Stem Cells Research Compendium, Volume 1.

Intro -- Stem Cells Research Compendium Volume 1 -- Contents -- Preface -- Foreword: Stem Cells -- Megakaryocytopoiesis: From Marrow Stem Cells to Circulating Platelets -- Abstract -- Development of Megakaryocytes -- Megakaryocyte Differentiation and Maturation -- Thrombocytopoiesis -- Summary -- Acknowledgments -- References -- A Novel Serum-Free Culture System for the Analysis of Human Hematopoietic Progenitor Cells -- Abstract -- Introduction -- Materials and Method -- Results -- Discussion -- Acknowledgments -- References -- Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures -- Abstract -- Introduction -- Therapeutic Potential of BMSSC for Bone Regeneration -- The Role of Biomaterials in Bone Repair -- Therapeutic Potential of Genetically Modified BMSSC -- Alternative Sources of MSC -- Conclusion -- Acknowledgments -- References -- Adult Neural Stem Cells and Cellular Therapy -- Abstract -- Introduction -- Adult Neurogenesis and Neural Stem Cells -- Adult Neural Stem Cells and Cellular Therapy -- Adult Neural Stem Cells a Model of Choice for Cellular Therapy for CNS Diseases and Injuries -- Conclusion -- Acknowledgments -- References -- The Cardiogenic Potential of Mouse and Human Embryonic Stem Cells: Cognitive Research to Envision the Therapeutic Use of the Cells -- Abstract -- Introduction: The Need for Stem Cell Therapies in Cardiology -- Cardiac Potential of Embryonic Stem Cells -- Transcriptional Regulation of ESC Cardiac Specification -- Differences in Early Cardiac Development of Mouse and Primate Embryo -- Prospective Research -- References -- Hemopoietic Stem Cells and Autoimmunity: Impaired Mechanisms of Thymic Selection or Genetic Predisposition? -- Abstract -- Abbreviations -- Introduction -- Embryogenesis of the Thymus -- Cellular Composition of the Thymus.

Origin of Hemopoietic Stem Cells in the Thymus -- The Role of Notch in T Cell Development -- Studies of Thymic Function -- Generation of T Cell Repertoire through Thymic Selection: Cellular and Molecular Events -- Regulation of Thymocyte Egress -- The Thymus and Autoimmunity: Previous Observations in Thymus-Deficient Mice -- The Role of AIRE Protein in Protection against Autoimmunity -- Regulatory T Cells and Autoimmunity -- The Role of the Thymus in Autoimmunity: Perspectives for Future Research -- Stem Cells in the Treatment of Autoimmunity -- Concluding Remarks -- Acknowledgments -- References -- Control of Tissue Regeneration through Oxygen Concentrations -- Abstract -- Introduction -- How Cells Can Respond to the Local Oxygen Environment -- Stem Cell Proliferation and Mobilization -- Cellular Homing to Injured Tissue in Response to Oxygen -- Cellular Differentiation in Response to Oxygen -- Conclusions -- References -- Control of Thymocyte Proliferation and Thymus Organ Size by CDK Inhibitors P18INK4C and P27KIP1 -- Abstract -- Introduction -- Materials and Methods -- Results -- Conclusion -- Acknowledgments -- References -- Human Embryonic Stem Cell-Derived Cardiomyocytes: Therapeutic Potentials and Limitations -- Abstract -- Pluripotent Embryonic Stem, Germ and Carcinoma Cells -- Heart Disease and Motivation for Cell-Based Therapy -- Cardiac Differentiation - Insights from Studies with Mouse ESCs -- Selection of the Cardiac Lineage from Differentiated mESCs -- Human vs Mouse ESCs: Similarities and Differences -- Therapeutic Potential -- Conclusion -- Acknowledgments -- References -- Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors -- Abstract -- Abbreviations -- Introduction -- Embryonic Stem Cells During Aging: Regulation of Senescence -- Genetics of Aging Models.

Role of the Microenvironment and Niches for Stem Cells During Aging -- Changes Produced in Neural and Hematopoietic Niches by HIV Infection: Niche Pathology or Defective Ecotaxis -- Mapping of Genes of Lifespan, Using RI, Stem Cells and Studies of Niches -- Influence of Nutrition on the Decline of Immunity with Aging in Mice -- MHC Genes in Aging -- Discussion -- Concluding Remarks: Perspectives for Future Research in Aging -- Acknowledgments -- References -- Stem Cells in Aging: Contribution of the Immune System -- Abstract -- Abbreviations -- Introduction -- Early Models of T Lymphocyte Development -- Current Studies of the Effects of Aging on Lymphocyte Development from Hemopoietic Stem Cell Progenitors -- Biochemical Basis for Age-Related Developmental Changes in T Cells -- The Role of Apoptosis in Aging -- Contribution of the Thymic Microenvironment (Temporary Niche) to Aging -- Approaches to Restore Thymic Function in Humans as Related to Aging, Autoimmunity and Aids -- Thymic Function During Human Development -- Analysis of the Thymic Output -- Influence of Nutrition on the Decline of Immunity with Aging in Mice -- Signaling by Immune Receptors in Aging and Autoimmunity -- Roles of Niches, Cytokines, T, B and NK Cells -- Future Perspectives for Stem Cell Research Related Immunology of Aging -- Acknowledgments -- References -- Diminished Gene Expression in Human Mesenchymal Stem Cells by Mutation of Focal Adhesion Kinase Signalling -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Acknowledgments -- References -- Stem Cells as Therapy for Cardiovascular Disease: Lost in Translation? -- Abstract -- Introduction -- Cardiac Disease Amenable to Stem Cell Therapies -- Acute Myocardial Infarction -- Chronic Heart Failure -- Animal Models of Infarction and Heart Failure -- Induced Myocardial Infarction.

Models of Chronic Myocardial Ischemia and Critical Limb Ischemia -- Stem Cell Types Suitable for Cardiovascular Therapy -- Adult Bone Marrow Stem Cells -- Circulating Stem Cells -- Adult Skeletal Myoblasts -- Adult Adipose Stem Cells -- Embryonic Stem Cells -- Clinical Trials - the Discrepancy with Preclinical Studies -- References -- Human Chimerism and Tetragametism: Relevance of Embryonic or/and Hematopoietic Stem Cells -- Abstract -- Polymorphic DNA Markers -- Chimerism -- Hematopoietic Chimerism (Materno-Fetal) -- Hematopoietic Chimerism (Fetomaternal) -- Twins -- Freemartins -- Fusion of Embryos -- Fusion of Embryos with Evidence of Hematopoietic Monoclonality -- Discussion -- Acknowledgments -- References -- Mathematical Modeling of T Cell Differentiation from Hemopoietic Stem Cell Progenitors -- Abstract -- Abbreviations -- Introduction -- Cellular and Molecular Interactins in the Course of Thymic Selection and the Generation of the T Cell Repertoire -- Pathways of T Lymphocyte Development -- Feedback Loops in T Lymphocyte Development -- Model and Results -- The Challenge - Modeling Lymphocyte Repertoire Development and Function -- Future Directions -- Conclusion -- Acknowledgments -- References -- The Importance of Large Animal Models in Stem Cell Research -- Abstract -- I. Benefits of Large Animal Models -- II. Characterization of ES Cell Lines in Large Animals -- III. Safety and Efficacy -- IV. Adult Stem Cells -- V. A Promising Future -- VI. Conclusion -- References -- Hypoxia Expands Primitive Hematopoietic Progenitor Cells from Mouse Bone Marrow During In Vitro Culture and Preserves the Colony-Forming Ability -- Abstract -- Abbreviations -- Introduction -- Materials and Methods -- Cobblestone Area-Forming Cells -- Results -- Discussion -- Acknowledgments -- References.

A Versatile Method for Differentiation of Multiple Neuronal Subtypes from Mouse Embryonic Stem Cells -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Conclusion -- Acknowledgments -- References -- Signaling Pathways Involved in the Maintenance of Human Embryonic Stem Cells -- Abstract -- Introduction -- 1. LIF -- 2. bFGF -- 3. The Transforming Growth Factor (TGF) b Signaling -- 4. Wnt -- 5. Sphingosine-1-Phosphate (S1P) and Platelet-Derived Growth Factor (PDGF) -- 6. Neurotrophins -- Conclusion -- Acknowledgments -- References -- Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host that Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients -- Abstract -- Introduction -- SCID-hu Mice as a Model of Hematopoiesis in Human Bone Marrrow -- Thrombocytopenia -- Anemia and/or HIV-1 Infection of Red Blood Cells -- Neutropenia -- Conclusion -- Acknowledgments -- References -- The Effects of Ex Vivo Expansion on the Differentiation of Umbilical Cord Blood-Derived CD34+ Cells -- Abstract -- Introduction -- Materials and Methods -- Results -- Discussion -- Acknowledgments -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.