Cancer Biology : an Updated Global Overview.

Intro -- CANCER BIOLOGY: AN UPDATEDGLOBAL OVERVIEW -- CANCER BIOLOGY: AN UPDATED GLOBAL OVERVIEW -- Contents -- Introduction -- Cancer Definitionand Classification -- Classification of Tumors -- Malignant Tumors -- Cellular Carcinogenesis is aMonoclonal MultistepThreshold Phenomenon -- The Genetic and MolecularChanges Leading to Cancer Are ofFive Types -- Causes of Cancer -- Radiant Energy -- Chemical Carcinogens and Carcinogenesis -- Chemical Carcinogens Are Classified on Several Bases -- Mechanism of Chemical Carcinogenesis: Initiation and Promotion -- Free Radicals and Cancer -- Oncogenes/Tumor Suppressor Genes -- Oncogenes -- Functional and Locational Classifications of Proto-Oncogenes -- 1. Growth Factors -- 2. Growth Factor Receptors -- 3. Membrane Associated Signal Transducing Non-ReceptorTyrosine Kinases -- 4. Signal Transducing Serine/Threonine Kinases -- 5. Membrane Associated Signal Transducing G-Proteins -- 6. Nuclear DNA-Binding/Transcription Factors -- 7. Antiapoptotic Factors -- Mechanisms of Activation of the Proto-Oncogenes -- 1. Viral Promoter/Enhancer Insertion -- 2. Chromosomal Translocation -- 3. Gene Amplification -- 4. Point Mutation and Truncating Deletion -- 5. Modulation of Activity of Cellular Receptors -- 6. Altered Epigenetic Control of Gene Expression -- Detailed Examples of Oncogenes -- 1. The Ras-p21 Protooncogene: -- 2. The c-myc Protooncogene -- Tumor Suppresser Genes (or, Anti-Oncogenes) -- Functional and Locational Classifications of TumorSuppressor Genes -- 1. Transmembrane Receptors -- 2. Regulators of Receptor-Associating Transducing Proteins -- 3. Protein Kinase Inhibitors -- 4. Protein Phosphatases/Kinases -- 5. DNA-Binding and Transcription Factors -- 6. Proteins Involved in DNA Mutation Repair -- 7. Enhancers of Protein Degradarion -- 8. Proteins regulating mRNA Degradation.

9. Cell-Cell Adhesion and Signalling Proteins -- 10. Proapoptotic Factors -- Detailed Examples of Tumor Suppressor Genes -- 1. The p53 Gene -- 2. Retinoblastoma (RB) Gene -- Hereditary Predisposition and Age-Dependency of Cancer -- Cellular Changes AssociatingMalignant Transformation(Dedifferentiation) -- Tumor Recurrence and Metastasis -- Tumor Markers -- Specificity, Sensitivity and Predictivity of Tumor Markers -- Biomarkers For Exposure to Carcinogens -- Natural Inhibitors of theMultistage Carcinogenesis -- Biochemical Bases of CurrentAnticancer Treatments -- Conclusion -- References -- Cancer Etiology and Carcinogenesis: -- Chemical Carcinogens -- Tumor Suppressor Genes -- Oncogenes -- Oxidative Stress and Cancer -- Invasion, Metastasis and Microenvironment -- Tumor Markers -- Cancer Prevention -- Cancer Treatment -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.