Transplant Immunology.

Intro -- Title page -- Table of Contents -- Contributors -- Foreword -- Preface -- About the companion website -- CHAPTER 1: Tissues and organs of the immune system -- Introduction -- Primary lymphoid tissues -- Secondary lymphoid tissues -- Tertiary lymphoid tissues -- Summary -- References -- Further reading -- CHAPTER 2: Cells of the immune system -- Introduction -- Innate immune cells -- Natural killer cells -- Adaptive immune cells -- Natural killer T (NKT) cells -- Summary -- Further reading -- CHAPTER 3: Soluble mediators in the immune system -- Introduction -- Cytokines -- Acute phase cytokines -- The IL-1 family cytokines -- The common γc family of cytokines -- The IL-12 family of cytokines -- Adaptive immunity cytokines -- Immunoregulatory cytokines -- Further reading -- CHAPTER 4: Costimulatory molecules -- Introduction -- Costimulatory molecules -- Summary and relevance to clinical transplantation -- References -- CHAPTER 5: Major histocompatibility complex -- Introduction -- Structure and function of MHC -- Anti-HLA antibodies in transplantation -- Non-HLA antigens in organ transplantation -- Summary -- Further reading -- CHAPTER 6: T cells and the principles of immune responses -- Introduction -- T cell activation -- T cell differentiation to effector cells -- Progression from naïve to memory T cells -- Regulatory T cells -- Summary -- Further reading -- CHAPTER 7: Ischemia and reperfusion injury -- Introduction -- Mechanism of organ injury -- Toll-like receptors (TLRs) in innate immune activation during IRI -- Non-TLRs in innate immune activation in IRI -- IL-10 and innate immune activation -- T cells, NK cells, and NKT cells in IRI -- Conclusions -- References -- CHAPTER 8: Immune responses to transplants -- Introduction -- Tranpslant rejection -- Transplant tolerance -- Immune privilege and accommodation -- Summary -- References.

Further reading -- CHAPTER 9: Principles of hematopoietic cell transplantation -- Introduction -- Principles of HCT -- GVHD: Principles -- Acknowledgments -- References -- CHAPTER 10: Therapeutic approaches to organ transplantation -- Introduction -- General aspects of ISDs -- Small-molecule drugs -- Protein drugs and biologics -- Immunosuppression protocols -- Managing antibody-mediated rejection and the positive crossmatch patient -- Tolerance induction strategies -- References -- Further reading -- CHAPTER 11: Organ-specific features in clinical transplantation -- Introduction -- Kidney -- Liver -- Lung -- Heart -- Small bowel -- Conclusion -- Acknowledgment -- References -- CHAPTER 12: Transplant-related complications -- Introduction -- Infections -- Post-transplant malignancy -- Metabolic disorders -- Hypertension -- Hematologic disorders -- Summary -- References -- Further reading -- CHAPTER 13: Biomarkers of allograft rejection and tolerance -- Introduction -- Biomarkers -- Summary -- References -- Further reading -- CHAPTER 14: Emerging issues in transplantation -- Introduction -- Age and immune responses -- Marginal donor organs -- Organs from donors after cardiac or circulatory death (DCD) -- Organ age and its roles in immunogenicity, injury/repair, and immune responses -- Recipient age and transplant outcome -- Immunosuppression in the elderly -- Xenotransplantation -- Artificial or biologic organ replacement -- Liver support systems -- Ventricular assist devices and cardiac regeneration -- Tissue engineering, organ scaffolds, and stem cells -- Summary -- Further reading -- CHAPTER 15: New frontiers and new technologies -- Regenerative medicine: past, present, and future possibilities -- Definition of stem cell concepts -- Sources of stem cells -- Experimental studies and clinical applications -- Future challenges.

Vascularized composite allotransplantation -- Nanotechnology -- Imaging of allografts: nanotechnology and beyond -- Gene therapy in transplantation -- References -- CHAPTER 16: Experimental models in discovery and translational studies -- Introduction -- The need for animal models of transplantation -- Choice of models-small animal models versus large animal models -- Choice of models-organs -- Small animal transplant models (see Table 16.1) -- Large animal transplant models -- Use of experimental models to address key challenges -- Summary and future directions -- Further reading -- Index -- End User License Agreement.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.