Phage Therapy : Current Research and Applications.

Intro -- Contents -- Contributors -- Current books of interest -- Foreword -- Introduction -- Part I: Characteristics of Phages as Antibacterial Agents -- 1: General Characteristics of Bacteriophages -- Introduction -- Discovery -- Basic phage techniques (Carlson, 2005) -- Habitats and ecology -- Phage life -- Host range -- Classification -- Genomics -- Practical aspects of phage research -- Electron microscopy for rapid diagnosis (Ackermann and Heldal, 2009 -- Ackermann, 2009) -- Outlook -- 2: The First Step to Bacteriophage Therapy: How to Choose the Correct Phage -- Introduction: therapeutic phages - what requirements should they meet? -- Environmental sources of therapeutic phages -- A brief overview of phage isolation methods -- The selection of phages that infect encapsulated bacterial cells -- Preliminary grouping of phage isolates -- Pre-selection of potential therapeutic phages -- Perspectives for the prediction of phage therapeutic efficacy -- Purification of phage lysates -- Bacteriophage stability -- Host range determination -- Bacterial strains for therapeutic phage propagation -- Bacterial phage resistance - is it a concern? -- Concluding remarks -- 3: Bacteriophages as Drugs: The Pharmacology of Phage Therapy -- Introduction -- Pharmacology -- Primary pharmacodynamics -- Secondary pharmacodynamics -- Accumulation rates -- Concentrations -- Absorption and distribution -- Spectrum of activity -- Development issues -- Conclusion -- 4: Fighting Bacteriophage Infection: Mechanisms of Bacterial Resistance -- Introduction -- Preventing phage adsorption -- Preventing phage DNA entry -- Degradation of phage nucleic acids -- Abortive infection systems -- Conclusion -- 5: Non-bactericidal Effects of Phages in Mammals -- Introduction -- Phages and cell adhesion -- Overview of main aspects of phage antigenicity.

The influence of phages on cytokine production -- Phage influence on phagocytosis and oxidative burst -- Engineered phages as vaccines -- Phages and pathogenic viruses of mammals -- Remarks on bacterial remains in phage preparations -- Conclusions -- Part II: Applications of Phages and Phage-derived Enzymes as Antibacterials -- 6: Overview of Therapeutic Applications of Bacteriophages -- The use of lytic phages -- The therapeutic use of phage lysins -- Genetically engineered phages -- Phages as delivery vectors -- 7: Considerations for Using Bacteriophages in Plant Pathosystems -- Introduction -- Impediments in using phage therapy in plant pathology -- Future considerations for improving phage efficacy -- Phages as part of integrated management strategy -- Conclusions -- 8: Bacteriophage Therapy in Animal Production -- Introduction -- Bacteriophage therapy in poultry production -- Bacteriophage therapy in swine production -- Bacteriophage therapy in beef, dairy and cattle production -- Bacteriophage therapy in aquaculture -- General discussion -- 9: The Use of Phages as Biocontrol Agents in Foods -- Introduction -- Bacteriophages as biocontrol agents -- The use of phages as biocontrol agents against specific food-borne bacteria -- Main factors that determine the efficacy of phages as biocontrol agents -- Can phages adversely affect any properties of foods? -- Concluding remarks -- 10: Phage Therapy: Experiments Using Animal Infection Models -- Introduction -- Two directions in experimental phage therapy: phage particles versus their products -- Bacterial species and infections targeted in experimental phage therapy -- Model animals used for phage therapy experiments -- Pharmacokinetics of phages -- Experimental phage therapy -- Safety of phage therapy -- Conclusions -- 11: Clinical Phage Therapy -- Introduction.

Randomized controlled trials of phage therapy -- Earlier studies of phage therapy in the West -- Phage therapy in Poland -- Phage therapy in Georgia and Russia -- Concluding remarks -- 12: Reintroducing Phage Therapy in Modern Medicine: The Regulatory and Intellectual Property Hurdles -- Introduction -- Bacteriophage: a sustainable, evolving and self-amplifying drug -- Ethical considerations -- The Declaration of Helsinki -- Routine therapeutic application and marketing -- Other potential paths -- Intellectual property rights -- Conclusions -- 13: The Use of Bacteriophages and Bacteriophage-derived Enzymes for Clinically Relevant Biofilm Control -- Introduction -- Biofilm structure and composition -- Clinically relevant biofilms -- Antibiotic tolerance of biofilm -- Biofilm-phage interactions -- In vitro efficacy studies of phages and phage-derived enzymes -- Potential application of phages to control biofilms -- Future trends -- 14: Using What Phage Have Evolved to Kill Pathogenic Bacteria -- Background -- Structural characteristics of lysins -- Mechanism of action -- Lysin efficacy -- Lysin synergy with other lysins and antibiotics -- Animal models of infection -- Bacterial resistance to lysins -- Identifying and isolating new lysins -- Concluding remarks -- 15: Genetically Engineered Phage as Antimicrobials and Biodetectors -- Introduction -- Genetically engineered phage -- Conclusion -- Future trends -- 16: Engineered Filamentous Bacteriophages as Targeted Anti-bacterial Drug-carrying Nanomedicines -- Introduction -- The biology of Ff phage -- Phage display -- Monovalent versus polyvalent display -- Targeting of the phage to specific bacteria -- Drug-carrying filamentous phages -- In vivo characterization of anti-S. aureus Neo-CAM-carrying phages -- Future trends -- Index.

This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.