Proteomics : Targeted Technology, Innovations and Applications.

Intro -- Contents -- Contributors -- Current books of interest -- Preface -- 1: Serum Proteomics for Studying Disease Pathogenesis and Identification of Disease Biomarkers -- Introduction -- Challenges of serum proteome analysis -- Proteomic techniques in serum profiling -- Applications -- Conclusion -- 2: Serum Profiling by Targeted Proteomics for Biomarker Discovery -- Biomarker discovery -- Targeted proteomics -- Serum profiling by targeted proteomics -- Conclusions -- 3: Targeted Proteomics: Applications in the Study of Liver Disorders -- The liver -- Shotgun proteomics and liver disorders -- MS-based targeted proteomics: selected reaction monitoring for protein detection and quantitation -- Protein regulation: targeted analysis of post-translational modifications based on enrichment procedures -- Concluding remarks and future perspectives -- 4: Targeted Proteomics for Chronic Lymphocytic Leukaemia -- Introduction -- Epidemiology and incidence -- Clinical presentation -- Monoclonal B lymphocytosis (MBL) -- Genetic and epigenetic analysis of CLL -- Proteomics profiles in B-cell malignancies -- Proteome analysis of B-cell maturation -- Quantitative proteomics -- 'shot gun' proteomic studies on B-cell malignancies -- Conclusions and future directions -- 5: Protein Microarrays: A Versatile Tool for Scientific Discovery -- Introduction -- Basic research applications -- Clinical research applications -- Data analysis and bioinformatics -- Outlook and perspective -- 6: Bioinformatics Challenges in Targeted Proteomics -- Introduction -- Experimental design -- Data acquisition and data processing -- Noise reduction and normalization -- Data interpretation -- 7: Standardized Formats, Report Information Guidelines, Mass Spectrometry-based Repositories and Application Programming Interfaces for Implementing Data Standards in Proteomics.

Background: HUPO-PSI -- Standardization pillars: MIAPE guidelines, XML-based standard formats and controlled vocabularies -- Proteomics repositories and databases -- Application Programming Interfaces (APIs) for the integration of data standards into laboratory pipelines -- Bioinformatics tools for creating and managing proteomics data standards -- Data analysis and reporting tools -- Conclusions -- 8: Clinical Protein Science and Targeted Mass Spectrometric Assays - New Frontiers in Disease Link and Biobanking -- The unmet needs and progresses in modern healthcare -- Building new medical frontiers in modern society -- Impact to society of personalized medicines -- Biobanking -- Protein biomarkers and targeted analysis -- Prostate cancer protein biomarker analysis -- Conclusions -- Index.

In this book a panel of high-profile authors provides an overview of targeted proteomics in biomedical science. The book is focused on current, state-of-the-art technology and applications and is a valuable source of information for everyone working in this field. The first part of the book provides detailed examples of the application of targeted proteomics in biomarker discovery and pathogenesis. The second part is focused on the various tools used in targeted proteomics including bioinformatics approaches while the final section is dedicated to biobanks, a vital aspect of targeted proteomics. This volume is highly recommended for anyone interested in proteomics, disease pathogenesis, clinical protein science and biomarker discovery.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.