Molecular Biology of Kinetoplastid Parasites.

Intro -- Contents -- Preface -- Current Books of Interest -- About the Editor -- 1. Genome-wide Profiling of Unique Domain Architectures Reveals Novel Epigenetic Regulators of Leishmania infantum -- Introduction -- Results and discussion -- Conclusion -- Materials and methods -- 2. Role of Hypoxia Inducible Factor-1 in Leishmania-Macrophage Interaction: -- Introduction -- Structure of HIF-1 -- Regulation of HIF-1α -- Regulation of HIF-1 activity -- Role of HIF-1 in physiology -- Role of HIF-1 in infection and innate immunity -- HIF-1 as possible drug target in visceral form of leishmaniasis -- 3. Response of B Lymphocytes During Leishmania Infection -- Leishmaniasis -- Immune system elements -- Host immune response -- B-cell development and functions of B-cells -- B-cell pathogenicity during Leishmania infection -- Developmental deregulation of B-cells during pathological condition -- Regulatory B-cells -- Secretion of IL-10 from B-lymphocytes during Leishmania infection -- 4. Cellular Defence of the Leishmania Parasite -- Introduction -- Distribution -- Life cycle -- Treatment -- Challenges in the field of treatment -- Parasite's defence arsenal -- Host manipulation by parasite -- Molecular Regulation of Macrophage Class Switching in Indian Post-kala-azar Dermal Leishmaniasis (PKDL) -- Introduction -- Historical background of PKDL -- Clinical features of PKDL -- Alternative activation of macrophages and disease etiopathogenesis of PKDL -- Status of cytokine milieu in dermal leishmaniasis -- Toll-like receptors in PKDL -- Status of reactive oxygen and nitrogen intermediates in PKDL -- Attenuated phosphorylation of p-38 and ERK in PKDL -- Role of host and parasite arginase 1 in PKDL -- Status of co-stimulatory molecules, CD80/CD 86 in PKDL -- Role of vitamin D in Indian PKDL -- Status of MRC 1 in Indian PKDL.

6. Leishmania Exploits Host's Defence Machineries for Survival: A Tale of Immune Evasion -- Introduction -- Early stages of infection -- Mid stages of infection -- Late stages of infection -- Protecting own niche: prevention of host cell apoptosis -- Ceramide in the Establishment of Visceral Leishmaniasis, an Insight into Membrane Architecture and Pathogenicity -- Introduction -- Pathways of ceramide biosynthesis -- Ceramide an important component of inflammatory response -- Role of ceramide in infectious diseases -- Biphasic role of ceramide during visceral leishmaniasis -- Ceramide-mediated impairment in antigen presentation -- Ceramide mediated regulation of kinases and phosphatises -- Modulation of T-cell subsets through ceramide generation during visceral leishmaniasis -- 8. The Role of Haemproteins in Different Life Cycle Stages of Leishmania -- Introduction -- Haem and haem containing proteins -- Leishmania need haem for survival -- Source of haem and its acquisition systems in Leishmania -- Role of different types of haemproteins in eukaryotes and prokaryotes -- Conclusions -- Future trends -- 9. Pre-adaptation of Leishmania Promastigotes to Intracellular Life: Ensuring a Successful Infection -- Introduction -- Membrane and cytoskeleton-sensing the changes -- Parasite exoproteome-modulating the host -- Cytosolic proteins: a pool of stress busters -- The metabolic adaptations -- The global picture of parasite preadaptation -- Concluding remarks -- 10. DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives -- Introduction -- Different topoisomerases of kinetoplastid parasites -- Exploiting the topoisomerases of kinetoplastid parasites for therapeutic interventions -- Conclusion and future perspectives.

11. Host-Kinetoplastid Parasite Interaction at the Immune System Interface: Immune Evasion and Immunotherapy -- Introduction -- Molecular host-parasite interaction and strategies of immune evasion by the parasite -- Morphological characterization of kinetoplastids -- Leishmania -- Trypanosoma -- Development of immunotherapeuetics -- Vaccination using parasite derived immunogenic components -- Conclusion -- 12. Extracellular Matrix Interacting Proteins of Trypanosomatids: Adhesion and Invasion of Host Tissues -- Introduction -- General overview of extracellular matrix components -- Mechanism of extracellular matrix interaction by the extracellular matrix interacting proteins -- Synopsis -- 13. Effects of Phospholipid Analogues on Trypanosomatids -- Introduction -- Phospholipids and their importance for the cell -- Phospholipids biosynthetic pathways in mammalian cells and in trypanosomatids -- Design and synthesis of phospholipid analogues -- Effect of phospholipid analogues on the growth and morphology of trypanosomatids -- Cell death processes and immunomodulatory effects induced by phospholipid analogues -- A critical view of the use of miltefosine for treatment of leishmaniasis -- Index.

Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. With an emphasis on cellular and molecular biology, areas covered include epigenetic regulation, cellular defence, manipulation of host macrophages, B lymphocyte response, adhesion and invasion of host tissues, immune evasion, immunotherapy, hemeproteins, phospholipids biosynthesis and DNA topoisomerases. A common theme throughout the book is the identification of new therapeutic targets for drug development. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites and will also be of interest to parasitologists, immunologists and drug development researchers. All parasitology laboratories should have a copy of this important reference volume.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.