Induction and Analysis of Antigen-Specific T Cell Responses in Melonoma Patients and Animal Models.
- 1st ed.
- 1 online resource (149 pages)
Intro -- Contents -- Introduction -- 1: On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients. -- 2: Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201- positive melanoma patients. -- 3: A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression -- 4: Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in non-human primates. -- 5: In vivo antigen stability affects vaccine efficacy -- 6: Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. -- 7: Design and use of conditional MHC class I ligands -- Discussion -- Dutch Summary -- Acknowledgements and Curriculum Vitae.
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Melanoma -- Immunological aspects -- Research. Immunocompetent cells -- Research. T cells -- Research. Cancer vaccines -- Research.