TY  - BOOK
AU  - Mancini,Leonardo
TI  - Telomeres: Function, Shortening and Lengthening
SN  - 9781608767205
AV  - QH600.3 -- .T456 2009eb 
U1  - 572.8/7 
PY  - 2009///
CY  - New York
PB  - Nova Science Publishers, Incorporated
KW  - Telomere
KW  - Telomerase
KW  - Electronic books
N1  - Intro -- Telomeres: Function, Shortening and Lengthening -- Contents -- Preface -- Telomere Dynamics and Biology in Human Progeroid Syndromes -- Abstract -- 1. Introduction -- 2. Telomere Structure and Biology -- 3. Telomeres in Replicative Senescence and Whole Body Ageing -- 4. Human Progeroid Syndromes -- 5. Progeroid Syndromes Not Associated with Telomere Dysfunction -- Discussion -- Conclusion -- References -- The Role of Telomere-Telomerase System in Age-Related Fitness Decline, a Tameable Process -- Abstract -- Behind the Scenes: Introduction -- The Protagonist: Telomere-Telomerase System -- The Other Protagonist: Programmed Cell Death -- The Main Scene: Cell Turnover -- Two Wrong Performances: Dyskeratosis Congenita and Werner Syndrome -- The Main Action: Aging in Man -- A Badly Interpreted Cue: Telomere-Telomerase System as Oncogenic Factor -- An Equivocal Cue: The Confusion between  Age-Related Fitness Decline in the Wild and Mortality Increase in Laboratory Conditions -- A Surprising Cue:  Animals with Negligible Senescence -- A Poorly Understood Cue: Aging as Distinct Entity -- Ancient and Current Scenery: Toward a Socio-Medical Nightmare -- A Possible Alternative Scenery: Toward the Taming of Senescence -- The Need of a New Dramaturgy: Conclusion -- Acknowledgment -- References -- Cytogenetic Evaluation of Telomere Dysfunction: Chromosomal Aberrations Involving Telomeres and Interstitial Telomeric Sequences -- Abstract -- 1. Introduction -- 2. Cytogenetic Evaluation of Telomere Dysfunction -- Conclusion -- References -- Telomeres - Telomerase Biology and Their Role in Renal and Other Chronic Diseases -- Abstract -- 1. Introduction -- 2. Telomere Biology -- 3. Telomerase -- 4. Alternative Lengthening of Telomeres (ALT) -- 5. Telomeres and Telomerase Status in  Certain Cell Types -- 6. Oxidative Stress; 7. Telomeres and Molecular Senescence -- 8. Telomeres and Ageing -- 9. Telomeres and Disease -- 10. Therapeutics -- Conclusion -- References -- Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis -- Abstract -- Abbreviations -- Introduction -- Telomere and Telomerase in Cancer Development -- Detecting Methods of Human Telomerase/Tert in Clinical Materials of Human Cancers -- Telomerase/Tert for Cancer Diagnosis -- Telomerase/Tert Detection in Clinical Materials -- Conclusion -- References -- Telomeres and Chromosome Segregation -- Abstract -- 1. Introduction -- 2. Telomere-Associated Proteins -- 3. Defective Telomere Structure and Consequences -- 4. Mitotic Chromosome Segregation and Telomeres -- Conclusion -- Acknowledgments -- References -- Telomere-Based Genome-Protective Responses: A Mammalian Improvement on the Bacterial SOS Response? -- Abstract -- Nature's Approach to Genome Protection: The SOS Response -- Evidence for a Telomere-Based Mammalian SOS Response -- Why Base the Mammalian SOS Response in the Telomere? -- Molecular Mechanism of Telomere Sequence-Initiated Signaling -- Harnessing the SOS Response:  Pre-Clinical Experience -- Conclusion -- Conflict of Interest Disclosure -- References -- Telomere Lengthening from Oocyte to Embryonic Stem Cell -- Abstract -- Introduction -- Telomere Lengthening during Gametogenesis -- Telomere Lengthening during Preimplantation Development -- Telomere Length in Cloned and Manipulated Embryos -- Telomere Length in Male and Female Blastocysts -- Telomere Lengthening from Blastocyst to ES Cell -- References -- Transcriptional Activity at the Telomeres of Chironomus (Diptera). Its Possible Role in the Lengthening of the Telomeres -- Abstract -- 1. Introduction -- 2. The Organization of Chironomus Telomeres -- 3. Transcription at Chironomus Telomeres; 4. The Possible Role of Telomeric Transcription in the Elongation Mechanism in Chironomus -- Acknowledgments -- References -- Telomerase Activity: Application to Diagnosis of Human Carcinoma -- Abstract -- Introduction -- Telomerase Activity -- Telomerase Detection Methods -- Telomerase and Cancer -- Conclusion -- References -- Telomere Shortening in Diabetes Mellitus -- Abstract -- Introduction -- Telomere Attrition in Diabetes Mellitus -- Mechanisms Linking Telomere Attrition with Diabetes Mellitus -- Telomere Attrition and Diabetic Complications -- Conclusion -- References -- Do Alterations in the Three-Dimensional Organization of Telomeres Indicate Malignant Transformation? -- Abstract -- The 3D Organization of the Nucleus -- Non-Random Organization of Telomeres in the Nucleus -- Functional Significance of Telomere Organization -- Telomeres and Cancer -- Telomeric Aggregates and Malignant Transformation -- 3D Telomere Organization in Hodgkin and  Reed-Sternberg Cells of Hodgkin's Lymphoma: A Powerful Tool to Advance Knowledge of Lymphoma Biology -- Perspectives -- Acknowledgments -- References -- Telomeres:  Function, Shortening, and Lengthening -- Abstract -- References -- Telomerase Regulation in Stem Cells- How to Flip the Switch? -- References -- Telomere Maintenance Mechanisms in Bone and Soft Tissue Tumors -- Abstract -- Introduction -- ALT Telomere Maintenance Mechanisms in Sarcomas -- Giant Cell Tumor of Bone -- Desmoid Tumor -- Osteosarcoma -- Ewing's Sarcoma -- Chondrosarcoma -- Malignant Fibrous Histiocytoma (MFH) -- Liposarcoma -- Summary and Perspective -- References -- Genetic Polymorphisms of Human Telomerase Reverse Transcriptase (hTERT). Mini Review -- Abstract -- Introduction -- Conclusion -- References -- Genetic Inhibition of Telomere Lengthening in Cancer Prevention and Treatment -- Abstract -- Introduction; Telomerase Inhibition in Cancer Therapy -- Deletion of the Telomerase Genes as a Preemptive Measure against Cancer -- Alternative Functions of Telomerase -- Technical Feasibility of hTERT Gene Targeting -- Replenishment of Stem Cells -- Alternative Lengthening of Telomeres -- Conclusion -- References -- Telomeres: Function, Shortening, and Lengthening -- Abstract -- References -- Clinical Implications of Telomerase Activity in Human Brain Tumors -- Abstract -- Introduction -- Glial Cell Tumors -- Conclusion -- References -- Index
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