Handbook on the Toxicology of Metals.

e9780444594532v1 -- Front Cover -- Handbook on theToxicology of Metals -- Copyright -- Preface -- Short Contents -- Full Contents -- List of Contributors -- List of Reviewers -- Volume I - General Considerations -- Chapter 1 - Toxicology of Metals: Overview, Definitions, Concepts, and Trends -- 1 METAL EXPOSURES AND GLOBAL BURDEN OF DISEASE -- 2 INTERNATIONAL HISTORICAL PERSPECTIVES ON RISKS OF HEALTH EFFECTS OF METALS -- 3 METAL POISONING AND OTHER HUMAN HEALTH EFFECTS -- 4 HUMAN EXPOSURES TO METALLIC COMPOUNDS, RISK ASSESSMENT, AND PREVENTION -- References -- Chapter 2 - General Chemistry, Sampling, Analytical Methods, and Speciation* -- 1 DEFINITION OF METALS -- 2 THE PERIODIC TABLE -- 3 COMPOUNDS OF METALLIC ELEMENTS -- 4 SOLUBILITY -- 5 PROPERTIES OF METAL IONS -- 6 OTHER ASPECTS OF METAL CHEMISTRY OF BIOLOGICAL AND TOXICOLOGICAL INTEREST -- 7 METALLOMICS, TOTAL ELEMENT ANALYSIS, AND ELEMENTAL SPECIATION -- 8 SAMPLING AND SAMPLE PREPARATION -- 9 SEPARATION TECHNIQUES -- 10 DETECTION METHODS -- 11 CALIBRATION -- 12 REFERENCE MATERIALS -- 13 QUALITY ASSURANCE -- 14 CONCLUSIONS -- References -- Chapter 3 - Routes of Exposure, Dose, and Toxicokinetics of Metals* -- 1 INTRODUCTION -- 2 EXPOSURE -- 3 DEPOSITION AND ABSORPTION -- 4 TRANSPORT, BIOTRANSFORMATION, AND DISTRIBUTION -- 5 PATHWAYS AND MECHANISMS OF EXCRETION -- 6 TOXICOKINETIC MODELS AND THEIR USE IN ESTABLISHING DOSE-RESPONSE AND DOSE-EFFECT RELATIONSHIPS -- 7 USE OF INDICATOR MEDIA FOR ESTIMATING EXPOSURE OR CRITICAL ORGAN CONCENTRATION -- References -- Chapter 4 - Toxicity of Metal and Metal Oxide Nanoparticles -- 1 METAL AND METAL OXIDE NANOPARTICLES -- 2 PRINCIPLES OF NANOPARTICLE-INDUCED TOXICITY -- 3 PHYSICOCHEMICAL CHARACTERIZATION -- 4 METHODS FOR TOXICITY TESTING OF NANOPARTICLES -- 5 GOLD NANOPARTICLES -- 6 SILVER NANOPARTICLES -- 7 PLATINUM AND PALLADIUM NANOPARTICLES.

8 ALUMINUM AND ALUMINUM OXIDE NANOPARTICLES -- 9 COPPER AND COPPER OXIDE NANOPARTICLES -- 10 NICKEL AND NICKEL OXIDE NANOPARTICLES -- 11 IRON OXIDE NANOPARTICLES -- 12 TITANIUM DIOXIDE NANOPARTICLES -- 13 ZINC OXIDE NANOPARTICLES -- 14 CERIUM OXIDE NANOPARTICLES -- 15 SILICON DIOXIDE OR SILICA NANOPARTICLES -- 16 SEMICONDUCTOR NANOCRYSTALS -- 17 CONCLUDING REMARKS -- References -- Chapter 5 - Toxicity of Metals Released from Implanted Medical Devices -- 1 BACKGROUND -- 2 TOXICOLOGICAL ISSUES ASSOCIATED WITH METAL RELEASE FROM SPECIFIC TYPES OF IMPLANTED MEDICAL DEVICES -- 3 CHALLENGES AND FUTURE DIRECTIONS -- References -- Chapter 6 - Toxic Metals in Food -- 1 INTRODUCTION -- 2 CADMIUM -- 3 LEAD -- 4 MERCURY -- 5 ARSENIC -- 6 HEALTH-BASED GUIDANCE VALUES AND BENCHMARK DOSE (LOWER CONFIDENCE LIMIT) FOR CADMIUM, MERCURY, LEAD, AND ARSENIC -- 7 FOOD CONTAMINATION FROM PACKAGING -- 8 CONCLUSION -- References -- Chapter 7 - Exposure Assessment, Forward and Reverse Dosimetry* -- 1 INTRODUCTION -- 2 GENERAL PRINCIPLES -- 3 PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING -- 4 BIOMONITORING AND ITS INTERPRETATION -- 5 HUMAN PBPK TOOL KIT DEVELOPMENT: THE GENERAL APPROACH -- 6 CONCLUSIONS -- References -- Chapter 8 - Biological Monitoring and Biomarkers -- 1 INTRODUCTION -- 2 SOURCES OF PREANALYTICAL AND ANALYTICAL ERROR -- 3 QUALITY ASSURANCE: REFERENCE MATERIALS -- 4 SPECIMENS IN USE -- 5 REFERENCE VALUES AND BIOMONITORING GUIDANCE VALUES -- 6 BIOMARKERS OF EXPOSURE -- 7 BIOMARKERS OF EFFECTS -- 8 ETHICAL CONSIDERATIONS -- 9 BIOMONITORING IN HEALTH RISK ASSESSMENT AND MANAGEMENT -- 10 FUTURE TRENDS -- References -- Chapter 9 - Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity -- 1 TRANSPORT OF TOXIC METALS BY MOLECULAR/IONIC MIMICRY OF ESSENTIAL COMPOUNDS -- 2 INTERFERENCE WITH THE FUNCTIONS OF ESSENTIAL METALS BY TOXIC METALS.

3 TOXIC METAL-BINDING MOLECULES -- 4 MUTAGENIC AND GENOTOXIC EFFECTS OF METALS -- 5 EPIGENETIC EFFECTS OF METAL COMPOUNDS -- 6 EFFECTS OF METALS ON CELL SIGNALING PATHWAYS AND GENE EXPRESSION -- References -- CHAPTER 10 - General Considerations of Dose-Effect and Dose-Response Relationships* -- 1 GENERAL ASPECTS OF DOSE-RESPONSE RELATIONSHIPS -- 2 MODELING OF DOSE-RESPONSE RELATIONSHIPS -- 3 MODELING THE DATA -- 4 SPECIES-TO-SPECIES EXTRAPOLATIONS -- 5 RISK ASSESSMENT AND DOSE-RESPONSE RELATIONSHIPS -- 6 DOSE RESPONSE IN AN ERA OF "OMICS" -- References -- Chapter 11 - Interactions and Mixtures in Metal Toxicology -- 1 INTRODUCTION AND GENERAL CONSIDERATIONS -- 2 AGE, GENDER, DRUGS, AND OTHER FACTORS -- 3 JOINT METAL-METAL ACTIONS (NONCARCINOGENIC EFFECTS) -- 4 JOINT METAL ACTIONS IN CARCINOGENESIS -- 5 RISK ASSESSMENT OF MIXTURES OF METALS -- 6 Perspectives and Future Needs -- References -- Chapter 12 - Gene-Environment Interactions for Metals -- 1 GENE-ENVIRONMENT INTERACTIONS FOR METALS -- 2 INTERACTIONS OF SPECIFIC METALS -- 3 CONCLUSIONS -- References -- Chapter 13 - Epidemiological Approaches to Metal Toxicology -- 1 INTRODUCTION -- 2 EPIDEMIOLOGICAL TERMS -- 3 STUDY DESIGN -- 4 STUDY POPULATION -- 5 EXPOSURE ASSESSMENT -- 6 ASSESSMENT OF EFFECTS -- 7 DATA ANALYSIS AND ASSESSMENT OF THE BENCHMARK DOSE -- 8 INFERENCE -- References -- CHAPTER 14 - ESSENTIAL METALS: ASSESSING RISKS FROM DEFICIENCY AND TOXICITY FN1* -- 2 BASIC CONCEPTS -- 3 EFFECTS OF DEFICIENCY AND TOXICITY -- 4 SUMMARY OF THE PRINCIPLES OF HUMAN RISK ASSESSMENT FOR EXPOSURES TO ESSENTIAL METALS -- 5 ESTIMATION OF THE AROI -- 6 CONCLUSIONS AND RECOMMENDATIONS -- References -- Chapter 15 - Neurotoxicology of Metals -- 1 FROM NEUROPHYSIOLOGY TO NEUROTOXICOLOGY -- 2 CENTRAL NERVOUS SYSTEM DEVELOPMENT AND WINDOWS OF VULNERABILITY -- 3 MECHANISTIC BASES OF METAL NEUROTOXICITY.

References -- Chapter 16 - Cardiovascular Disease -- 1 INTRODUCTION -- 2 ALUMINUM -- 3 ARSENIC -- 4 BERYLLIUM -- 5 CADMIUM -- 6 CHROMIUM -- 7 COBALT -- 8 IRON -- 9 LEAD -- 10 MAGNESIUM -- 11 MANGANESE -- 12 MERCURY -- 13 NICKEL -- 14 SELENIUM -- 15 URANIUM -- 16 ZINC -- 17 CONCLUDING REMARKS -- References -- Chapter 17 - Renal Effects of Exposure to Metals -- 1 INTRODUCTION -- 2 FUNCTION OF THE KIDNEYS AND INDICATORS OF INJURY -- 3 RENAL EFFECTS OF EXPOSURE TO METALS -- References -- CHAPTER 18 - CARCINOGENICITY OF METAL COMPOUNDS* -- 2 POTENTIAL MECHANISMS OF METAL CARCINOGENESIS -- 3 EPIGENETIC EFFECTS OF METALS -- References -- Chapter 19 - Immunotoxicology of Metals -- 1 INTRODUCTION -- 2 IMMUNOSUPPRESSION INDUCED BY METALS -- 3 NUTRITIONALLY ESSENTIAL METALS AND THE IMMUNE SYSTEM -- 4 HYPERSENSITIVITY INDUCED BY METALS -- 5 METALS CAUSING HYPERSENSITIVITY REACTIONS -- 6 INTERACTION BETWEEN METALS AND PROTEINS -- 7 OTHER INTERACTIONS BETWEEN METALS AND PROTEINS: IMPLICATIONS FOR AUTOIMMUNITY -- 8 IMMUNOSTIMULATION INDUCED BY METALS: THE EXAMPLES OF PB, HG, AND NI -- 9 METAL-INDUCED AUTOIMMUNITY -- 10 ACCELERATION AND AGGRAVATION OF AUTOIMMUNITY BY XENOBIOTICS -- References -- Chapter 20 - Effects of Metallic Elements on Reproduction and Development -- 1 INTRODUCTION -- 2 HOW TO MEASURE DOSE AND EFFECT -- 3 GENDER DIFFERENCES -- 4 MECHANISM OF ACTION IN MALE AND FEMALE GERMINAL CELLS -- 5 THE ROLE OF HORMONES: METALLIC ELEMENTS AS ENDOCRINE DISRUPTORS -- 6 CONCEPTION -- 7 OTHER EFFECTS ON PREGNANCY -- 8 DEVELOPMENTAL EFFECTS -- 9 CONCLUDING REMARKS AND THE NEED FOR FUTURE RESEARCH -- References -- Chapter 21 - Ecotoxicology of Metals-Sources, Transport, and Effects on the Ecosystem -- 1 SOURCES OF METAL EMISSIONS -- 2 THE BIOGEOCHEMICAL TRANSPORT OF METALS -- 3 UPTAKE AND ACCUMULATION OF METALS -- 4 DEFENSE AGAINST AND STORAGE OF METALS.

5 TOXICITY OF METALS IN ECOSYSTEMS -- 6 RISK ASSESSMENT OF METALS -- 7 MONITORING METAL POLLUTION: BIOMONITORING -- 8 ECOTOXICOLOGY OF INDIVIDUAL METALS -- References -- Chapter 22 - Risk Assessment -- 1 INTRODUCTION -- 2 EXPOSURE AND DOSE ASSESSMENT -- 3 HAZARD IDENTIFICATION -- 4 DOSE-EFFECT AND DOSE-RESPONSE ASSESSMENT -- 5 RISK CHARACTERIZATION -- 6 RISK MANAGEMENT AND RISK COMMUNICATION -- References -- Chapter 23 - Diagnosis and Treatment of Metal Poisoning: General Aspects -- 1 Clinical Effects -- 2 DIAGNOSIS OF METAL POISONING -- 3 TREATMENT -- References -- Chapter 24 - Principles for Prevention of the Toxic Effects of Metals -- 1 INTRODUCTION -- 2 GENERAL PRINCIPLES FOR PREVENTION OF THE TOXIC EFFECTS OF METALS -- 3 PREVENTION OF THE EFFECTS OF METAL TOXICITY IN THE WORK ENVIRONMENT -- 4 PREVENTION OF THE EFFECTS OF METAL TOXICITY IN THE GENERAL ENVIRONMENT -- 5 PERSPECTIVES ON PRECAUTION AND PREVENTION -- References -- SIGNATORIES (ORGANIZING COMMITTEE OF THE BRESCIA WORKSHOP) -- Chapter 25 - Metal Toxicology in Developing Countries -- 1 INTRODUCTION -- 2 OVERVIEW OF PUBLIC HEALTH PROBLEM AREAS -- 3 DEVELOPING COUNTRIES AS GLOBAL SOURCES OF METALS -- 4 ARTISANAL GOLD MINING (MERCURY-OCCUPATIONAL EXPOSURES/SUBSISTENCE FISHING) -- 5 URANIUM MINING -- 6 AGRICULTURAL FERTILIZERS -- 7 METHODS FOR THE REMOVAL OF TOXIC METALS FROM WASTEWATER STREAMS IN DEVELOPING COUNTRIES -- 8 NEEDED PREVENTIVE ACTION AND RESEARCH INTO THE TOXICITY OF METALS IN HUMANS -- References -- Index -- e9780444594532v2 -- Front Cover -- Handbook on the Toxicology of Metals -- Copyright -- Preface -- Short Contents -- Full Contents -- List of Contributors -- List of Reviewers -- Volume II - Specific Metals -- Chapter 26 - Aluminum -- 1 PHYSICAL AND CHEMICAL PROPERTIES -- 2 METHODS AND PROBLEMS OF ANALYSIS -- 3 PRODUCTION AND USE.

4 DIETARY, ENVIRONMENTAL, AND OCCUPATIONAL EXPOSURES.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.