Hematopoietic Stem Cell Transplantation : A Manual for Nursing Practice.

Title page -- Copyright -- Dedication -- Contributors -- Disclosures -- Licensing Opportunities -- Contents -- Preface -- 1 Overview of Hematopoiesis and Immunology -- Introduction -- Hematopoiesis and Immunology -- Across the Life Span -- Hematopoietic Structure and Function -- Immune Function: Cells and Responses -- Organs of the Immune System -- Summary -- References -- 2 Basic Concepts of Transplantation -- Introduction -- Types of Hematopoietic -- Stem Cell Transplants -- Nonmyeloablative Hematopoietic Sources of Stem Cells Stem Cell Transplantation -- Be The Match (National Marrow Donor Program) -- Preparative Regimens -- Clinical Evaluation -- Patient and Family Education -- Summary -- References -- 3 Current Research -- Introduction -- Scientific Review Committee -- Clinical Trials -- Institutional Review Board -- National Cancer Institute National -- Clinical Trials Network -- Resources for Clinical Investigation in -- Blood and Marrow Transplantation -- Nursing Research -- Gene Therapy -- Nonmalignant Diseases Treated With -- Hematopoietic Stem Cell Transplantation -- Summary -- References -- 4 Considerations in Program Development and Sites of Care -- Introduction -- Initial Program Development -- Care Continuum -- Interprofessional Team -- Nurse Leadership -- Transplant Nurses and Professional -- Development -- Resource Utilization -- Caregiver Support -- Professional Transplant Community -- Accreditation, Regulation, Quality Management and the Quality Plan -- Summary Outcomes: Data, Reporting, and the Stem Cell Therapeutic Outcomes Database -- References -- 5 Stem Cell Collection -- Introduction -- Bone Marrow Harvest -- Evaluation of Autologous and -- Allogeneic Donors for Collection -- Peripheral Blood Stem Cell Collection -- Mobilization of Stem Cells -- Apheresis Issues -- Allogeneic Blood Stem Cell Collection.

Mismatched and Haploidentical Donors -- Unrelated Blood Stem Cell Collection -- Pediatric Blood Stem Cell Collection -- Psychological and Ethical Issues -- Related to Stem Cell Donation -- Cord Blood Stem Cell Transplantation -- Stem Cell Processing -- Future Directions -- Stem Cell Manipulation -- Summary -- References -- 6 Transplant Treatment Course and Acute Complications -- Introduction -- Conditioning Regimens for Hematopoietic -- Stem Cell Transplantation -- Cellular Infusion of Hematopoietic -- Stem Cells -- After Stem Cell Infusion -- Engraftment Phase -- Summary -- Patient and Caregiver Education -- References -- 7 Acute and Chronic Graft-Versus-Host Disease -- Introduction -- Definitions -- Acute Graft-Versus-Host Disease -- Chronic Graft-Versus-Host Disease -- Preventing and Treating Acute and -- Chronic Graft-Versus-Host Disease -- Strategies for Prophylaxis and Treatment -- Components of Supportive Care -- Preclinical and Developmental Strategies -- for Prophylaxis, Treatment, and Control -- Induction of Graft-Versus-Host Disease: -- Preserving the Graft-Versus-Tumor Effect -- Summary -- References -- 8 Hematologic Effects -- Introduction -- Neutropenia -- Thrombocytopenia -- Anemia -- Blood Product Transfusions -- Delayed Engraftment -- Late Post-Transplant Infections (More Than 100 Days) -- Summary -- References -- 9 Gastrointestinal Complications -- Introduction -- Mucositis -- Salivary Gland Dysfunction -- and Xerostomia -- Nutrition -- Taste Changes -- Nausea and Vomiting -- Diarrhea -- Summary -- References -- 10 Hepatorenal and Bladder Complications -- Introduction -- Hepatic Sinusoidal Obstruction Syndrome -- Hepatitis -- Kidney Injury -- Transplant-Associated -- Thrombotic Microangiopathy -- Hemorrhagic Cystitis -- Summary -- References -- 11 Cardiopulmonary Complications -- Introduction -- Pulmonary Complications.

Nursing Care of Pulmonary Complications -- Cardiac Complications -- Nursing Care of Cardiac Complications -- Summary -- References -- 12 Neurologic Complications -- Introduction -- Neurotoxicities of Common Agents -- Neurotoxicities of Infectious Diseases -- Other Causes of Neurologic -- Complications -- Neurocognitive Dysfunction -- Long-Term Neurotoxicities -- Summary -- References -- 13 Relapse and Subsequent Malignancies -- Introduction -- Relapse After Hematopoietic -- Stem Cell Transplantation -- High -- Low -- Subsequent Malignancies After -- Hematopoietic Stem Cell Transplantation -- Summary -- References -- 14 Late Effects and Survivorship Care -- Introduction -- Survivorship Care -- Late Infectious Complications -- Vaccinations -- Organ-Specific Toxicities -- Relapse and Subsequent Malignancies -- Health-Related Quality of Life -- Caregivers -- Summary -- References -- 15 Ethical Considerations -- Introduction -- Transplantation as a Treatment Option: -- Beneficence and Nonmaleficence -- Informed Consent: Autonomous Decision -- Patient Education: Preparing -- for Treatment Outcomes -- Donor Issues -- Outcomes of Disease and Treatment: -- Undesirable Consequences -- Summary -- References -- 16 Emerging Cellular Therapies: Chimeric Antigen Receptor T Cells -- Introduction -- Overview of the Immune System -- and Immunotherapy -- Building a Chimeric Antigen -- Receptor T Cell -- Mechanism of Action -- Pivotal Trials -- U.S. Food and Drug Administration -- Approval -- Five Steps to Chimeric Antigen -- Receptor T-Cell Therapy -- Toxicities and Side Effects of Chimeric -- Antigen Receptor T-Cell Therapy -- Building an Immunotherapy Program: -- Teams and Infrastructure -- Summary -- References -- 17 Professional Practice -- Introduction -- Professional Regulation -- Hematopoietic Stem Cell Transplantation -- Nursing Specialty -- Education.

Self-Care -- Advocacy -- Communication -- Interprofessional Collaboration -- Leadership -- Professional Practice Evaluation -- Evidence-Based Practice -- Research -- Summary -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.