Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors : Diagnosis and Management.

Cover -- Title page -- Copyright page -- Contents -- Contributors -- Preface -- Abbreviations -- PART I: Ductal adenocarcinoma of the pancreas -- CHAPTER 1: Histologic classification and tumor staging of pancreatic cancer -- Histologic classification of pancreatic ductal neoplasms -- Atypical epithelium and carcinoma in situ -- Invasive ductal carcinomas -- Tumor staging -- References -- CHAPTER 2: What we know about carcinogenesis of ductal adenocarcinoma of the pancreas -- Pancreatic cancer cell -- Pancreatic cancer stem cells -- Tumor stroma cells -- References -- CHAPTER 3: Familial cancer of the pancreas -- Introduction -- Definition -- Phenotype -- Pathology -- Genetic background -- Genetic counselling and testing -- Screening -- Candidates and targets for screening -- Current screening modalities -- Timing and frequency of screening -- Success of screening programs -- Management of suspicious lesions -- Psychooncological aspects of PDAC screening -- Conclusion -- References -- CHAPTER 4: Clinical, laboratory, and radiologic presentation of pancreatic cancer -- Clinical presentation -- Laboratory investigations -- Radiologic investigations -- References -- CHAPTER 5: Standards of oncologic pancreatic surgery -- Overview -- Preoperative considerations -- Preoperative biliary drainage -- Imaging -- Staging laparoscopy -- Goals of surgical treatment -- Operative techniques -- Pylorus-preserving pancreatoduodenectomy -- Classic "Whipple" -- Distal pancreatectomy with en bloc splenectomy -- Complete R0 versus R1 resection -- Standard (D1) versus extended (D2) lymphadenectomy -- Minimally invasive pancreatic resections -- Robotic and laparoscopic pancreatoduodenectomy -- Robotic and laparoscopic distal pancreatectomies -- Postoperative course, complications, and adjuvant treatment -- Postoperative recovery.

Postoperative complications and management -- Conclusion -- References -- CHAPTER 6: Extended resection for pancreatic cancer: risks and benefits -- Introduction -- History of portal vein resection -- Diagnosis of cancer invasion of the portal vein -- Indications for portal vein resection -- Isolated pancreatoduodenectomy with portal vein resection -- Mesenteric approach -- Catheter bypass of the portal vein -- Portal vein resection and reconstruction -- Postoperative mortality at Nagoya University Hospital -- Long-term survival following portal vein resection -- References -- CHAPTER 7: Risk/benefit of total pancreatectomy for pancreatic cancer: are there indications? -- Historical notes -- Benefits versus disadvantages -- Pancreatic malabsorption -- Pancreatic diabetes -- New indications -- Modified surgical techniques -- Pylorus-preserving total pancreatectomy -- Total pancreatectomy with preservation of stomach and spleen -- Re-resection for recurrent cancer -- Results of total pancreatectomy -- Rescue pancreatectomy -- Isolated neck margin positive pancreatic adenocarcinoma -- In children -- Total pancreatectomy with islet transplantation -- Conclusion -- References -- CHAPTER 8: Is there a benefit from additional arterial resection of ductal cancer of the pancreas? -- Introduction -- Arterial resection in pancreatectomy following preoperative chemotherapy or chemoradiotherapy -- Distal pancreatectomy with resection of the celiac axis -- References -- CHAPTER 9: Who benefits from ultraradical pancreatic cancer resection? -- Introduction -- Lymphadenectomy for pancreatic head cancer -- Extrapancreatic nerve plexus excision -- Vascular resection -- Multivisceral resection -- Randomized controlled trials of standard versus extended lymphadenectomy in radical pancreatoduodenectomy -- References.

CHAPTER 10: Risk and results of pancreatic cancer resection -- The appropriate patient and the appropriate clinic-probably the most important presupposition of successful pancreatic surgery -- Preoperative risk evaluation of the patient -- The center effect and the surgeon's experience -- General and specific surgical aspects of operative and perioperative measures to reduce complications -- Preoperative preparations -- Operative methods and operation-specific risk factors -- Complications and their management after pancreatic surgical procedures -- Early postoperative complications -- Late morbidity after pancreatic surgery -- References -- CHAPTER 11: Pancreatic cancer: the role of bypass procedures -- Obstructive jaundice -- Bypass surgery for obstructive jaundice -- Surgical versus endoscopic or percutaneous drainage for obstructive jaundice -- Gastric outlet obstruction -- Bypass surgery for gastric outlet obstruction -- Laparoscopic palliation in selected patients -- Bypass versus palliative resection -- Conclusion -- References -- CHAPTER 12: Evidence of adjuvant chemotherapy of ductal pancreatic cancer -- Introduction -- Rationale for adjuvant chemotherapy -- Randomized controlled trials of adjuvant chemotherapy -- Systemic chemotherapy -- Evidence of adjuvant chemoradiotherapy -- Randomized controlled trials of adjuvant chemoradiation -- Rationale for adjuvant combination therapy -- Randomized controlled trials of adjuvant combination therapy -- Meta-analyses -- Conclusions -- Future directions -- References -- CHAPTER 13: Neoadjuvant chemotherapy and radiochemotherapy: is there a survival advantage for pancreatic cancer patients? -- Introduction -- Surgery first followed by adjuvant therapy: overview of clinical trials, lack of progress, and reasons why -- Surgery after induction therapy: pros and cons of the neoadjuvant approach.

Importance of accurate pretreatment staging: eligibility for clinical trials must be standardized -- Neoadjuvant therapy for resectable pancreatic cancer: evidence in support of a survival advantage -- Neoadjuvant treatment schemas for resectable disease: current recommendations from the Medical College of Wisconsin -- Neoadjuvant therapy for borderline resectable pancreatic cancer: consensus has developed in support of this approach -- Neoadjuvant treatment schemas for borderline resectable disease: current recommendations from the Medical College of Wisconsin -- Pretreatment molecular diagnostics as a guide to neoadjuvant therapy: is the future now? -- Conclusions -- References -- CHAPTER 14: Standards of palliative chemotherapy and chemoradiotherapy of local advanced pancreatic cancer, side effects, and survival benefits -- Introduction -- Locally advanced PC: palliative chemoradiotherapy -- Concurrent chemoradiotherapy compared with radiation alone -- Chemoradiation compared with chemotherapy alone -- Chemoradiotherapy compared with best supportive care -- Locally advanced PC: palliative chemotherapy -- References -- CHAPTER 15: Management of local and distant recurrence after pancreatic cancer resection -- Introduction -- Rate and site of recurrence after pancreatic resection -- Management of local recurrence -- Surgery for local recurrence -- Chemotherapy with or without radiotherapy for local recurrence -- Management of distant recurrence -- Conclusion -- References -- CHAPTER 16: Survival 3, 5, and 10 years after adjuvant regional and neoadjuvant chemotherapy in resectable pancreatic cancer patients: an institutional experience -- Introduction -- Actual 3- and 5-year survival after pancreatic cancer resection -- Patients who survived more than 5 years postoperatively -- Comment -- References.

CHAPTER 17: Nonductal primary malignancies of the pancreas: acinus cell carcinoma -- Introduction -- Clinical presentation -- Diagnostic investigations -- Treatment -- Conclusion -- References -- CHAPTER 18: Nonductal primary malignancies of the pancreas: metastatic malignancies -- Overview -- Burden of disease -- Diagnosis and evaluation -- Patient selection for metastasectomy -- Operative approach -- Primary neoplasms metastatic to the pancreas -- Renal cell carcinoma -- Colorectal carcinoma -- Sarcoma -- Melanoma -- Safety and efficacy of metastasectomy -- References -- PART II: Periampullary cancers -- CHAPTER 19: Histopathology of tumors of the ampulla of Vater -- Adenoma -- Epidemiology -- Pathological findings -- Immunohistochemistry -- Prognosis -- Invasive carcinoma of the ampullary region -- Epidemiology -- Pathological findings -- Immunohistochemistry -- Prognosis -- Neuroendocrine neoplasm of the ampulla of Vater -- Epidemiology -- Pathological findings -- Mesenchymal tumors of the ampullary region -- Secondary tumors -- References -- CHAPTER 20: Clinical approach to periampullary cancer -- Clinical presentation: most-frequent and rare clinical symptoms -- Jaundice -- Weight loss -- Pain -- Acute cholangitis and acute pancreatitis -- Diagnostic protocol, fast track, and regular diagnostic procedures -- Laboratory investigation -- Carbohydrate antigen 19-9 -- Carcinoembryonic antigen -- Hepatocyte growth factor -- Standard radiologic procedures for diagnosis and staging -- Transabdominal ultrasonography -- Computed tomography -- Magnetic resonance cholangiopancreatography -- Endoscopic retrograde cholangiopancreatography -- Percutaneous transhepatic cholangiography -- Endoscopic ultrasonography -- Staging laparoscopy -- Positron emission tomography (PET) or PET-CT -- References.

CHAPTER 21: Adenoma of the papilla of Vater and endoscopic management.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.