TY  - BOOK
AU  - Piyathilake,David E.
AU  - Liang,Rhong
TI  - Heparin: Properties, Uses and Side Effects
T2  - Pharmacology - Research, Safety Testing and Regulation Biochemistry Research Trends
SN  - 9781621004912
AV  - RM666.H28 -- H47 2012eb 
U1  - 615.7/18 
PY  - 2012///
CY  - Hauppauge
PB  - Nova Science Publishers, Incorporated
KW  - Heparin
KW  - Anticoagulants (Medicine)
KW  - Electronic books
N1  - Intro -- HEPARIN PROPERTIES, USES AND SIDE EFFECTS -- HEPARIN PROPERTIES, USES AND SIDE EFFECTS -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- Contents -- Preface -- Chapter I: The Pharmacology of Oral Heparins -- Abstract -- Introduction -- What Are Heparins? -- The Binding of Heparin to Proteins -- The Interaction of Heparin with Endothelium -- Current and Potential Uses of Heparin -- Oral Heparin -- Antithrombotic Activity Following Oral Heparin Administration -- Other Evidence Indicating the Effectiveness of Orally Administered Heparin and Related Compounds -- Human Studies -- Studies on the Site and Mechanism of Absorption of Oral Heparins -- Conclusion -- References -- Chapter II: Suppression of Membrane Vesiculation: A Possible Anticoagulant, Antimetastatic and Anti-inflammatory Effect of Heparin -- Abstract -- 1. Membrane Budding and Vesiculation -- 2. Clinical Impact of MVs -- 3. Trousseau Syndrome -- 4. Budding and Vesiculation of Phospholipid Vesicles -- 5. Mediated Interaction between Phospholipid Vesicles -- 6. Hypothesis on Anticoagulant, Antimetastatic and Antiinflammatory Effect of Plasma Constituents (Heparin) -- 8. Impact of Autoimmune Antiphospholipid Antibodies and Heparin on Adhesion between Membranes -- Conclusion -- References -- Chapter III: Beyond Anticoagulation:Roles for Heparin in the Vasculature -- Abstract -- Introduction -- The Anti-Proliferative Effects of Heparin -- The Proliferative Effects of Heparin -- The Anti-Inflammatory Effects of Heparin -- Heparin/Heparan Sulfates and Biomaterials -- Conclusion -- Acknowledgements -- References -- Chapter IV: Heparin Monitoring: From Blood Tube to Microfluidic Device -- Abstract -- Introduction -- Unfractionated Heparin -- Low Molecular Weight Heparin -- Thrombotic Disorders and Heparin Treatment -- Heparin Monitoring; Principles of Automated Laboratory Testing for Heparin -- Point of Care Testing -- POC Devices for Heparin Monitoring -- Current Research on POC Devices for Heparin Monitoring -- Conclusion and Future Perspectives -- References -- Chapter V: Advances in the Analysis of the Heparins -- Abstract -- Abbreviations -- Introduction -- Anticoagulant Usage of Heparins -- Diversity of Low Molecular Weight Heparins -- Issues in the Analysis of Heparins -- Nuclear Magnetic Resonance Spectroscopy -- Other Spectroscopic Techniques -- Electrophoresis -- Chromatography -- Conclusion -- Acknowledgements -- References -- Chapter VI: Searching for Heparin Binding Partners -- Abstract -- Introduction -- A Bit of History -- Looking for Identity Patterns -- Searching for Methodological Tools -- Searching for Therapeutic Agents -- Conclusion -- References -- Chapter VII: Heparin-related Nanomaterials -- Abstract -- 1. Introduction -- 2. Heparin as a Component of Nanoparticle-based Delivery Systems -- 3. Heparin as a Drug Delivered by Nano-vehicles -- 4. Conjugation of Heparin with Bio-functional Molecules -- 5. Summary and Perspectives -- References -- Chapter VIII: Pharmacokinetic Differences among Unfractionated Heparin and Low Molecular Weight Heparins: Impact in Patients with Renal Impairment -- Abstract -- Abbreviations -- Introduction -- Prevalence of Renal Failure -- Unfractionated Heparin (UFH) -- Tinzaparin -- Deltaparin -- Enoxaparin -- Fondaparinux -- Dose Reduction versus Therapeutic Outcome -- Discussion -- Conclusion -- References -- Chapter IX: Comprehensive and Updated Study on the Analysis Techniques of Heparin for Human Use -- Abstract -- Abbrevations -- 1. Introduction -- 2. Pharmaceutical Heparin -- 3. Analysis of Pharmaceutical Heparin -- 4. Conclusion -- Acknowledgements -- References; Chapter X: The Elaboration of New Blood Plasma Anticoagulant Complexes of High-molecular-weight Heparin with Glyproline Peptides Main Amino Acids on the Base of Mathematical Simulation of pH-metry Data -- Abstract -- Introduction -- Methods of Investigation -- Experimental -- Results and Discussion -- Conclusion -- References -- Chapter XI: Application of Chemometric Techniques to Heparin Purity Analysis and Quality Control Using Proton NMR Spectral Data -- Abstract -- 1. Introduction -- 2. Basic Principles of Chemometrics -- 3. Data and Methods -- 4. Results and Discussion -- Conclusions -- Appendix: Abbreviations -- Acknowledgment -- References -- Chapter XII: Heparin: The Side Effect of Heparin, Particularly, HeparinInduced Thrombocytopenia -- 1. Introduction -- 2. The Diagnosis of HIT -- 3. The Treatment of the HIT Patients -- 4. The Clinical Management for the HIT Patients -- 5. Conclusion -- References -- Index
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ER  -