TY  - BOOK
AU  - Perandones,Claudia
AU  - Micheli,Federico Eduardo
AU  - Radrizzani,Martin
TI  - Molecular Mechanisms Involved in the Pathogenesis of Huntington's Disease
T2  - Neurodegenerative Diseases - Laboratory and Clinical Research
SN  - 9781617613524
AV  - RC394.H85 -- P44 2010eb 
U1  - 616.8/51 
PY  - 2010///
CY  - Hauppauge
PB  - Nova Science Publishers, Incorporated
KW  - Huntington''s chorea -- Molecular aspects
KW  - Huntington''s chorea -- Pathogenesis
KW  - Electronic books
N1  - Intro -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Huntington's Disease -- 1.1. Introduction: Unstable Expanding -- Repeats as a Novel Cause of Disease -- 1.2. Common Features of Diseases  due to Unstable Expanding Repeats -- 1.3. Clinical and Genetic Aspects of HD -- 1.4. Epidemiology of HD -- 1.5. Clinical Correlates in HD -- A. Chorea and Motor Impairment -- B. Age at Onset -- C. Rate of Disease Progression -- D. Neuropsychology -- 1. Cognitive Function in HD -- 2. CAG Relationship to Cognition -- E. Clinical Correlates of Mitochondrial Function in HD Muscle -- 1.6. Isolation of the HD Mutation -- 1.7. The HD Trinucleotide Repeat Mutation -- 1.8. Neuropathologic Studies in HD -- Molecular Pathogenesis of Huntington'S Disease -- 2.1. HD Gene and Gene Product -- 2.2. Correlation between Neuropathology  and Pathogenesis in HD -- 2.3. Models for the Pathogenesis of HD -- 2.4. Nuclear Effect of Mutant Huntingtin -- 2.5. Cytoplasmic Effect of Mutant Huntingtin -- A. Axonal Transport in HD -- B. Mitochondrial/Bioenergetic Dysfunction and HD -- Conclusion -- References -- Index
UR  - https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=3018844
ER  -