Arboviruses : Molecular Biology, Evolution and Control.

Intro -- Contents -- Contributors -- Foreword -- Current Books of Interest -- Preface -- 1: The Arboviruses: Quo Vadis? -- Introduction -- Current status of arboviral diseases -- Reasons for global emergence -- Part I: Molecular Biology -- 2: The Taxonomy of Arboviruses -- Introduction -- Virus taxonomy -- Taxonomy: from classical virology to molecular biology -- A taxonomic ideal -- Arbovirus taxonomy -- Conclusions -- Appendix 2.1 Taxonomy of arbovirusesa,b -- Appendix 2.2 Taxonomy of arthropod virusesa -- 3: Genomic Organization of Arboviral Families -- Introduction -- Alphaviruses -- Flaviviruses -- Rhabdoviruses -- Bunyaviruses -- Reoviruses -- Orthomyxoviruses -- 4: Host Metabolism and its Contribution in Flavivirus Biogenesis -- Introduction -- The players -- The membranes -- The master metabolic switches -- Conclusions and perspectives -- 5: Vector-borne Bunyavirus Pathogenesis and Innate Immune Evasion -- Introduction -- Transmission -- Pathogenesis -- Genome -- Innate immunity -- Cellular death and apoptosis -- 6: Vector-borne Rhabdoviruses -- Introduction: general characteristics of rhabdoviruses -- Replication cycle -- Virus-host interactions -- Other rhabdoviruses with established or inferred vector transmission -- 7: Alphavirus-Host Interactions -- Alphaviruses of medical importance -- Alphavirus molecular biology related to host interaction -- Cellular detection of and response to alphavirus infection -- Antagonism of host gene expression in infected cells -- IFN-inducible and other antiviral effectors -- Host-alphavirus interactions in pathogenesis -- Future perspectives -- 8: Molecular Interactions Between Arboviruses and Insect Vectors: Insects' Immune Responses to Virus Infection -- Introduction -- Molecular biology of the arbovirus-insect interaction.

Beyond insects and arboviruses: the impact of symbionts and the microbiome on arbovirus vectorial capacity -- Conclusion -- Part II: Viral Diversity and Evolution -- 9: Genetic Diversity of Arboviruses -- Introduction -- Diversity in genome structure and organization between and within viral families -- Molecular mechanisms responsible for genetic diversity -- Heterogeneity of genome size and protein repertoire within viral families -- Genetic diversity and the host: influence of the invertebrate vector and pathogenesis in the vertebrate host -- Genetic diversity and geographic distribution: compounding effects of host, climate and globalization? -- Concluding remarks and future directions -- 10: Ecological and Epidemiological Factors Influencing Arbovirus Diversity, Evolution and Spread -- Introduction -- Arbovirus transmission cycles and persistence -- Arbovirus spread and establishment -- The effect of climate change on arboviruses -- Genetic factors underlying diversity and spread -- Emergence of insect-specific viruses and their effect on arboviral transmission -- Newly found arboviruses of humans and animals -- Protocols to detect, discover and monitor newly emerged arboviruses -- Conclusions -- 11: Role of Inter- and Intra-host Genetics in Arbovirus Evolution -- Significance of genetic change in arboviruses -- Relationship between within and between-host mutational diversity -- Arboviral plasticity and robustness -- Multihost adaptation and host range expansion -- Next generation studies of the relationship between mutational diversity and phenotype -- Summary and future studies -- 12: Arbovirus Genomics and Metagenomics -- Introduction -- Approaches to whole genome sequencing -- Wet-lab techniques for preparation of samples for sequencing -- Bioinformatics protocols for second generation sequencing platforms -- Conclusion -- Future trends.

13: Role of Vertical Transmission in Mosquito-borne Arbovirus Maintenance and Evolution -- Introduction -- Evidence for vertical transmission of arboviruses -- La Crosse virus and Ae. triseriatus: a most remarkable relationship -- Summary -- 14: The Boundaries of Arboviruses: Complexities Revealed in Their Host Ranges, Virus-Host Interactions and Evolutionary Relationships -- Introduction -- Arthropod association with viruses -- Arthropod associations with plant viruses -- Vertebrate associations with viruses -- A list of selected reports presenting ambiguous or intriguing data regarding the boundaries between arboviruses and non-arboviruses -- Virological attributes of selected environments and hosts -- Persistent infection and pathology of viral infection -- Phylogeny and empirical data in support of phylogenetic tree topology -- Genetic determinants of host range among arboviruses -- Other issues concerning host range -- Re-examination of the tenets of arboviruses -- Expanding scope of research on invertebrate-associated viruses -- Part III: Arbovirus Diagnosis and Control -- 15: Laboratory Diagnosis of Arboviruses -- Overview -- Serology -- Direct detection -- A recommendation for cautious use of point-of-care tests for arboviral diagnosis -- 16: Conventional Vector Control: Evidence it Controls Arboviruses -- Introduction -- Evidence that mosquito control prevents transmission of epizootic arboviruses -- Dengue -- 17: Biological Control of Arbovirus Vectors -- Introduction -- Predators -- Pathogens -- Symbionts -- Summary and future prospects -- 18: RNA Interference: a Pathway to Arbovirus Control -- Introduction -- Use of exogenous small RNAs to treat arbovirus infection -- Blocking arbovirus transmission with small RNAs -- Attenuating arboviruses using small RNAs -- Challenges, gaps and future research directions.

19: Genetically Modified Vectors for Control of Arboviruses -- Introduction -- Aedes aegypti -- Vector competence and vectorial capacity -- Aedes aegypti control -- Genetically modified vectors for arbovirus control -- GMVs for control strategies aimed at vector population reduction -- GMVs for vector population replacement to control arbovirus transmission -- Regulatory considerations for using GMVs to control arbovirus transmission -- 20: Arbovirus Vaccines -- Introduction -- Bunyaviridae -- Flaviviridae -- Reoviridae -- Togaviridae -- 21: Small Molecule Drug Development for Dengue Virus -- Introduction -- Developmental stages of antivirals -- Rationale and target product profile -- Discovery of inhibitors of dengue virus -- Classic targets for DAA development -- Conclusions and challenges -- Part V: Future Trends -- 22: Arbovirology: Back to the Future -- The very early days of viral disease diagnosis -- Virus identification and serological methods -- Research into clinical aspects of virus diseases -- Virus taxonomy -- Field studies of viruses -- Suggestions for restoring balance to arbovirology and other fields of virus research -- Index.

This book brings together a panel of expert arbovirologists to produce a timely review of the rapidly expanding arbovirus research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: taxonomy, genome organization, virus-host and virus-vector interactions, evolutionary history, role of vertical transmission in arbovirus maintenance and evolution, epidemiology, arbovirus replication, pathogenesis, arbovirus diagnostics and control, including vaccines, novel anti-viral drugs, RNA interference and genetically modified vectors. Essential reading for every arbovirologist and highly recommended for all virologists and public health officials.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.