Scientific and Engineering Principles : Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25 1980.

Front Cover -- Scientific and Engineering Principles -- Copyright Page -- Table of Contents -- Editorial Board -- PREFACE -- GUEST EDITORIAL I. IBIOCHEMICAL ENGINEERING: WHERE HAS IT BEEN AND WHERE IS IT GOING? -- TECHNOLOGY-PULL" AND "SCIENCE-PUSH -- CURRENT STATE OF BIOCHEMICAL ENGINEERING -- SOME SUGGESTIONS AND PROPOSALS -- REFERENCES -- GUEST EDITORIAL II. GENETICS AND INDUSTRIAL MICROBIOLOGY: STILL FURTHER HORIZONS -- Section I:Microbial Cultures: Screening,Improvement, Patents -- Chapter 1 . STRAIN IMPROVEMENT PROGRAMS IN ANTIBIOTIC-PRODUCING MICROORGANISMS- PRESENT AND FUTURE STRATEGIES -- ABSTRACT -- KEYWORDS -- INTRODUCTIO -- RATIONAL SELECTION PROCEDURES -- POTENTIALS FOR R-DNA TECHNOLOGY IN MICROBIAL SELECTION -- REFERENCES -- Chapter 2. NEW ORGANISMS OF ECONOMIC IMPORTANCE: THE CASE OF FRANKIA -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- LEGUMES -- ACTINOMYCETES -- CONCLUSIONS -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 3. MIXED CULTURES IN INDUSTRIAL PROCESSES D.E.F. Harrison -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ADVANTAGES OF MIXED CULTURES FOR SCP PRODUCTION -- OTHER APPLICATIONS OF MIXED CULTURES -- DISADVANTAGES OF MIXED CULTURES -- FUTURE PROSPECTS -- REFERENCES -- Chapter 4. CULTURES AND PATENTS Roman Saliwanchik -- ABSTRAGT -- KEYWORDS -- DISCUSSION -- CONCLUSION -- REFERENCES -- Chapter 5. PRODUCTION OF PHARMACOLOGICALLY ACTIVE AGENTS FROM MICROBIAL ORIGIN -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- I. PROTEASE INHIBITORS -- II. GLYCOSIDASE INHIBITORS -- III. INHIBITORS OF HYDROLYTIC ENZYMES LOCATED ON THE CELL SURFACE -- REFERENCES -- Chapter 6. SCREENING OF BASIDIOMYCETES FOR THE PRODUCTION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 7. SCREENING OF BACTERIAL ISOLATES FOR ANTIGONOCOCCAL ACTIVITIES -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- SCREENING.

CRUDE PREPARATIONS -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 8. ISOLATION OF CARBOXYL PROTEINASES OF MICROBIAL ORIGIN ON PEPSTATIN-SEPHAROSE RESIN -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- Chaptre 9. RAPID STRAIN SELECTION FOR CITRIC ACID PRODUCTION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 10. USE OF CERULENIN IN SELECTING IMPROVED MUTANTS OF A DAUNORUBICIN-PRODUCING STREPTOMYCETE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- Chapter 11. IMPROVEMENT OF THE DAUNORUBICIN FERMENTATION REALIZED AT 10,000 LITER FERMENTOR SCALE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- METHOD OF ASSAY FOR DAUNORUBICIN -- FERMENTATION -- RECOVERY -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 12. STUDIES ON THE AVERMECTIN FERMENTATION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- Chapter 13. THE INFLUENCE OF OXYGEN CONCENTRATION ON MICROBIAL INSECTICIDE PRODUCTION -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS, DISCUSSION AND CONCLUSIONS -- NOMENCLATURE -- REFERENCES -- Section II Recombinant DNA and Microbial Genetics -- Chapter 14. ENZYMATIC HYDROLYSIS OF SOME PENICILLINS AND CEPHA-L OSPORINS BY CLONED ESCHERICHIA COLI ACYLASE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- Chapter 15. EXPANSION OF THE HOST RANGE OF P1 AND Mu PHAGES AND GENE TRANSFER BETWEEN INTERGENERIC BACTERIA -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- BACTERIAL STRAINS, PHAGE, AND MEDIA -- EXTENSION OF P1 HOST RANGE AND INTERGENERIC TRANSDUCTION -- COMMENTS FOR IN VIVO GENETIC ENGINEERING -- ACKNOWLEDGEMENT -- REFERENCES.

Chapter 16. STABILITY OF trp OPERON RECOMBINANT PLASMID IN E. c oli -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- REFERENCES -- Chapter 17. GENETIC CONTROL OF DIKARYOTIC FRUITING IN THE BASIDIOMYCETE PLEUROTUS OSTREATUS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- REFERENCES -- Section III Cell and Tissue Culture -Plant and Animal -- Chapter 18. ADVANCES IN PLANT CELL CULTURE TOWARDS IMPROVED YIELDS OF SECONDARY PRODUCTS (ALKALOIDS) -- Chapter 19. ASPECTS ON SCALE-UP AND MASS CULTIVATION OF PLANT TISSUE CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- PROCESS VARIABLES IN SHAKE FLASKS -- STABILIZATION OF PRODUCT YIELD ON SCALING-UP -- SHEAR STRESS AND APPARENT VISCOSITY -- OXYGEN SUPPLY, GAS EXCHANGE -- DISCUSSION -- ACKNOWLEGEMENTS -- REFERENCES -- Chapter 19. ASPECTS ON SCALE-UP AND MASS CULTIVATION OF PLANT TISSUE CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- PROCESS VARIABLES IN SHAKE FLASKS -- STABILIZATION OF PRODUCT YIELD ON SCALING-UP -- SHEAR STRESS AND APPARENT VISCOSITY -- OXYGEN SUPPLY, GAS EXCHANGE -- DISCUSSION -- ACKNOWLEGEMENTS -- REFERENCES -- Chapter 20. PRESENT AND FUTURE TRENDS IN PLANT TISSUE CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- METHODS -- RESULTS AND DISCUSSION -- Chapter 21. EFFECTS OF MEDIA CONSTITUENTS ON THE FORMATION OF SECONDARY PRODUCTS IN CELL SUSPENSION CULTURES OF CATHARANTHUS ROSEUS -- ABSTRACT -- .KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 22. HORMONAL REGULATION OF SCOPOLETIN AND SCOPOLIN PRODUCTIONS IN TOBACCO TISSUE CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- Chapter 23. ENGINEERING CHARACTERIZATION OF ANIMAL CELL AND VIRUS PRODUCTION USING CONTROLLED CHARGE MICROCARRIERS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS.

CONCLUSIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- Section IV Microbial Oxidation of Hydrocarbons -- Chapter 24. UPTAKE AND OXIDATION OF HYDROCARBONS BY A MUTANT DERIVED FROM ITACONATE-PRODUCING YEAST -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- Chapter 25. STUDY OF HYDROXYLASE AND ITS COMPONENTS IN CANDIDA TROPICALIS GROWN ON ALKANE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- HYDROXYLASE REGULATION -- STUDY OF THE ENZYME SYSTEM -- LOCALIZATION OF THE HYDROXYLASE ACTIVITY -- PURIFICATION OF THE ENZYMATIC SYSTEM -- REFERENCES -- Chapter 26. PLASMID INVOLVEMENT IN BACTERIAL DEGRADATION OF PHENANTHRENE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- METHODS -- RESULTS -- DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 27. INDUCTION OF ENZYMES FOR n-ALKANE DEGRADATION IN TWO STRAINS OF Pseudomonas aeruginosa -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- 28. STRUCTURAL CHANGES OF THE TOL PLASMID pWWO -- ABSTRACT -- KEY WORDS -- INTRODUCTION -- SELECTION FOR LOSS OF THE TOL CATABOLIC GENES -- RECOMBINANT RP4:: TOL PLASMIDS -- CONCLUSIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- Chapter 29. UTILIZATION OF N-ALKANES BY MICROORGANISMS:BIOLOGICAL ASPECTS OF TRANSPORT -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- Section V Continuous Cultures -- Chapter 30. THE UTILITY OF CHEMOSTAT CULTURES IN STUDIES OF MICROBIALPHYSIOLOGY -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- GROWTH RATE -- NUTRIENT-LIMITED GROWTH -- REFERENCES -- Chapter 31. CONTINUOUS CULTURE - SOME CONTEMPORARY PROBLEMS FROM ANOTHER VIEWPOINT -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 33. CONTINUOUS CULTURE - ITS INFLUENCE ON ENGINEERING PRACTICE -- ABSTRACT -- KEYWORDS -- INTRODUCTION.

THEORETICAL BACKGROUND TO INDUSTRIAL CONTINUOUS FERMENTATIONS -- LARGE SCALE CONTINUOUS SYSTEMS - BIOMASS PRODUCTION -- CONTINUOUS MULTI-STAGE SYSTEMS WITH BOTH INTERNAL AND EXTERNAL RECYCLE - DENITRIFICATION -- PHOSPHATE REMOVAL - ANAEROBIC-AEROBIC SYSTEMS -- SUMMARY -- REFERENCES -- Chapter 34. THE ENZYME ACTIVITY AS GROWTH RATE LIMITING STEP IN A CHEMOSTAT -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- RESULTS AND DISCUSSION -- REFERENCES -- Chapter 35. SELECTION OF ESCHERICHIA COLI WITH INCREASED ENDOENZYME SYNTHESIS IN CONTINUOUS CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- D-SERIKE DEAMINASE -- RIBITOL DEHYDROGENASE -- PENICILLIN AMIDASE -- REFERENCES -- Chapter 36. CONTINUOUS PROCESS FOR PRODUCTION OF CITRIC ACID -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 37. KINETICS OF VIRUS REPLICATION AND GLUCOAMYLASE BIOSYNTHESIS IN ASPERGILLUS NIGER REPEATED FED- BATCH CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- MATHEMATICAL MODEL -- RESULTS AND DISCUSSION -- REFERENCES -- Chapter 38. AUTO-SELECTION OF VERY RAPIDLY GROWING MICROORGANISMS -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- THEORY -- SELECTION -- ACID-BASE RELATIONSHIPS -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- Chapter 39. GEL-FORMING EXOPOLYSACCHARIDE PRODUCTION BY ALCALIGENES FAECALIS GROWN IN NITROGEN-LIMITED CONTINUOUS CULTURE -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- EXPERIMENTAL RESULTS AND DISCUSSION -- ACKNOWLEDGEMENTS -- REFERENCES -- Chapter 40. NEW DEVELOPMENTS IN THE ELUCIDATION OF THE MECHANISMS OFTHE PASTEUR AND CRABTREE EFFECTS IN BACTERIA -- ABSTRACT -- KEYWORDS -- INTRODUCTION -- PASTEUR EFFECT -- CRABTREE EFFECT -- REFERENCES.

Chapter 41. THE CRABTREE EFFECT IN SACCHAROMYCES CEREVISIAE - PRIMARY CONTROL MACHANISM OR TRANSIENT?.

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