Enteroviruses : Omics, Molecular Biology, and Control.

Intro -- Contents -- Current Books of Interest -- Preface -- 1 Enteroviruses Future -- Introduction -- Curiouser and curiouser -- Viral eradication and control by vaccination -- Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses -- Enteroviruses in 10 years -- 2 Enterovirus Receptors and Entry -- Introduction -- The Enterovirus capsid -- Attachment to a cellular receptor -- Use of multiple receptors -- Uncoating: formation of expanded A-particles -- Uncoating: RNA release -- Where does uncoating occur? -- Introduction to endocytosis -- Other forms of endocytosis -- Post-internalization events -- Concluding thoughts -- 3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses -- Introduction -- Viral proteinase disruption of host machinery -- Use and abuse of host cell functions for viral translation and RNA replication -- Evasion of host antiviral and stress response pathways and mRNA surveillance -- Summary -- 4 The Omics of Rhinoviruses -- The Rhinoviruses -- How RV taxa are defined -- Making an informative alignment -- Prediction of an RV-C capsid -- Statistical prediction of immunogenicity -- Other uses for RV sequences -- 5 Viral Population Dynamics and Sequence Space -- Quasispecies dynamics of Enteroviruses: model RNA viruses -- Mutation rates and RdRp fidelity -- Recombination -- Sequence space and fitness landscapes -- Viral adaptation dynamics: step-wise walks along the landscape -- Intra-population interactions: complementation and interference -- Group contribution of minority variants to phenotype -- The genomics era: challenges and prospects of high-throughput sequencing technologies -- Final conclusions -- 6 Enterovirus Control of Cytoplasmic RNA Granules -- Cytoplasmic RNA granules -- Mechanisms of stress granule assembly.

Enterovirus relationships with stress granules: antagonism rules -- How does G3BP cleavage block stress granule assembly? -- Enterovirus relationships with P-bodies: rapid destruction -- Why Enteroviruses must antagonize RNA granules -- Future directions -- 7 The Autophagic Pathway and Enterovirus Infection -- Autophagy was first identified in Enterovirus infections through electron microscopy -- Basics of autophagy -- The relationship between Enteroviruses and autophagy -- Release of Enteroviruses without lysis -- Enterovirus proteins promote autophagic signalling and degradation -- Triggering of autophagy upon virus entry -- Coxsackievirus regulation of the autophagy pathway -- Enterovirus 71 -- Rhinovirus -- The dual nature of autophagy -- The current model -- 8 The Lipid Blueprints of Replicating Viral Genomes -- Introduction -- Membranes facilitate replication -- Convergence on a common lipid blueprint -- Advantages of enriching for PI4P lipids in replication organelles -- Mechanisms and consequences of viral induction of PI4P lipid production -- Phosphatidylethanolamine -- Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains -- Viral mechanisms of obtaining cholesterol -- Therapeutic potential of targeting lipids and future directions -- Index.

This book represents a comprehensive tour of the current most important enterovirus research. The editors, Dr. Jackson and Dr. Coyne, have assembled a group of enteroviral experts who cover topics including viral entry and the hijacking of host functions; the dynamic analysis of ever-evolving virus genomes; the cellular membrane changes promoting virus assembly and release. This volume is a must-read for anyone with an interest in this family of viruses and an important acquisition for all microbiology libraries.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.