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Fundamentals of MALDI-ToF-MS Analysis : Applications in Bio-Diagnosis, Tissue Engineering and Drug Delivery.

By: Contributor(s): Material type: TextTextSeries: SpringerBriefs in Applied Sciences and Technology SeriesPublisher: Singapore : Springer Singapore Pte. Limited, 2016Copyright date: ©2017Edition: 1st edDescription: 1 online resource (76 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9789811023569
Subject(s): Genre/Form: Additional physical formats: Print version:: Fundamentals of MALDI-ToF-MS AnalysisDDC classification:
  • 543.65
LOC classification:
  • R856-857
Online resources:
Contents:
Intro -- Preface -- Acknowledgment -- Contents -- 1 Principles and Mechanism of MALDI-ToF-MS Analysis -- Abstract -- 1.1 Background of MALDI-ToF-MS -- 1.2 Applications of MALDI-ToF-MS -- 1.2.1 Biochemistry -- 1.2.2 Organic Chemistry -- 1.2.3 Polymer Chemistry -- 1.2.4 Microbiology -- 1.2.5 Medicine -- 1.2.6 Nanotechnology -- 1.3 Ionization Mechanism -- 1.4 Time of Flight Mass Spectrometry Mechanism -- 1.5 Detection Modes -- 1.5.1 Linear Mode -- 1.5.2 Reflection Mode -- 1.6 Laser Range in MALDI -- 1.7 Matrix Selection -- 1.7.1 Limitations of Matrices -- 1.8 Ionizing Agent Selection -- 1.9 Fundamentals of Sample Preparation for MALDI Analysis -- 1.9.1 Analyzable and Non-analyzable Polymers -- 1.9.2 Sample Preparation Techniques -- 1.9.2.1 Dried-Droplet -- 1.9.2.2 Fast Crystallization -- 1.9.2.3 Spin Coating -- 1.9.2.4 Layer by Layer -- 1.9.2.5 Electrospray Deposition -- 1.10 Mass Discrimination -- 1.10.1 Alternative Solutions for Overcoming Mass Discrimination -- 1.11 MALDI Coupling -- 1.11.1 Ion-Mobility Time of Flight Mass Spectrometry (IMS-ToF-MS) -- 1.11.2 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) -- 1.11.3 Thin Layer Chromatography (TLC) -- 1.11.4 Size Exclusion Chromatograph (SEC) -- References -- 2 Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic Domain -- Abstract -- 2.1 Biosensors -- 2.2 Synthesis of Poly Methyl Methacrylate-Co-Methacrylic Acid P(MMA-Co-MAA) and Preparation of the Biochips -- 2.3 Sample Preparation for MALDI Analysis -- 2.4 MALDI Data Interpretation -- 2.4.1 Different Species as the Possible Products of Soft Ionization -- 2.4.2 General Structure of P(MMA-Co-MAA) -- 2.4.3 MALDI Analysis of PMMA -- 2.4.4 MALDI Analysis of P(MMA-Co-MAA) -- 2.4.5 End-Group Analysis -- 2.5 Role of MALDI Analysis in Bio-sensing Application of P(MMA-Co-MAA) -- 2.5.1 Reaction's Parameters.
2.5.2 Chemistry Aspect -- 2.5.3 Physical Aspect -- References -- 3 Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials -- Abstract -- 3.1 Tissue Engineering -- 3.2 Synthesis of Poly Octanediol Citrate Acid-Sebacate Acid P(OCS) and Preparation of the Scaffold -- 3.3 MALDI Analysis of P(OCS) and Sample Preparation -- 3.4 MALDI Data Interpretation -- 3.5 Role of MALDI Analysis in Tissue Engineering Application of P(OCS) -- 3.5.1 Reaction's Parameters -- 3.5.2 Chemistry Aspect -- 3.5.3 Mechanical Aspect -- References -- 4 Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug Delivery -- Abstract -- 4.1 Drug Delivery -- 4.2 Synthesis of PCLT-CA and Preparation of Elastomeric Films and Coatings -- 4.3 Sample Preparation for MALDI Analysis -- 4.4 MALDI Data Interpretation -- 4.5 The Role of MALDI Analysis in Drug Delivery Application of PCLT-CA -- 4.5.1 Chemistry Aspect -- 4.5.2 Mechanical Aspect -- References -- Summary.
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Intro -- Preface -- Acknowledgment -- Contents -- 1 Principles and Mechanism of MALDI-ToF-MS Analysis -- Abstract -- 1.1 Background of MALDI-ToF-MS -- 1.2 Applications of MALDI-ToF-MS -- 1.2.1 Biochemistry -- 1.2.2 Organic Chemistry -- 1.2.3 Polymer Chemistry -- 1.2.4 Microbiology -- 1.2.5 Medicine -- 1.2.6 Nanotechnology -- 1.3 Ionization Mechanism -- 1.4 Time of Flight Mass Spectrometry Mechanism -- 1.5 Detection Modes -- 1.5.1 Linear Mode -- 1.5.2 Reflection Mode -- 1.6 Laser Range in MALDI -- 1.7 Matrix Selection -- 1.7.1 Limitations of Matrices -- 1.8 Ionizing Agent Selection -- 1.9 Fundamentals of Sample Preparation for MALDI Analysis -- 1.9.1 Analyzable and Non-analyzable Polymers -- 1.9.2 Sample Preparation Techniques -- 1.9.2.1 Dried-Droplet -- 1.9.2.2 Fast Crystallization -- 1.9.2.3 Spin Coating -- 1.9.2.4 Layer by Layer -- 1.9.2.5 Electrospray Deposition -- 1.10 Mass Discrimination -- 1.10.1 Alternative Solutions for Overcoming Mass Discrimination -- 1.11 MALDI Coupling -- 1.11.1 Ion-Mobility Time of Flight Mass Spectrometry (IMS-ToF-MS) -- 1.11.2 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) -- 1.11.3 Thin Layer Chromatography (TLC) -- 1.11.4 Size Exclusion Chromatograph (SEC) -- References -- 2 Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic Domain -- Abstract -- 2.1 Biosensors -- 2.2 Synthesis of Poly Methyl Methacrylate-Co-Methacrylic Acid P(MMA-Co-MAA) and Preparation of the Biochips -- 2.3 Sample Preparation for MALDI Analysis -- 2.4 MALDI Data Interpretation -- 2.4.1 Different Species as the Possible Products of Soft Ionization -- 2.4.2 General Structure of P(MMA-Co-MAA) -- 2.4.3 MALDI Analysis of PMMA -- 2.4.4 MALDI Analysis of P(MMA-Co-MAA) -- 2.4.5 End-Group Analysis -- 2.5 Role of MALDI Analysis in Bio-sensing Application of P(MMA-Co-MAA) -- 2.5.1 Reaction's Parameters.

2.5.2 Chemistry Aspect -- 2.5.3 Physical Aspect -- References -- 3 Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials -- Abstract -- 3.1 Tissue Engineering -- 3.2 Synthesis of Poly Octanediol Citrate Acid-Sebacate Acid P(OCS) and Preparation of the Scaffold -- 3.3 MALDI Analysis of P(OCS) and Sample Preparation -- 3.4 MALDI Data Interpretation -- 3.5 Role of MALDI Analysis in Tissue Engineering Application of P(OCS) -- 3.5.1 Reaction's Parameters -- 3.5.2 Chemistry Aspect -- 3.5.3 Mechanical Aspect -- References -- 4 Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug Delivery -- Abstract -- 4.1 Drug Delivery -- 4.2 Synthesis of PCLT-CA and Preparation of Elastomeric Films and Coatings -- 4.3 Sample Preparation for MALDI Analysis -- 4.4 MALDI Data Interpretation -- 4.5 The Role of MALDI Analysis in Drug Delivery Application of PCLT-CA -- 4.5.1 Chemistry Aspect -- 4.5.2 Mechanical Aspect -- References -- Summary.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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