Bioencapsulation in Silica-Based Nanoporous Sol-Gel Glasses.
- 1st ed.
- 1 online resource (84 pages)
- Nanotechnology Science and Technology .
- Nanotechnology Science and Technology .
Intro -- BIOENCAPSULATION IN SILICA-BASED NANOPOROUS SOL-GEL GLASSES -- BIOENCAPSULATION IN SILICA-BASED NANOPOROUS SOL-GEL GLASSES -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- CONTENTS -- PREFACE -- ABSTRACT -- Chapter 1 INTRODUCTION -- Chapter 2 BIOENCAPSULATION VIA SOL-GEL PROCESS IN SILICA-BASED MATERIALS: METHOD, MATERIALS, BIOAPPLICATIONS, AND CHARACTERIZATION TECHNIQUES -- 2.1. Protein Bioencapsulation via Sol-Gel Process -- 2.2. Materials and Bioapplications -- 2.3. Probing the Silica-Protein Interactions and Protein-Folding -- 2.3.1. Characterization of the Silica Host Matrix -- 2.3.2. Characterizing the Protein Folding in Nanoporous Sol-Gel Glasses -- Chapter 3 PARAMETERS INFLUENCING THE PROTEIN CONFORMATION IN NANOPOROUS SILICA-BASED SOL-GEL GLASSES -- 3.1. INTRODUCTION TO THERMODYNAMICS- DRIVING FORCES AND INTERACTIONS INFLUENCING THE PROTEIN FOLDING IN SILICA-BASED NANOPOROUS MATERIALS -- 3.2. The Surface Hydration and Hydrophobicity Influence the Protein Folding in Nanoporous Sol-Gel Glasses -- 3.2.1. Hydrophobic Effects on Protein Conformation Induced by Silica Glass Surface Modification with Hydrophobic Organosilanes Precursors -- 3.2.2. Hydrophobic Effects Induced by the Decrease of siloxane -[O-Si-O]- Network Dimension by Glass Surface Modification with Multiple Hydrophobic Alkyl Groups Attached at the Silicon of Organosilane Precursors -- 3.2.3. Solute Effects and Hofmeister Ions Effects -- 3.3. STERIC EFFECTS INDUCED BY THE CHOICE OF CROWDED SILANE MODIFIERS IN TMOS- DERIVED SOL-GEL GLASSES THE HOST MATRIX -- 3.4. INFLUENCE OF THE PORE SIZE, PORE SHAPE AND SURFACE AREA OF THE SILICA-BASED HOST MATRIX ON PROTEIN FOLDING -- 3.5. THERMAL STABILITY OF PROTEINS CONFINED IN THE POROUS HOST MATRIX. Chapter 4 ENHANCING THE PROTEIN FOLDING BY INTRODUCING AND ASSOCIATING HYDROPHOBIC AND STERIC EFFECTS IN MODIFIED SILICA-BASED POROUS GLASSES -- 4.1. INCORPORATING FLUORO-BASED ORGANOSILANES IN TO FORM SUPERHYDROPHOBIC CROWDED ORGANICALLY MODIFIED SILICA BASED HOST MATRICES -- 4.2. INCORPORATING PHOSPHONATE GROUPS IN HYDROPHOBIC SILICA NETWORK -- Chapter 5 EMERGING TECHNIQUES FOR A BETTER UNDERSTANDING OF PROTEIN INTERACTIONS AND CONFORMATIONS IN NANOPOROUS SOL-GEL GLASSES -- 5.1. IN-SITU MAS NMR -- 5.2. FLUORO-RAMAN SPECTROSCOPY -- CONCLUSION -- REFERENCES -- INDEX.