Advanced Topics in Forensic DNA Typing : Interpretation.

Front Cover -- Contributors -- ADVANCED TOPICS IN FORENSIC DNA TYPING: INTERPRETATION -- Copyright -- Dedication -- Contents -- Foreword -- Introduction -- NEW MATERIAL IN THIS VOLUME -- OVERVIEW OF BOOK CHAPTERS -- References -- Acknowledgments -- Reference -- About the Author -- Reference -- SECTION I - DATA INTERPRETATION -- Chapter 1 - Data Interpretation Overview -- PURPOSE OF THIS BOOK -- THE INTERPRETATION PROCESS -- CHARACTERISTICS OF IDEAL DATA -- GUIDANCE FOR DNA INTERPRETATION -- A MATCH OR NOT A MATCH: THAT IS THE QUESTION… -- STR LOCI, KITS, AND POPULATION DATA -- SUMMARY -- Reading List and Internet Resources -- Chapter 2 - Data, Models, Thresholds -- DATA COLLECTION IN ABI GENETIC ANALYZERS11CERTAIN COMMERCIAL EQUIPMENT, INSTRUMENTS, AND MATERIALS ARE IDENTIFIED IN ORDER ... -- MODELS -- THRESHOLDS USED IN STR TYPING -- SETTING AND USING ANALYTICAL THRESHOLDS -- Reading List and Internet Resources -- Chapter 3 - STR Alleles and Amplification Artifacts -- INTRODUCTION -- OVERVIEW OF THE STR TYPING PROCESS -- STR ALLELES AND THEIR MEASUREMENT -- VARIANT AND "OFF-LADDER" ALLELES -- ARTIFACTS OF STR ALLELE AMPLIFICATION -- NON-TEMPLATE ADDITION -- STUTTER PRODUCTS -- NULL (SILENT) ALLELES -- Reading List and Internet Resources -- Chapter 4 - STR Genotypes: Heterozygote Balance, Stochastic Thresholds, Allele, and&amp -- nbsp -- Concordance Studies -- IMPORTANCE OF GENOTYPES VS. ALLELES -- PEAK HEIGHT RATIOS -- STOCHASTIC THRESHOLDS AND ALLELE DROP-OUT -- CONCORDANCE STUDIES AND NULL ALLELES -- Reading List and Internet Resources -- Chapter 5 - STR Profiles: Multiplex PCR, Tri-Alleles, Amelogenin, and Partial Profiles -- INTRODUCTION -- MULTIPLEX PCR CHALLENGES -- STR PROFILE EVALUATION -- TRI-ALLELIC PATTERNS -- GENDER IDENTIFICATION WITH AMELOGENIN -- PARTIAL DNA PROFILES -- Reading List and Internet Resources.

Chapter 6 - DNA Mixtures -- GENERAL INFORMATION -- TOOLS FOR MIXTURE INTERPRETATION -- ELEMENTS OF MIXTURE INTERPRETATION -- RESOURCES AND GUIDANCE ON MIXTURE INTERPRETATION -- COMPLICATING FACTORS IN MIXTURE DECONVOLUTION -- Reading List and Internet Resources -- Tools for Mixture Interpretation -- Elements of Mixture Interpretation -- Resources to Aid Mixture Interpretation -- Chapter 7 - Low-Level DNA and Complex Mixtures -- INTERPRETATION CHALLENGES WITH LOW TEMPLATE DNA -- LOW-QUANTITY AND LOW-QUALITY DNA -- PROBABILISTIC GENOTYPING -- HIGH-DENSITY SNP ARRAYS? -- MORE POOR-QUALITY SAMPLES BEING SUBMITTED -- A COMPLEXITY THRESHOLD? -- Reading List and Internet Resources -- Chapter 8 - Troubleshooting Data Collection -- INTRODUCTION -- PRINCIPLES AND PROCESSES INVOLVED WITH CAPILLARY ELECTROPHORESIS -- INSTRUMENT MAINTENANCE &amp -- COMMON PROBLEMS -- RECOMMENDED STEPS FOR TROUBLESHOOTING -- SUMMARY -- Reading List and Internet Resources -- SECTION II - STATISTICAL INTERPRETATION -- Chapter 9 - Statistical Interpretation Overview -- ROLE OF STATISTICS IN FORENSIC DNA -- PROBABILITY -- STATISTICS -- Reading List and Internet Resources -- Chapter 10 - STR Population Data Analysis -- INTRODUCTORY GENETIC PRINCIPLES -- POPULATION DATA -- GENETIC MODELS AND FORMULAS -- PRACTICAL CONSIDERATIONS -- SUMMARY -- Reading List and Internet Resources -- Chapter 11 - DNA Profile Frequency Estimates and Match Probabilities -- INTRODUCTION -- PROFILE FREQUENCY ESTIMATE CALCULATIONS -- LIKELIHOOD RATIO -- SOURCE ATTRIBUTION -- ISSUES WITH DNA PROFILE FREQUENCY ESTIMATES -- SUMMARY -- Reading List and Internet Resources -- Chapter 12 - DNA Mixture Statistics -- INTRODUCTION -- DIFFERENT STATISTICAL APPROACHES TO MIXTURE INTERPRETATION -- REPORTING MATCH PROBABILITIES ON DEDUCED COMPONENTS -- RANDOM MAN NOT EXCLUDED (RMNE) -- LIKELIHOOD RATIOS -- ADDITIONAL TOPICS.

Reading List and Internet Resources -- Chapter 13 - Coping with Potential Missing Alleles -- INTRODUCTION TO THE PROBLEM -- PROBABILISTIC GENOTYPING - A WAY FORWARD -- Reading List and Internet Resources -- Chapter 14 - Relationship Testing: Kinship Statistics -- INTRODUCTION -- PARENTAGE TESTING -- MUTATIONS AND MUTATION RATES -- OTHER TOPICS WITH PARENTAGE TESTING -- MISSING PERSONS &amp -- DISASTER VICTIM IDENTIFICATION -- COMPLEX KINSHIP ANALYSIS -- Reading List and Internet Resources -- Chapter 15 - Lineage Marker Statistics -- LINEAGE MARKER INHERITANCE PATTERNS -- GUIDANCE ON INTERPRETATION -- GENERATING LINEAGE MARKER HAPLOTYPES -- POPULATION DATABASES FOR LINEAGE MARKERS -- GENETIC MODELS AND REPORTING -- SUMMARY THOUGHTS -- Reading List and Internet Resources -- Chapter 16 - Laboratory Reports: Communicating Results and Conclusions -- INTRODUCTION -- DRAWING CONCLUSIONS -- REPORT WRITING -- REPORT &amp -- CASE REVIEW -- REPORT RELEASE -- REPORT COMPREHENSION AND POTENTIAL MISUSE -- SUMMARY -- Reading List and Internet Resources -- Appendix 1 - STR Allele Frequencies from U.S. Population Data -- References -- Appendix 2 - NRC I &amp -- NRC II Recommendations -- NRC I (1992) -- NRC II (1996) -- Reading List and Internet Resources -- Appendix 3 - DAB Recommendations on Statistics -- INTRODUCTION -- SOURCE ATTRIBUTION -- RELATIVES -- MIXTURES -- DATABASE SEARCH -- CONCLUSION -- References -- Appendix 4 - Worked Mixture Example -- INTRODUCTION -- MIXTURE ASSESSMENT AND DECONVOLUTION -- STATISTICAL EVALUATION -- CONCLUSIONS -- Acknowledgments -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.