TY  - BOOK
AU  - Vinšová,Jarmila
AU  - Krátký,Martin
TI  - Development of New MDR-Tuberculosis Drugs
T2  - Pharmacology - Research, Safety Testing and Regulation
SN  - 9781616684785
AV  - RM409 -- .V56 2010eb 
U1  - 615.5/8 
PY  - 2010///
CY  - Hauppauge
PB  - Nova Science Publishers, Incorporated
KW  - Antitubercular agents
KW  - Multidrug-resistant tuberculosis -- Chemotherapy
KW  - Electronic books
N1  - Intro -- DEVELOPMENT OF NEW  MDR-TUBERCULOSIS DRUGS -- DEVELOPMENT OF NEW  MDR-TUBERCULOSIS DRUGS -- CONTENTS -- PREFACE -- INTRODUCTION -- Chapter 1   RESISTANCE TO COMMONLY USED DRUGS, MECHANISM OF THE ACTION -- ISONIAZID, ETHIONAMIDE -- RIFAMPICIN -- PYRAZINAMIDE -- ETHAMBUTOL -- STREPTOMYCIN -- FLUOROQUINOLONES -- Chapter 2   RESEARCH OF NOVEL MDR-POTENTIAL DRUGS -- 1. STRUCTURE MODIFICATION OF KNOWN COMPOUNDS (INH, ETH, RIF AND RIFAMYCIN DERIVATIVES, PZA, EMB, AND QUINOLONES) -- 2. NEW LEADS WITH NOVEL MECHANISM OF THE ACTION [74] (LINEZOLID, TMC207, PA-824, OPC-67683, BM212, SQ109, FAS20013, LL-3858) -- 3. NOVEL DRUG TARGETS [109] -- 3.1. Cell Wall Biosynthesis -- Cell Wall Structure of M. Tuberculosis [111] -- 3.1.1. Mycolic Acid Synthesis Inhibitors -- Fatty acid biosynthesis [118] -- DesA3 -- 3.1.2. Protein Synthesis Inhibitors [119] -- Inhibition of InhA -- 3.1.3. Polysaccharide Biosynthesis Inhibitors [137] -- Nitrofuranylamides -- 3.2. Targeting P450 Enzymes [148] -- 3.3. Targeting Isocitrate Lyases -- 3.4. FtsZ-Targeting Compounds -- 3.6. Other Targets -- Inhibition of bacterial kinases [164] -- Gyrase Blockers -- Inhibition of Efflux Pumps -- Shikimate Pathway -- Siderophore Biosynthesis -- Biotin Biosynthesis -- Other Potential Targets -- 4. INVESTIGATION OF "NON-ANTI-TUBERCULOUS" DRUGS AND THEIR DERIVATIVES -- 5. OTHER ACTIVE SYNTHETIC COMPOUNDS -- 6. OTHER ACTIVE, NATURALLY-OCCURRING COMPOUNDS -- Chapter 3   CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX
UR  - https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3019875
ER  -