Diabetes Mellitus : A Fundamental and Clnical Text.

Cover -- Copyright -- Editors -- Preface -- Contents -- Part I - Insulin Secretion -- 1 - The Two Phases of Glucose-Stimulated Insulin Secretion Mechanisms and Controls -- 2 - Insulin Gene Regulation -- 3 - Processing of the Insulin Molecule -- 4 - Electrophysiology of the Pancreatic β-Cell -- 5 - Sulfonylurea Receptors, Adenosine triphosphate-Sensitive Potassium Channels, and Insulin Secretion -- 6 - Insulinotropic Glucagon-Like Peptides -- 7 - Detrimental Effects of Chronic Hyperglycemia on the Pancreatic β-Cell -- 8 - Glucose Toxicity of the β-Cell Cellular and Molecular Mechanisms -- 9 - Lipotoxicity -- 10 - Islet Amyloid in Type 2 Diabetes -- Part II - Insulin Action -- 11 - Physiologic Action of Insulin -- 12 - Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations -- 13 - Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia -- 14 - The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation -- 15 - The Insulin Signaling Network and Insulin Action -- 16 - Knockout Mice as a Tool to the Understanding of Diabetes Mellitus -- 17 - Regulation of Insulin Action by Protein-Tyrosine Phosphatases -- 18 - Small GTPAses and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction -- 19 - Protein Kinase C -- 20 - Regulation of Glycogen Synthesis -- 21 - Insulin Action on Glucose Transport -- 22 - Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation -- 23 - Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes -- 24 - Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion -- 25 - Gene Regulation -- 26 - Insulin Degradation -- 27 - Insulin and the Ras-Dependent Signaling Pathway.

28 - Germline Manipulation of Glucose Transport and Glucose Homeostasis -- 29 - Molecular Links Between Peroxisome Proliferator-Activated Receptor-γ and Metabolic Disease -- Part III - Definition and Classification -- 30 - Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis -- Part IV - Type 1 Diabetes Mellitus -- 31 - The Natural History of Autoimmunity in Type 1A Diabetes Mellitus -- 32 - Genetics of Type 1 Diabetes -- 33 - Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus -- 34 - Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus -- 35 - Major Histocompatibility Locus and Other Genes that Determine the Risk for Development of Type 1 Diabetes Mellitus -- 36 - Associations Between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases -- 37 - Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus -- 38 - Animal Models of Autoimmune Diabetes Mellitus -- 39 - Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes -- 40 - Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome -- Part V - Therapeutics for Type 1 Diabetes Mellitus -- 41 - Application of the Diabetes Control and Complications Trial -- 42 - Diet Therapy in Type 1 Diabetes Mellitus -- 43 - Exercise for the Patient with Type 1 Diabetes Mellitus -- 44 - Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus -- 45 - Immune Intervention -- 46 - Islet Cell Transplantation -- 47 - Islet Transplantation -- 48 - Pancreas Transplantation -- 49 - Gene Therapy for Metabolic Disease -- 50 - Surrogate β-cells for Insulin Replacement Therapy -- 51 - Stem Cells -- Part VI - Type 2 Diabetes Mellitus -- 52 - Epidemiology of Type 2 Diabetes Mellitus -- 53 - Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus.

54 - Noninvasive Imaging of Insulin Action and Resistance in Humans -- 55 - Genetics of Human Obesity -- 56 - Obesity: Treatment -- 57 - Obesity in Type 2 Diabetes Mellitus -- 58 - Effects of Aging on Glucose Homeostasis -- 59 - Drug-Induced Diabetes Mellitus -- 60 - Insulin Secretion in Type 2 Diabetes Mellitus -- 61 - Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome -- 62 - Glucose Transporters and Pathophysiologic States -- 63 - Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action -- 64 - Inflammation, Tumor Necrosis Factor-α, and Insulin Resistance -- 65 - Adipokines: Regulators of Metabolic Integration and Energy Metabolism -- 66 - Fatty Acids and Insulin Resistance -- 67 - Triglyceride in Muscle -- 68 - Candidate Genes for Type 2 Diabetes Mellitus -- 69 - Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipoatrophic Diabetes -- 70 - Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus -- 71 - Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus -- 72 - Primate Animal Models of Type 2 Diabetes -- Part VII - Therapeutics for Type 2 Diabetes Mellitus -- 73 - Preventing Type 2 Diabetes: The Diabetes Prevention Program -- 74 - Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load -- 75 - Exercise in Patients with Type 2 Diabetes Mellitus -- 76 - Insulin Secretagogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives -- 77 - Metformin -- 78 - Peroxisome Proliferator-Activated Receptor Modulators -- 79 - &amp -- alpha -- -Glucosidase Inhibitors in the Treatment of Diabetes -- 80 - Glinides -- 81 - Combination Therapy in Type 2 Diabetes Mellitus -- 82 - Intensive Insulin Therapy for Patients with Type 2 Diabetes -- 83 - Hypoglycemia in Type 2 Diabetes Mellitus.

84 - New Therapies to Promote Insulin Action -- Part VIII - Pregnancy -- 85 - Intermediary Metabolism During Pregnancy: Implications for Diabetes Mellitus -- 86 - Effects of Maternal Diabetes Mellitus on Intrauterine Development -- 87 - Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications -- 88 - Gestational Diabetes Mellitus -- Part IX - Descriptive and Clinical Complications -- 89 - Pathophysiology of Diabetic Retinopathy -- 90 - Pathogenesis of Diabetic Nephropathy -- 91 - Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment -- 92 - Diabetes Mellitus, Lipids, and Atherosclerosis -- 93 - Pathophysiology of Hypertension in Diabetes -- 94 - Macrovascular Complications of Diabetes Mellitus -- 95 - Skin and Diabetes -- 96 - Neonatal Diabetes Mellitus -- 97 - Hypoglycemia in the Adult -- Part X - Mechanisms of Complications -- 98 - Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism -- 99 - Hyperinsulinemia and Insulin Resistance -- 100 - The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications -- 101 - Oxidative Stress, Inflammation, and Diabetic Complications -- 102 - Diabetic Vasculopathy -- Color Plates -- Index.

Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.