The Bacteriocins : Current Knowledge and Future Prospects.

Intro -- Contents -- Contributors -- Current Books of Interest -- Preface -- Foreword -- 1: The Natural History of Bacteriocins -- Introduction -- The frequency of bacteriocin production -- Genotype effects -- Bacteriocin release: lysis versus excretion -- Multiple bacteriocin production -- Invasion dynamics of secreted bacteriocins -- Conclusions -- 2: Microcins and Other Bacteriocins: Bridging the Gaps Between Killing Strategies, Ecology and Applications -- Introduction -- A brief description of bacteriocins, defence weapons of bacteria -- Killing strategies of bacteriocins -- How to make and maintain efficient weapons: from biosynthetic pathways to bioengineering -- Immunity of the producers to their toxic peptides -- Ecological roles of bacteriocins -- Bridging the gaps between biosynthesis, killing strategies, ecology and applications -- 3: Nuclease Colicins: Mode of Action, Immunity and Mechanism of Import into Escherichia coli -- Overview of colicins and their import into E. coli -- Colicin structures -- Mechanism of action of nuclease colicin cytotoxic domains -- Affinity and specificity of nuclease colicin immunity protein complexes -- Receptor binding -- Translocator recruitment and the delivery of signalling epitopes to the periplasm -- Colicins recruit periplasmic proteins to form a translocon at the outer membrane -- Isolation of the ColE9 translocon reveals an unexpected path for the IUTD through the translocator OmpF -- The role of the proton motive force in colicin outer membrane translocation -- Colicin nuclease domain translocation across the inner membrane and the role of proteolytic processing -- Future perspectives -- 4: Capturing the Power of van der Waals Zone in the Creation of a Novel Family of Bacteriocin-based Antibiotics -- Looking to bacteria in our quest for novel antibiotics.

The channel-forming bacteriocins provide a novel platform for creating antibiotics with designer specificities -- Expanding the bacterial killing breadth of pheromonicins -- Using van der Waals interactions to target eukaryotic cells -- The emerging pheromonicin platform -- Conclusions and future directions -- 5: The Use of Pyocins in Treating Pseudomonas aeruginosa Infections -- Introduction -- Pyocins: bacteriocins of P. aeruginosa -- Possible use of pyocins in treatment of P. aeruginosa infections -- Concluding remarks -- 6: Streptococcal Bacteriocin-producing Strains as Oral Probiotic Agents -- Introduction -- The salivaricins of Streptococcus salivarius -- Commercial development of oral streptococci for use as oral probiotics -- Concluding remarks -- 7: Treating Bovine Mastitis with Nisin: A Model for the Use of Protein Antimicrobials in Veterinary Medicine -- Introduction -- Mastitis - a challenging infection in the dairy industry -- Current treatments and resistance landscape -- Nisin - the next generation antimicrobial for mastitis control -- The hurdles of developing a protein-based therapy -- Future work -- Conclusion -- 8: The Phenotypic and Genotypic Landscape of Colicin Resistance -- Introduction -- Materials and methods -- Results -- Discussion -- Index.

In this volume, a range of experts explore our current understanding of the biology of these important compounds, and identify the prospects for their use in medical and veterinary applications. In so doing, this volume introduces the vast diversity of bacteriocin molecules and mechanisms and brings readers to the cutting edge of a new 21st century approach to antibiotic discovery and design. Topics covered include: the natural history of bacteriocins; killing strategies and applications of microcins; the mode of action of nuclease colicins; the role of the van der Waals zone in the design of a new family of bacteriocins; the use of pyocins in the treatment of infections; the role of streptococccal bacteriocins as oral probiotics; veterinary applications of bacteriocins (nisin) in treating mastitis, and an exploration of the genetics of bacteriocin resistance. This volume is essential reading for everyone involved in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.