The Diagnosis and Treatment of Male Infertility : A Case-Based Guide for Clinicians.

Intro -- Foreword -- Preface -- Contents -- Editors and Contributors -- Contributors -- 1 Making a Diagnosis -- Introduction -- The Initial Assessment -- Semen Analysis -- Advanced Semen Studies -- Oxidative Stress -- Sperm DNA Fragmentation -- Sperm Viability -- Anti-sperm Antibody (ASA) Testing -- Post-ejaculatory Urinalysis -- Hormonal Evaluation -- Genetic Testing -- Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene -- Ultrasonography -- Scrotal Ultrasonography -- Transrectal Ultrasonography -- Vasography -- Magnetic Resonance Imaging -- Pelvic Imaging -- Pituitary Gland Imaging -- Conclusion -- References -- 2 Interpreting Semen Analysis and Level 2 Sperm Testing -- Introduction -- The Reliability of Semen Analysis Result -- Standardization of Semen Analysis Techniques -- Biological Variability -- External Technical Factors that May Influence Semen Analysis Result -- Does the Traditional Semen Analysis Identify a Specific Pathology? -- The Significance of Semen Volume -- The Significance of Semen pH -- The Value of Semen Analysis in Azoospermic Cases -- Can This Man Achieve a Pregnancy Given His Female Partner's Fertility Potential? -- Level 2 Sperm Testing -- References -- 3 Medical and Lifestyle Approaches to Improving Semen Quality -- Clinical Vignette -- Lifestyle Approaches to Improving Semen Quality -- Smoking -- Alcohol -- Exogenous Testosterone and Anabolic Steroids Abuse -- Medical Approaches to Improving Semen Quality -- Selective Estrogen Receptor Modulators -- Aromatase Inhibitors -- Gonadotropins -- Conclusion -- References -- 4 Testosterone and Anabolic Steroid Abuse -- Introduction -- Biophysiology of Testosterone -- Synthesis -- Transport -- Metabolism -- Regulation of Testosterone Production -- Hypothalamic Pituitary Gonadal Axis -- Paracrine Regulation of Testosterone Production.

Physiological Functions of Testosterone -- What Are the "Anabolic Steroids"? -- Testosterone and Anabolic Steroids Abuse -- Nonmedical (Athletic) AAS Abuse -- Clinical Case Scenario 1 -- The Therapeutic Use of Testosterone -- Clinical Case Scenario 2 -- Effects of Testosterone and Anabolic Steroid Abuse -- Effects on Male Fertility -- Effect on Sexual Function -- Other Effects of Testosterone and Anabolic Steroid Abuse -- Cardiovascular Effects -- Hepatic -- Musculoskeletal -- Subcutaneous Tissue -- Neuropsychiatric -- Diagnosis of Testosterone and Anabolic Steroid Abuse -- Management of Testosterone and Anabolic Steroid Abuse -- Male Infertility Management -- Selective Estrogen Receptor Modulators -- Human Chorionic Gonadotropin -- Human Chorionic Gonadotropin and Testosterone -- Aromatase Inhibitors (Anastrozole and Letrozole) -- Sexual Dysfunction Management -- Conclusion -- References -- 5 Managing Infertility Due to Endocrine Causes -- Introduction -- Case Report -- Male Hypogonadism -- Hyperprolactinemia -- Thyroid Diseases -- Obesity and Metabolic Syndrome -- Evaluation of an Infertile Man from an Endocrinological Point of View -- Therapy -- Treatment of Male Hypogonadism -- Hormonal Treatment of Idiopathic Infertility -- Treatment of Hyperprolactinemia and Thyroid Disorders -- Conclusion -- References -- 6 Management of Infections in Male Infertility -- Introduction -- Sites of Infection -- Urethritis -- Epididymitis -- Orchitis -- Prostatitis -- Types of Organisms -- Neisseria Gonorrhea -- Chlamydia trachomatis -- Mycoplasma -- Herpes Virus Family -- Human Papillomavirus -- Human Immunodeficiency Virus -- Mumps -- Other Organisms -- Markers of Inflammation -- Leukocytospermia -- Oxidative Stress and Reactive Oxygen Species -- DNA Fragmentation -- Anti-sperm Antibodies -- Treatment of Inflammation -- Antibiotics -- Antioxidants.

COX-2 Inhibitors and Antihistamines -- Conclusion -- References -- 7 Ejaculatory Dysfunction: Retrograde Ejaculation -- Introduction -- Clinical Vignette -- Pathophysiology -- Diagnosis and Workup -- Etiologies of Retrograde Ejaculation -- Neuropathic Changes -- Postsurgical -- Medication Side Effects -- α(Alpha)-Antagonists -- Antipsychotic Medications -- Spinal Cord Injury -- Treatment of Retrograde Ejaculation -- Noninvasive Techniques -- Medical Therapy -- Sperm Retrieval -- Surgical Therapy -- Conclusion -- References -- 8 Management of Azoospermia -- Introduction -- Classification -- Non-obstructive Azoospermia -- Pre-testicular -- Testicular -- Obstructive Azoospermia (Post-testicular) -- Case Scenario 1 -- Clues Toward Diagnosis of Non-obstructive Azoospermia -- History and Medical Examination -- Investigations -- Management of Non-obstructive Azoospermia -- Optimizing Lifestyle Factors -- Correction of Reversible Causes -- Case Scenario 2 -- Clues Toward Obstructive Azoospermia -- History and Medical Examination -- Investigations -- Management of Obstructive Azoospermia -- Counseling -- Surgical Correction of Obstructive Azoospermia -- Surgical Sperm Retrieval -- References -- 9 Klinefelter Syndrome -- Introduction -- Genetic Background -- Endocrine Function and Spermatogenesis in Klinefelter Syndrome -- Clinical Manifestations -- Case Scenario 1 -- Case Scenario 2 -- Diagnosis -- Management -- Managing Hypogonadism -- In Adolescents and Adults -- Fertility Management -- Peripubertal KS Boys -- Cryopreservation in Adolescents -- Adult Klinefelter Syndrome Men -- Genetics Risks to Offspring -- Conclusion -- References -- 10 CFTR-Related Male Infertility -- Clinical Vignette -- What Is CFTR? -- How Common Is CFTR-Related Male Infertility? -- How Does CFTR-Related Male Infertility Present? -- How Do CFTR Mutations Cause Male Infertility?.

Can CFTR Mutations Cause Non-CBAVD Infertility? -- Does the Type of CFTR Mutation Determine the Phenotype? -- How Are CFTR Mutations Detected and Reported? -- Which CFTR Mutations Are Common in CBAVD Patients? -- IVS8-5T and the C.350G greaterthan A Alleles -- Medical Management of Men with Biallelic CFTR Mutations -- Management of Men with no CFTR Mutations -- Genetic Counseling -- Fertility and Pregnancy Outcomes -- Screening of Gamete Donors -- References -- 11 Sperm Retrieval Techniques -- Introduction -- Preoperative Preparation -- Case Scenarios -- Case 1 -- Options of Sperm Retrieval Procedures -- Selection and Results of Sperm Retrieval Technique in Post-vasectomy Patients -- Artificial Reproductive Technology Outcomes in Men with Obstructive Azoospermia -- Case 2 -- Preoperative Investigations and Optimization -- Procedures in Men with Previous Failed Sperm Retrieval -- Sperm Retrieval Procedures for Men with Nonobstructive Azoospermia -- Prognostic Factors -- Fresh Versus Cryopreserved Retrieved Testicular Sperm -- Postoperative Care -- Conclusion -- References -- 12 Varicocele: Surgical Intervention Versus Assisted Conception -- Introduction -- Clinical Vignette -- Incidence -- Pathophysiology -- Anatomy -- Pathophysiology -- Diagnosis -- Ultrasound -- Venography -- Other Diagnostic Modalities -- Semen Characteristics -- Treatment -- Indications -- Percutaneous Treatment -- Surgical Repair -- Complications -- Semen Analysis Outcomes -- Outcomes in Azoospermic Men -- Testosterone -- Pregnancy Rates -- Varicocele Repair and Assisted Reproductive Technology -- Conclusion -- References -- 13 Treating Erectile Dysfunctions -- Introduction -- Erectile Physiology and Pathophysiology -- Case Scenario -- Management of Patients with Erectile Dysfunction -- Workup -- Specialized Diagnostic Tests -- Treatment -- First-Line Therapy.

Oral Pharmacotherapy -- Sildenafil -- Tadalafil -- Vardenafil -- Avanafil -- Side Effects and Safety Precautions -- Cardiovascular Safety -- Nitrate Use -- Alpha Blockers -- Dosage Adjustment -- Vacuum Erection Devices (VED) -- Low Intensity Shockwave Therapy (LISWT) -- Second-Line Therapy -- Intracavernosal Injections -- Intraurethral Alprostadil -- Third-Line Therapy -- Penile Prosthesis Implantation -- Conclusion -- References -- 14 Spinal Cord Injury Related Infertility -- Introduction -- Pathophysiology -- Erection -- Ejaculation -- Sperm Retrieval in Men with SCI -- Penile Vibratory Stimulation -- Technique -- Prognostic Factors -- Success -- Electro-Ejaculation -- Technique -- Prognostic Factors -- Success -- Surgical Sperm Retrieval -- Technique -- Prognostic Factors -- Success -- Sperm Transport and Storage -- Semen Analysis -- Case Discussion and Presentation -- Case-Based Discussions -- Case 1 -- Case 2 -- Case 3 -- Discussion -- Management -- References -- 15 Establishing and Managing a Sperm Bank -- Introduction -- Donor Sperm Banking -- Anonymous and Known Sperm Donors -- Recruitment, Screening, and Testing of Sperm Donors -- Client Depositor Sperm Banking -- Semen Cryopreservation -- Management and Infrastructure of the Cryobank -- Laboratory Director -- Medical Director -- Tissue Bank Director -- Technical Staff -- Licensing -- Conclusion -- Clinical Vignettes -- References -- 16 Assisted Conception Techniques: Which One to Choose -- Introduction -- Common Andrological Challenges (Semen Parameters) -- Obstructive Azoospermia -- Non-obstructive Azoospermia -- Y-Chromosome Microdeletion -- Common Clinical Challenges -- Coital Disorders -- Varicocele -- Cystic Fibrosis -- Assisted Reproductive Technologies -- Intrauterine Insemination (IUI) -- Sperm Preparation Technique -- Sperm Aspiration Techniques.

Testicular Sperm Extraction (TESE).

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.