TY  - BOOK
AU  - Rossi,Salvatore de
AU  - Bianchi,Filippo
TI  - Aneuploidy: Etiology, Disorders and Risk Factors
T2  - Genetics - Research and Issues
SN  - 9781621002154
AV  - QH461 -- .A54 2012eb 
U1  - 616/.042 
PY  - 2012///
CY  - Hauppauge
PB  - Nova Science Publishers, Incorporated
KW  - Aneuploidy
KW  - Electronic books
N1  - Intro -- ANEUPLOIDY: ETIOLOGY, DISORDERS AND RISK FACTORS -- ANEUPLOIDY: ETIOLOGY, DISORDERS AND RISK FACTORS -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- Contents -- Preface -- Chapter I: Aneuploidy: Mechanisms, Cancer and the Role of  Environmental Pollutants -- Wise Laboratory of Environmental and Genetic Toxicology, -- Maine Center for Toxicology and Environmental Health, University of Southern Maine -- Department of Applied Medical Science, -- University of Southern Maine, Portland, ME, US -- Abstract -- Introduction -- Centrosomes -- Centrosome Duplication Cycle -- Centrosome Amplification and Cancer -- Mechanisms of Centrosome Amplification -- Spindle Assembly Checkpoint -- Mechanism of the Spindle Assembly Checkpoint -- Spindle Assembly Checkpoint Defects and Cancer -- Kinetochores -- Kinetochore Structure and Function -- Kinetochore Dysfunction and Cancer -- Sister Chromatid Cohesion -- Mechanism of Sister Chromatid Cohesion -- Sister Chromatid Cohesion Defects and Cancer -- Hexavalent Chromium: -- An Aneugenic Environmental and  Occupational Carcinogen -- Conclusion -- References -- Chapter II: Ploidy in Mitosis and Meiosis: A Role of MAPK/Erk Network -- EA4479 Laboratoire de Régulation des Signaux de Division University of Lille 1,  Cell Signalomics Group, Parc de la Haute Borne, France -- Abstract -- 1. Crucial to Cell Integrity, Genomic Stability Is Controlled Throughout Cell Cycle -- 1.1. Genomic Stability -- 1.2. Failures in the Mitotic Machinery -- 2. MAPK Network Members Are Involved  in Genomic Stability -- 2.1. MAPK, a Node in a Network for Signal Integration -- 2.2. Requirement for MAPK/Erk in G2/M Progression in -- Mitotic Models -- 2.3. Antagonistic Effects of Erk Pathway: Towards Genomic Integrity -- 3. MAPK Pathway in G2/M, Lessons from Vertebrates Gametes; 3.1. MAPK Activation in the South African Clawed Xenopus Oocytes, a Case of Study for Physical Properties of MAPK Activation -- 3.2. Role of MAPK/Erk Network in Spindle Organization -- 4. Mos, Particularities of a MAPKKK in  Tumor Cells and Gametes -- 4.1. Transformation and Aneuploidy Driven By Mos -- 4.2. Number of M Phases Cycles: Does Mos Rule the Limits? -- Concluding Remarks -- Acknowledgments -- References -- Chapter III: The Spindle Assembly Checkpoint and Aneuploidy -- 1Centro de Investigação em Ciências da Saúde (CICS), Instituto Superior de Ciências da Saúde - Norte, CESPU, Gandra PRD, Portugal -- 2Life and Health Sciences Research Institute (ICVS), Health Sciences School,  University of Minho, Braga, Portugal -- 3Molecular Oncology Research Center, Barretos Cancer Hospital, -- Barretos, São Paulo, Brazil -- 4Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP),  Porto, Portugal -- Abstract -- Introduction -- The Molecular Mechanism of SAC -- SAC Relevance to Aneuploidy and Cancer -- Mouse Models Link SAC Dysfunction,  Aneuploidy and Cancer -- SAC Components and Perspectives  in Anticancer Therapy -- Conclusion -- Acknowledgments -- References -- Chapter IV: The Role of Centromere Cohesion and Associated Proteins in Alzheimer's Disease: A Relation to Aneuploidy? -- 1Institute of Pharmaceutical Research Galenika, Belgrade, Serbia -- 2Department of Pathology, Case Western University, Cleveland, OH, US -- 3 Faculty of Pharmacy, Institute of Physiology, Department of Biology and Human Genetics, University of Belgrade, Belgrade, Serbia -- 4Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences ''Vinca'', University of Belgrade, Belgrade, Serbia -- Abstract -- Introduction -- Alteration of Cohesion and Cohesion Related Proteins in Alzheimers Disease  Lead to Aneuploidy?; Cohesin Associated Proteins and  Chromosome Stability -- CDK 11 A New Cell Cycle Cyclin in Cohesion Dynamics and APP -- Conclusion -- Acknowledgment -- References -- Chapter V: Cohesins, Genomic Stability, and Cancer -- Cell Proliferation and Development Program, Chromosome Dynamics in Meiosis Laboratory. Centro de Investigaciones Biológicas (CSIC), Madrid, Spain -- Summary -- Introduction -- Cohesins, Chromosome -- Instability and Cancer -- Cohesins, DNA-Damage Repair and Cancer -- Cohesins, Chromosome Segregation and Cancer -- Cohesin Complex Subunits -- Cohesin-Regulators: Cohesion Establishment and Maintaining -- Cohesin-Regulators: Cohesion Dissolution -- Concluding Remarks -- Acknowledgments -- References -- Chapter VI: Adult Neurogenesis and Aneuploidy in Etiology, Pathogenesis and Pathology of Alzheimer's Disease -- School of Biotechnology, Dublin City University, -- Glasnevin, Dublin, Ireland -- Abstract -- Introduction -- Amyloid Plaques, Neurofibrillary -- Tangles and Causative Factors of  Alzheimer's Disease -- Aneuploidy in Alzheimer's Disease -- Adult Neurogenesis and Neural Stem Cells -- Neurogenesis and Aneuploid Newly Generated Neuronal Cells in Alzheimer's Disease -- Conclusion and Perspectives -- References -- Chapter VII: Aneuploidy in Cultured Human Multipotent Mesenchymal Stromal Cells -- Research Centre for Medical Genetics,  Russian Academy of Medical Sciences, Russia -- Abstract -- Introduction -- Materials and Methods -- Cell Extraction and Cultivation -- MSCs Characterization -- Cytogenetic Analysis -- Results and Discussion -- Conclusion -- References -- Chapter VIII: Somatic and Germ Cell Spontaneous Aneuploidy Level  in Healthy Fertile People -- Abstract -- Introduction -- Blood Cell Spontaneous Aneuploidy -- Polar Bodies Aneuploidy -- Sperm Aneuploidy -- Aim -- Materials and Methods -- Investigated groups; Karyotyping and Blood Cells Preparation -- Semen Preparation -- Polar Bodies Preparation -- FISH Analysis -- Scoring Criteria of FISH Signals -- Statistical Analysis -- Results and Discussion -- Comparison of Cultivated and Uncultivated Cells as well as Direct and Indirect Labeling -- Sperm and Lymphocyte Aneuploidy in Men -- Polar Body Aneuploidy -- Conclusions -- References -- Chapter IX: Sperm Aneuploidy and Male Fertility -- Abstract -- Estimation of Aneuploidy Frequency  in Spermatozoa -- 1. The Occurrence of Sperm Aneuploidy in Fertile Men is Varying with Male Age, Life Style, and Chemicals Exposure -- 2. The Occurrence of Sperm Aneuploidy in Infertile Men Is Higher than Those of Fertile Men -- 3. Some Chromosomes Showing Higher Incidences of Aneuploidy than the Other Chromosomes -- 4. Sex Chromosomes Showing Higher Incidences of Aneuploidy than the Autosomes and Most of these Errors Ocurrs in Meiosis I -- Chromosomal Abnormalities and Fertility Risk -- Genetic Control of Aneuploidy -- Characteristics of Aneuploid Spermatozoa and New Trends to Overcome Infertility Problem -- Conclusion -- References -- Index
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