Motor Neuron Diseases : Causes, Classification and Treatments.

Intro -- MOTOR NEURON DISEASES: CAUSES, CLASSIFICATION AND TREATMENTS -- MOTOR NEURON DISEASES: CAUSES, CLASSIFICATION AND TREATMENTS -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter I: MOTOR NEURON DISEASE: CAUSES, CLASSIFICATION AND TREATMENTS -- ABSTRACT -- 1.1. INTRODUCTION -- 1.2. IMPACT OF MND -- 1.3. EPIDEMIOLOGY AND RISK FACTORS -- 1.4. AETIOLOGY AND PATHOGENESIS -- 1.5. CLASSIFICATION -- 1.6. DIAGNOSIS -- 1.7. MEASUREMENT TOOLS -- 1.8. PHARMACOLOGICAL MANAGEMENT -- 1.9. MULTIDISCIPLINARY CARE -- 1.10. MULTIDISCIPLINARY CARE ISSUES IN MND -- CONCLUSION -- REFERENCES -- Chapter II: MEMBRANE TRAFFICKING DEFECTS AS DETERMINANTS OF MOTOR NEURON SUSCEPTIBILITY AND DEGENERATION IN ALS -- ABSTRACT -- INTRODUCTION -- 1. AXONAL TRANSPORT -- 2. ENDOPLASMIC RETICULUM AND GOLGI APPARATUS TRANSPORT -- 3. ENDOSOME-LYSOSOME TRANSPORT -- 4. NUCLEAR TRANSPORT -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter III: MOTONEURON SPECIFIC CALCIUM DYSREGULATION AND PERTURBED CELLULAR CALCIUM HOMESTASIS IN AMYOTROPHIC LATERAL SCLEROSIS: RECENT ADVANCES GAINED FROM GENETICALLY MODIFIED ANIMALS AND CELL CULTURE MODELS -- ABSTRACT -- ABBREVIATIONS -- INTRODUCTION -- DISEASE MECHANISM IN AMYOTROPHIC LATERAL SCLEROSIS -- DISRUPTED CALCIUM HOMEOSTASIS IN AMYOTROPHIC LATERAL SCLEROSIS -- OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION -- GLUTAMATE TRANSMISSION AND EXCITOTOXICITY -- MISFOLDED PROTEIN STRESS -- CYTOSKELETAL DISORGANISATION AND NEUROFILAMENT DEFECTS -- ABNORMALITIES IN INTRACELLULAR AXONAL TRANSPORT -- MECHANISM UNDERLYING MITOCHONDRIA-ER CA2+ STORES COUPLING -- ROLE OF CROSS-TALK BETWEEN MOTONEURONS AND GLIA IN ALS VULNERABILITY AND PATHOGENESIS -- CHARACTERISTICALLY LOW CA2+ BUFFERING CAPACITY OF MOTONEURONS AND ITS IMPACT ON SELECTIVE MOTONEURON VULNERABILITY.

MITOCHONDRIAL DYSFUNCTION, CA2+ HOMEOSTASIS AND ALS: A MULTIFACTORIAL DISEASE MECHANISM -- DRUG TARGETS AND MULTIDRUG THERAPIES IN ALS: WHERE SHOULD WE AIM? -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter IV: TREATMENT OF ALS UTILIZING A STEM CELL STRATEGY -- ABSTRACT -- GENERAL INTRODUCTION OF ALS -- STEM CELLS AND THEIR APPLICATION IN ALS TREATMENT -- STEM CELLS AND THEIR APPLICATION IN ALS TREATMENT -- CELL REPLACEMENT STRATEGY VS. TROPHIC SUPPORT STRATEGY -- CHALLENGES FOR STEM CELL THERAPY -- CONCLUSION -- REFERENCES -- Chapter V: TDP-43-IMMUNOREACTIVE PATHOLOGY IN FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP PROTEINOPATHY (FTLD-TDP) WITH AND WITHOUT ASSOCIATED MOTOR NEURON DISEASE (MND) -- ABSTRACT -- INTRODUCTION -- MATERIALS AND METHODS -- DENSITIES OF PATHOLOGICAL FEATURES IN FTLD-MND -- PCA OF THE FTLD-MND CASES BASED ON ALL HISTOLOGICAL FEATURES (PCA-1) -- COMPARISON OF FTLD-MND WITH FAMILIAL AND SPORADIC CASES OF FTLD-TDP -- PCA OF ALL FTLD-TDP CASES BASED ON TDP-43-IMMUNOREACTIVE INCLUSIONS (PCA-2) -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter VI: EXCITOTOXICITY AND SELECTIVE MOTOR NEURON DEGENERATION -- ABSTRACT -- INTRODUCTION -- THE INITIAL CULPRIT: GLUTAMATE AND OTHER EXCITOTOXINS -- THE ACCOMPLICE: AMPA RECEPTORS -- THE CLEANERS: GLUTAMATE TRANSPORTERS -- THE VICTIM: MOTOR NEURONS -- CONCLUSION -- REFERENCES -- Chapter VII: STEM CELL APPLICATION IN AMYOTROPHIC LATERAL SCLEROSIS: GROWTH FACTOR DELIVERY AND CELL THERAPY -- ABSTRACT -- INTRODUCTION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter VIII: THERAPEUTIC INTERVENTION IN SPINAL AND BULBAR MUSCULAR ATROPHY (SBMA) -- ABSTRACT -- INTRODUCTION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter IX: EXPERT COMMENTARY:MOTOR NEURON DISEASE: ASSISTIVE TECHNOLOGY -- INTRODUCTION -- ASSISTIVE TECHNOLOGY FOR MOBILITY.

ASSISTIVE TECHNOLOGY FOR COMMUNICATION AND COMPUTER ACCESS -- ENVIRONMENTAL CONTROL UNITS -- REFERENCES -- Chapter X: COMPARATIVE STUDY ON APPLICATION OF INVASIVE AND NON-INVASIVE VENTILATION TO ALS PATIENTS IN JAPAN, THE USA AND EUROPE -- ABSTRACT -- I. INTRODUCTION -- II. THE EFFICACY OF TV AND NIV ON ALS PATIENTS -- III. THE PREVALENCE OF TV AND NIV ON ALS PATIENTS -- V. CAREGIVER'S DEPRESSION -- VI. THE TOTALLY LOCKED-IN STATE (TLS) -- VII. DISCUSSION -- VIII. CONCLUSIONS -- ACKNOWLEDGMENTS -- CONFLICT OF INTEREST STATEMENT -- REFERENCES -- Chapter XI: MOTOR SPEECH DISORDER IN PATIENTS WITH MOTOR NEURON DISEASE: HOW TO ESTIMATE AND MANAGE THEIR DISTURBED SPEECHSOUNDS CLINICALLY -- INTRODUCTION -- CLINICAL FEATURES OF DYSARTHRIA OF THE PATIENT WITH MND -- EXAMINATIONS FOR THE VELOPHARYNGAEL FUNCTION AND THE MANAGEMENTS FOR VELOPHARYNGEAL INADEQUACY -- EXAMINATION OF THE TONGUE MOVEMENT AND THE MANAGEMENT FOR THE DISTURBED TONGUE MOVEMENT DURING SPEECH -- EXAMINATION OF RESPIRATORY FUNCTION TO PRODUCE THE PHONATORY SOUND AND THE MANAGEMENT THE AFFECTED MUSCLE STRENGTH OF THE MUSCLES FOR RESPIRATIONS -- FUTURE FOR DYSARTHRIA OF THE PATIENT WITH MND -- REFERENCES -- INDEX.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.