Infections of the Central Nervous System : Pathology and Genetics.

Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Chapter 1 Introduction and Classification of Infections of the CNS According to the Agent -- Reference -- Chapter 2 Sepsis-Associated Encephalopathy -- Definition of the disorder, major synonyms, and historical perspective -- Epidemiologic characteristics -- Predictive factors -- Consequences for survival -- Consequences for long‐term cognitive dysfunction -- Clinical features including appropriate investigations -- Clinical examination -- SAE blood markers -- EEG -- Brain imaging -- Physiopathology -- Ischemic processes -- Neurotransmission impairment and neurotoxicity -- Consequences for cell status -- Treatment, future perspective, and conclusions -- References -- Chapter 3 Variation of CNS Infections According to the Host -- Introduction -- Primary and congenital immunodeficiency -- Acquired immunodeficiencies and opportunistic infections -- OIs of the CNS in patients with granulocytic disorders -- OIs of the CNS in patients with combined granulocytic and lymphocytic disorders -- OIs of the CNS in patients with lymphocytic disorders -- Immune reconstitution inflammatory syndrome -- Intrauterine infection -- CNS infections in neonates and children -- References -- Chapter 4 Clinical Approach to the Adult Patient with CNS Infection -- Introduction -- Community-Acquired ABM -- Epidemiology -- Clinical features and appropriate investigations -- Pathophysiology of ABM -- Treatment -- Encephalitis -- Specific definition and epidemiology -- Clinical features and appropriate investigations -- HSV and VZV encephalitis -- Encephalitides in patients who are immunocompromised -- Community-Acquired brain abscess -- Epidemiology and microbiology -- Pathogenesis -- Neuroimaging -- Diagnostic approach to brain abscess -- Anti-Infective therapy -- Neurosurgery -- Conclusions.

References -- Chapter 5 Herpes Simplex Virus Infections of the CNS -- Definition -- Definition of the disorder, major synonyms, and historical perspective -- Microbiological characteristics -- Epidemiology: incidence and prevalence, sex, age, geographical distribution, and risk factors -- Infection in children and adults -- Neonatal infection -- Infection in adults and children -- Primary infection -- Classic HSVE -- Atypical HSVE -- Granulomatous herpes simplex encephalitis -- Spinal cord disease associated with hsv infection -- Aseptic meningitis -- Neonatal HSVE -- Etiology -- Clinical features -- Neuropathology -- Genetics and pathogenesis -- Treatment, future perspective, and conclusions -- References -- Chapter 6 Varicella-Zoster Virus and Epstein-Barr Virus Infections of the CNS -- Definition -- Infection of the CNS by varicella-zoster virus -- Definition, major synonyms, and microbiological characteristics -- Epidemiology -- Clinical features of the neurological complications of VZV infection -- Neuropathology -- Pathogenesis -- Neonatal varicella -- Treatment and future perspective -- Infection of the CNS by Epstein-Barr virus -- Definition, epidemiology, microbiological characteristics, and genetics -- Clinical features -- Neuropathology -- Treatment -- References -- Chapter 7 Cytomegalovirus Infections of the CNS -- Definition of the disorder, major synonyms, and historical perspective -- Epidemiology: incidence and prevalence, sex, age, geographical distribution, and risk factors -- Microbiological characteristics -- Clinical features including appropriate investigations -- Clinical manifestations -- Imaging studies -- Laboratory tests -- Pathology -- CMV infection of the CNS in adults and children -- Congenital CMV infection -- Pathogenesis -- Animal models -- Treatment, future perspective, and conclusions -- References.

Chapter 8 Adenovirus Meningoencephalitis -- Introduction -- Epidemiology -- Clinical and neuroimaging features -- Diagnostic considerations -- Neuropathology -- Pathogenesis and animal models -- Treatment and future directions -- Acknowledgments -- References -- Chapter 9 Polyomavirus Infections of the CNS -- CNS disorders caused by polyomaviridae: history and syndromes -- Microbiological and genetic characteristics of polyomaviridae -- Epidemiology, risk factors -- Clinical features and diagnosis -- Neuropathology -- PML -- JCV-Associated gray matter pathologies -- JCV-Associated inflammatory pathologies -- BKV-Associated pathologies -- Molecular biology and pathogenesis -- Animal models -- Treatments and future perspectives -- References -- Chapter 10 Measles Virus Infection of the CNS -- Introduction -- Microbiological characteristics of MV -- Epidemiology and genetics -- Subacute sclerosing panencephalitis -- Definition of the disorder, major synonyms, and historical perspective -- Epidemiology -- Pathogenesis and genetics -- Clinical presentation -- Neuropathology -- Measles inclusion body encephalitis -- Definition of the disorder and major synonyms -- Epidemiology -- Pathogenesis -- Clinical features -- Neuropathology -- Animal models -- Treatment -- References -- Chapter 11 Rubella Virus -- Definition of the disorder, major synonyms, and historical perspective -- Microbiological characteristics -- Epidemiology: incidence and prevalence, sex, age, geographical distribution, and risk factors -- Clinical features -- Major symptoms -- Laboratory testing -- Pathology -- Genetic and pathogenesis -- Treatment, future perspective, and conclusions -- References -- Chapter 12 Henipavirus Encephalitis -- Definition of the disorders, major synonyms, and historical perspective -- Microbiological characteristics.

Epidemiology: Incidence and prevalence, sex, age, geographical distribution, and risk factors -- Clinical features -- Pathology of human henipavirus infection -- Animal models and pathogenesis -- Treatment, future perspective, and conclusions -- References -- Chapter 13 Rabies -- Introduction, microbiological characteristics, and historical perspective -- Epidemiology -- Pathogenesis -- In humans -- Animal models -- Clinical features and diagnosis -- Clinical diagnosis -- Laboratory diagnosis -- Pathology, including histopathology and immunocytochemistry -- Treatment and future perspective -- Conclusion -- References -- Chapter 14 Flaviviruses 1: General Introduction and Tick‐Borne Encephalitis -- Flaviviruses: general introduction -- Significance, classification, and historical perspective -- Genetics and microbiological characteristics of FVs -- Epidemiology -- Clinical features -- Pathology -- Animal models and pathogenesis -- Treatment and prophylaxis -- TBE -- Significance, definition, and historical perspective -- Genetics and microbiological characteristics -- Epidemiology -- Clinical features -- Pathology -- Pathogenesis -- Animal models and pathogenesis -- Treatment, prevention, and conclusions -- References -- Chapter 15 Flaviviruses 2: West Nile, St. Louis Encephalitis, Murray Valley Encephalitis, Yellow Fever, and Dengue -- Introduction -- Epidemiology -- Geographic distribution -- Burden of human disease -- Vectors and hosts -- Risk factors and genetics -- Clinical features -- Shared symptoms and signs -- Disease-specific symptoms and signs -- Neuro-imaging -- Laboratory findings -- Pathology -- WNND -- St. Louis encephalitis -- Murray valley encephalitis -- Yellow fever -- Dengue -- Pathogenesis -- Common pathogenic principles -- WNV, SLEV, and MVEV neuropathogenesis -- Yellow fever -- Dengue -- Animal models -- Treatment and vaccines.

Treatment -- Vaccines -- Acknowledgments -- References -- Chapter 16 Flaviviruses 3: Zika Virus Infection of the CNS -- Definition of the disorder and historical perspective -- Clinical features, including appropriate investigations -- Pathology -- Macroscopic findings -- Histopathological findings -- Genetics and pathogenesis -- Treatment, future perspective, and conclusions -- References -- Chapter 17 Flaviviruses 4: Japanese Encephalitis -- Definition of the disorder, major synonyms, and historical perspective -- Microbiological characteristics -- Epidemiology -- Clinical features -- Pathology -- Pathogenesis and animal models -- Treatment, future perspective, and conclusions -- References -- Chapter 18 CNS Disorders Caused by Hepatitis C and Hepatitis E Viruses -- Definition of the disorder, major synonyms, and historical perspective -- Microbiology -- Epidemiology -- Clinical features -- Pathology -- Pathogenesis -- Animal models -- Treatment -- References -- Chapter 19 Alphaviral Equine Encephalomyelitis (Eastern, Western, and Venezuelan) -- Definition of the disorder, major synonyms, and historical perspective -- Microbiological characteristics -- Epidemiology -- Clinical features -- Pathology -- Genetics and pathogenesis -- Animal models and pathogenesis -- Treatment, future perspective, and conclusions -- References -- Chapter 20 Chikungunya Virus -- Introduction -- Virology and pathophysiology -- Clinical features -- Systemic presentation -- Involvement of the CNS -- Diagnosis -- Pathology -- Treatment and future perspectives -- References -- Chapter 21 Poliovirus Infection and Postpolio Syndrome -- Poliomyelitis and polioencephalitis virus infection -- Definition of the disorder, major synonyms, and historical perspective -- Microbiology and genetics -- Epidemiology -- Clinical features, diagnosis, cerebrospinal fluid, and differentials.

Pathology histopathology, electron microscopy, and immunocytochemistry.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.