Tissue Engineering : Engineering Principles for the Design of Replacement Organs and Tissues.

Intro -- Contents -- Part 1 Tissue Exchange and Tissue Development -- 1 The State-of-the-Art in Tissue Exchange -- 1.1 History -- 1.2 Prospects for the Future -- References -- 2 Objecives of Tissue Engineering -- 2.1 Tissue Engineering Is an Alternative to Drug Therapy, Gene Therapy, and Whole-Organ Transplantation -- 2.2 Tissue Engineering Attempts to Inspire or Control the Normal Processes of Tissue Repair and Healing -- 2.3 Tissue Engineering Attempts to Replace Cells that are Missing Within an Otherwise Functional Tissue or Organ -- 2.4 Tissue Engineering Uses Cellular Control Mechanisms to Enhance Drug Delivery -- 2.5 Tissue Engineering Leads to New Models of Human Physiology -- 2.6 Tissue Engineering -- Summary -- Exercises -- References -- 3 Elements of Tissue Development -- 3.1 Early Transformations in the Embryo -- 3.2 Control of Development -- 3.3 Mechanisms of Development -- Summary -- Glossary -- Exercises -- References -- Part 2 Tissue Engineering Fundamentals -- 4 Cell Growth and Differentiation -- 4.1 The Cell Cycle -- 4.2 Stem Cells and Cell Differentiation -- 4.3 Agents that Regulate Cell Growth and Differentiation -- 4.4 Trafficking and Signal Transduction -- 4.5 Kinetics of Cell Proliferation -- Summary -- Exercises -- References -- 5 Cell and Tissue Mechanics -- 5.1 Elementary Solid Mechanics -- 5.2 Elementary Fluid Mechanics -- 5.3 Mechanical Properties of Biological Fluids and Gels -- 5.4 Mechanical Properties of Cells -- 5.5 Mechanical Properties of Tissues -- Summary -- Exercises -- References -- 6 Cell Adhesion -- 6.1 Mechanics of Cell Adhesion -- 6.2 Cell Junctions -- 6.3 Cell Adhesion Receptors -- 6.4 Extracellular Matrix -- 6.5 Cell Adhesion and Intracellular Signalling -- Summary -- Exercises -- References -- 7 Cell Migration -- 7.1 Overview of Cell Migration -- 7.2 Experimental Observations on Cell Motility.

7.3 Quantitative Methods for Describing the Movement of Individual Cells -- 7.4 Quantitative Methods for Describing the Movement of Cell Populations -- 7.5 Mean Time to Capture -- 7.6 Coordination of Cell Migration -- Summary -- Appendix: Additional Information on Brownian Motion and Random Walks -- Exercises -- References -- 8 Cell Aggregation and Tissue Equivalents -- 8.1 Overview and Significance -- 8.2 Cell Aggregation and Cell Sorting -- 8.3 Models of Cell Aggregation -- 8.4 Cell-Populated Tissue Equivalents -- Summary -- Exercises -- References -- 9 Tissue Barriers to Molecular and Cellular Transport -- 9.1 Mobility of Lipids and Proteins in the Membrane -- 9.2 Permeation of Molecules through Membranes -- 9.3 Permeation of Molecules through Cell Layers -- 9.4 Permeation of Cells through Cell Layers -- Summary -- Exercises -- References -- Part 3 Tissue Engineering Practice -- 10 Cell Delivery and Recirculation -- 10.1 Cell Movement within the Circulatory System -- 10.2 Examples of Cell Trafficking between Body Compartments -- 10.3 Microchimerism -- 10.4 Cell Penetration into Three-Dimensional Tissues -- Summary -- Acknowledgment -- Exercises -- References -- 11 Delivery of Molecular Agents in Tissue Engineering -- 11.1 Technology for Controlled Delivery of Molecular Agents in Tissue Engineering -- 11.2 Controlled Release of Agents in Time and Space -- 11.3 Future Applications of Controlled Delivery in Tissue Engineering -- Summary -- Exercises -- References -- 12 Cell Interactions With Polymers -- 12.1 Characterizing Cell Interactions with Polymers -- 12.2 Cell Interactions with Polymer Surfaces -- 12.3 Cell Interactions with Polymers in Suspension -- 12.4 Cell Interactions with Three-dimensional Polymer Scaffolds and Gels -- Summary -- Exercises -- References -- 13 Approaches to Tissue Engineering -- 13.1 Artificial Organs.

13.2 Roles of the Synthetic Component -- 13.3 Control of the Biological Component -- 13.4 Replacement of Tissue Structure or Function -- Summary -- Exercises -- References -- 14 Case Studies in Tissue Engineering -- 14.1 Tissue-Engineered Cartilage -- 14.2 Tissue-Engineered Skin -- 14.3 Tissue-Engineering Approaches for Nerve Regeneration -- References -- Appendices -- A: Introduction to Polymers -- A.1 Polymer Properties -- A.2 Non-degradable Polymers -- A.3 Biodegradable Polymers -- A.4 Water-Soluble Polymers -- References -- B: Analysis of Molecular Transport -- B.1 Random Walks -- B.2 Equations for the Diffusive Flux (Fick's Law) -- B.3 Equations of Mass Conservation (Fick's Second Law) -- B.4 Solutions to the Diffusion Equation with no Solute Elimination or Generation -- References -- C: Useful Data -- C.1 Protein Properties -- C.2 Blood and Tissue Cell Properties -- C.3 Mathematical Tables and Functions -- References -- D: Nomenclature and Abbreviations -- D.1 Nomenclature -- D.2 Abbreviations -- D.3 Glossary -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.

PrefaceWhat it means to meHow To Use This BookPart 1. Tissue Exchange and Tissue DevelopmentReferences2. Objectives of Tissue EngineeringSummary/References/Exercises3. Elements of Tissue DevelopmentSummary/References/ExercisesPart 2. Tissue Engineering Fundamentals4. Cell Growth and DifferentiationSummary/References/Exercises5. Cell and Tissue MechanicsSummary/Refences/Exercises6. Cell AdhesionSummary/References/Exercises7. Cell MigrationSummary/Endnote/References/Additional information on Brownian Motion and Random Walks/Exercises8. Cell Aggregation and Tissue EquivalentsSummary/References/Exercises9. Tissue Barriers to Molecular and Cellular TransportSummary/References/ExercisesPart 3. Tissue Engineering Practice10. Cell Delivery and RecirculationSummary/Endnote/References/Exercises11. Delivery of Molecular Agents in Tissue Engineering*Summary/Endnote/References/Exercises12. Cell Interactions With PolymersSummary/Endnote/References/Exercises13. Approaches to Tissue EngineeringSummary/Endnote/References/Exercises14. Case Studies in Tissue EngineeringReferences/AppendicesA. Introduction to PolymersReferencesB. Analysis of Molecular TransportReferencesC. Useful DataReferencesD. Nomenclature and Abbreviations.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.