- Introduction -- Taxonomy -- Hantavirus disease -- Rodents as reservoir hosts -- Shrews and moles as reservoir hosts -- Bats as reservoir hosts -- Molecular phylogeny -- Discussion -- Future research -- 7. Bat Polyomaviruses: A Challenge to the Strict Host-Restriction Paradigm within the Mammalian Polyomaviridae -- Introduction -- Polyomaviruses are highly host-restricted -- Polyomavirus genomes identified in insectivorous and frugivorous bat species -- Recombination events in the family Polyomaviridae.

Intra-genera transmission of horseshoe bat Polyomaviruses: a challenge to the paradigm of host-restriction within the mammalian Polyomaviridae -- Estimation of time to most recent common ancestor for Rhinolophus PyVs -- Generation and characterization of bat cell lines immortalized with large T antigen -- Discussion -- 8. Innate Immunity in Bats -- Introduction -- The interferon (IFN) response -- Sequencing reveals intact IFN systems but with varying differences in bats versus humans or mice -- Transcriptomics demonstrates expression and inducibility of bat type I IFN responses -- Do bats have altered type I IFN gene expression? -- Type I IFN gene responses beyond IFN-α/-β -- Type III IFN responses are also intact in bats -- Other aspects of bat innate immunity -- Cellular components of innate antiviral immunity -- Conclusions -- 9. Immune (Adaptive) Response in Bats -- Introduction -- Antibody mediated immunity -- Cell-mediated immunity -- Bat major histocompatibility complex (MHC) -- Conclusions and discussion -- Future trends -- 10. In Vitro Isolation of Bat Viruses Using Commercial and Bat-derived Cell Lines -- Introduction -- Cell culture systems for virus isolation -- Virus isolation of bat-borne viruses -- Coronaviruses -- Paramyxoviruses -- Filoviruses -- Rhabdoviruses -- Other families -- Conclusion and future perspectives -- 11. In Vivo Models of Infection -- Introduction -- Challenges of bat husbandry -- Choice of bat species -- Developed bat models -- Conclusions -- 12. Metagenomics for Viral Discovery in Bats -- Introduction -- Bat viromes - an ever-expanding assemblage -- Viral metagenomics methodologies -- Limitations and challenges to overcome -- Future directions and concluding remarks -- 13. Are Bats 'Special'? -- Introduction -- Are bats a true reservoir? -- Are bats special?.

Potential link between adaptation to flight and special virus reservoir status -- Conclusions -- Future directions -- Current Books of Interest -- Index.

In this multi-authored volume, international experts review the current hot-topics in this field. Chapters have extensive reference sections that should encourage readers to pursue each subject in greater detail. The book opens with an introductory chapter that is followed by six chapters (chapters 2-7) reviewing different important families of bat-borne viruses. The following two chapters (chapters 8-9) focus on the bat immune system. Chapters 9-12 cover in vitro isolation, in vivo models and metagenomics for viral discovery in bats. The book closes with a fascinating look at the special ability of bats to act as reservoirs for so many different types of viruses. This book is an invaluable reference source of timely information for students, virologists, immunologists, medical and veterinary professionals, and scientists working on bat-borne diseases. It is also highly recommended for all university libraries.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.