Clinical Virology.

Cover -- Half-Title Page -- Title Page -- Copyright Page -- DEDICATION -- Contents -- Contributors -- Conflicts of Interest -- Preface -- Important Notice (Please Read) -- 1. Introduction -- ACKNOWLEDGMENTS -- REFERENCES -- Section I: Viral Syndromes and General Principles -- 2. Respiratory Infections -- SEASONAL PATTERNS OF RESPIRATORY VIRUS INFECTION -- COMMON COLDS -- Clinical Features and Syndrome Definition -- Etiology and Differential Diagnostic Features -- Pathogenesis -- Treatment and Prevention -- Clinical Features and Syndrome Definition -- Etiology and Differential Diagnostic Features -- Pathogenesis -- Treatment and Prevention -- CROUP (ACUTE LARYNGOTRACHEOBRONCHITIS) -- Clinical Features and Syndrome Definition -- Etiology and Differential Diagnostic Features -- Pathogenesis -- Treatment and Prevention -- BRONCHIOLITIS -- Clinical Features and Syndrome Definition -- Etiology and Differential Diagnostic Features -- Pathogenesis -- Treatment and Prevention -- TRACHEITIS AND TRACHEOBRONCHITIS -- Clinical Features and Syndrome Definition -- Etiology and Differential Diagnostic Features -- Treatment and Prevention -- VIRAL PNEUMONIA -- Clinical Features and Syndrome Definition -- Diagnosis -- Pathogenesis -- Treatment and Prevention -- REFERENCES -- 3. Viral Infections of the Central Nervous System -- VIRAL MENINGITIS -- Epidemiology -- Clinical Manifestations -- Laboratory Findings -- Etiologic Diagnosis -- Differential Diagnosis -- Treatment and Prognosis -- VIRAL ENCEPHALITIS -- Epidemiology and Prevalence -- Pathogenesis -- Clinical Manifestations -- Laboratory Findings and Diagnosis -- Differential Diagnosis -- Prevention -- Treatment -- Approach to Patients with Viral CNS Disease -- ACKNOWLEDGMENT -- REFERENCES -- 4. Gastrointestinal Syndromes -- INTRODUCTION -- HISTORICAL BACKGROUND -- VIRAL AGENTS -- EPIDEMIOLOGY.

CLINICAL MANIFESTATIONS AND PATHOGENESIS -- HIGH-RISK GROUPS -- OTHER VIRAL AGENTS OF GASTROENTERITIS -- ASSOCIATED DISEASES -- DETECTION METHODS -- TREATMENT AND PREVENTION -- REFERENCES -- 5. Viral Hepatitis -- Historical Perspectives -- Epidemiology -- PATHOPHYSIOLOGY -- CLINICAL FEATURES -- Acute Viral Hepatitis -- Role of Liver Biopsy -- SPECIAL POPULATIONS -- Transmission in Healthcare Workers -- Hepatitis in Pregnancy -- Viral Hepatitis in the HIV Population -- Hepatitis in Patients Undergoing Immunosuppressive Therapy -- REFERENCES -- 6. Viral Infections in Organ Transplant Recipients -- CYTOMEGALOVIRUS INFECTION -- Epidemiology, Risk Factors, and Pathogenesis of CMV Disease -- EPSTEIN-BARR VIRUS INFECTION -- Epidemiology, Risk Factors, and Pathogenesis of EBV Disease -- Immune Monitoring for EBV Risk -- HUMAN HERPES VIRUSES TYPE 6 AND TYPE 7 -- Epidemiology, Risk Factors, and Pathogenesis of CMV Disease -- Clinical CMV Disease, Treatment, and Prevention -- HUMAN HERPES VIRUS TYPE 8 -- Epidemiology, Risk Factors, and Pathogenesis of CMV Disease -- Clinical HHV-8 Disease, Treatment, and Prevention -- OTHER HERPESVIRUSES -- Herpes Simplex Virus and Varicella Zoster Virus -- POLYOMAVIRUS INFECTIONS IN TRANSPLANT RECIPIENTS -- BK Virus Infection -- JC Virus Infection -- REFERENCES -- 7. Viral Heart Disease -- ETIOLOGY -- EPIDEMIOLOGY -- PATHOGENESIS -- Animal Model Studies -- Human Observations -- Pathophysiologic Consequences -- PATHOLOGY -- Gross Findings -- Findings by Microscopy -- CLINICAL MANIFESTATIONS -- Newborns and Infants -- Children, Adolescents, and Adults -- DIAGNOSTIC EVALUATION -- Chest Radiography -- Electrocardiography -- Echocardiography, Ventriculography, and Magnetic Resonance Imaging -- Blood Tests -- Endomyocardial Biopsy -- The Dallas Criteria -- Viral Studies -- DIFFERENTIAL DIAGNOSIS -- LONG-TERM SEQUELAE.

SUPPORT FOR VIRAL CAUSE-AND-EFFECT RELATIONSHIP WITH MYOCARDITIS -- MANAGEMENT -- Management of Acute Heart Failure Related to Myocarditis -- Immunomodulatory and Antiviral Therapies -- Vaccination -- REFERENCES -- 8. Viral Diseases of the Skin -- CLINICAL MANIFESTATIONS -- PATHOPHYSIOLOGY -- DIAGNOSIS -- Laboratory Diagnosis -- Differential Diagnosis -- LOCAL IMMUNITY TO VIRAL INFECTIONS -- DNA VIRUSES -- Human Papillomaviruses -- Poxviruses -- Human Herpesviruses-Herpes Simplex Virus (HSV-1, HSV-2) -- Varicella-Zoster Virus -- Epstein Barr Virus -- Cytomegalovirus -- Human Herpesviruses-HHV-6 and HHV-7 -- Human Herpesvirus 8 -- B Virus (Herpesvirus Simiae) -- Parvovirus B19 -- RNA VIRUSES -- Enteroviruses -- Measles Virus -- Rubella Virus -- Hepatitis C -- Human Immunodeficiency Virus -- REFERENCES -- 9. Viral Hemorrhagic Fevers -- HISTORICAL PERSPECTIVES -- CAUSATIVE AGENTS -- EPIDEMIOLOGY -- PATHOGENESIS -- CLINICAL MANIFESTATIONS -- DIAGNOSIS -- CLINICAL MANAGEMENT -- Infection Prevention and Control -- Supportive Care -- Antiviral Treatment -- PREVENTION -- Transmission Reduction Strategies -- Vaccines -- REFERENCES -- 10. Viral Disease of the Eye -- ANATOMY AND PHYSIOLOGY -- MAJOR CLINICAL SYNDROMES -- Conjunctivitis -- Keratitis -- Scleritis and Episcleritis -- Uveitis -- Retinitis -- Ocular Adnexal Disease -- VIRAL OCULAR PATHOGENS -- HIV and the Eye -- Herpesviruses -- Adenoviruses -- Picornaviruses -- Measles -- Poxviruses -- Vaccinia Virus -- Human Papillomavirus -- Ocular Disorders Associated with Systemic Viral Illness -- REFERENCES -- 11. Antiretroviral Agents -- HIV-1 ENTRY INHIBITORS -- Enfuvirtide -- CCR5 Antagonists -- INVESTIGATIONAL HIV-1 ENTRY INHIBITORS -- BROADLY NEUTRALIZING MONOCLONAL ANTIBODIES -- NUCLEOSIDE ANALOG REVERSE TRANSCRIPTASE INHIBITORS -- Zidovudine -- Lamivudine -- Abacavir -- Emtricitabine.

Mechanism of Action -- SELECTED INVESTIGATIONAL NRTIS -- NUCLEOTIDE ANALOG REVERSE TRANSCRIPTASE INHIBITORS -- Tenofovir Disoproxil Fumarate (See also Tenofovir Alafenamide) -- Tenofovir Alafenamide -- NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS -- Nevirapine -- Efavirenz -- Etravirine -- Rilpivirine -- INVESTIGATIONAL NNRTIS -- INTEGRASE STRAND TRANSFER INHIBITORS -- Raltegravir -- Elvitegravir -- Dolutegravir -- INVESTIGATIONAL INTEGRASE INHIBITORS -- HIV PROTEASE INHIBITORS -- Lopinavir (Coformulated with Ritonavir) -- Tipranavir -- Darunavir -- INVESTIGATIONAL HIV-1 PROTEASE INHIBITORS -- PHARMACOENHANCERS -- Ritonavir -- Cobicistat -- MATURATION INHIBITORS -- REFERENCES -- 12. Antiherpesvirus Agents -- ANTIHERPESVIRUS AGENTS -- Acyclovir -- Valacyclovir -- Famciclovir and Penciclovir -- Brivudine -- Trifluridine -- Ganciclovir -- Valganciclovir -- Foscarnet -- Cidofovir -- Other Antiherpesvirus Agents -- Investigational Antiherpesvirus Agents -- REFERENCES -- 13. Anti-Hepatitis Virus Agents -- ANTIVIRAL AGENTS FOR HEPATITIS B INFECTION -- Lamivudine -- Emtricitabine -- Adefovir Dipivoxil -- Resistance -- Entecavir -- Telbivudine -- Tenofovir Disoproxil Fumarate -- Tenofovir Alafenamide Fumarate -- ANTIVIRAL AGENTS FOR HEPATITIS C VIRUS INFECTION -- Interferons -- Ribavirin -- Direct-Acting Agents: NS5B Inhibitors -- Sofosbuvir -- Dasabuvir -- Beclabuvir -- GS-9669 -- Direct-Acting Agents: NS3/4A Inhibitors -- Simeprevir -- Paritaprevir -- Grazoprevir -- Pharmacology -- Asunaprevir -- Vedroprevir -- GS-9857 -- Glecaprevir (ABT-493) -- Direct-Acting Agents: NS5A Inhibitors -- Daclatasvir -- Ledipasvir -- Ombitasvir -- Elbasvir -- Velpatasvir -- Pibrentasvir (ABT-530) -- Ravidasvir (PPI-668) -- Direct-Acting Agents: Other Mechanisms -- Alisporivir -- REFERENCES -- 14. Antirespiratory Virus Agents -- INFLUENZA VIRUS -- Amantadine -- Rimantadine.

Zanamivir -- Oseltamivir -- Peramivir -- RESPIRATORY SYNCYTIAL VIRUS -- Palivizumab -- Ribavirin -- INVESTIGATIONAL AGENTS -- REFERENCES -- 15. Diagnosis of Viral Infections -- SPECIMENS -- CELL CULTURE -- Standard Cell Cultures -- Cytopathic Effect -- Shell Vial Culture -- Mixed Cell Cultures -- Genetically Engineered Cell Lines -- ANTIVIRAL SUSCEPTIBILITY TESTING -- Introduction -- Phenotypic Assays -- Genotypic Assays -- DIRECT DETECTION OF VIRUS OR VIRAL ANTIGEN -- Immunoassays -- Histopathology/Cytopathology -- Electron Microscopy -- NUCLEIC ACID DETECTION -- Polymerase Chain Reaction (PCR) Assay -- Extraction of Nucleic Acid from Specimens -- Detection of Amplicons -- Multiplex PCR -- Real-Time PCR -- Fully Integrated Automated Systems -- Non-PCR-Based Nucleic Acid Amplification Systems -- Controls -- Application of Nucleic Acid Testing in Virology -- Routine Diagnosis of Virus Infection -- Diagnosis of Novel and Emerging Viral Infections -- Diagnosis of Chronic Viral Infections -- Viral Diagnosis in the Management of Immunocompromised Patients -- Monitoring Response to Antiviral Therapy and Antiviral Drug Resistance -- Nucleic Acid Sequencing -- SERODIAGNOSIS OF VIRAL DISEASES -- Antibody Response to Viral Infections -- Specimens for Serodiagnosis -- Procedures for Detecting Viral Antibodies -- Complement Fixation -- Hemagglutination Inhibition -- Neutralization -- Immune Adherence Hemagglutination -- Immunofluorescence Assays -- Solid-Phase Immunoassays -- Passive Latex Agglutination Assays -- Immunoblot Assays -- Immunochromatographic Assays -- IgM Antibody Determination -- Interpretation of Serology Test Results -- QUALITY ASSURANCE AND QUALITY CONTROL -- Quality Assurance -- Quality Control -- REFERENCES -- 16. Immune Responses to Viral Infection -- THE IMMUNE SYSTEM -- Barrier Immunity -- Innate Immunity -- The Complement System.

Innate Immune Recognition of Viruses.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.