TY  - BOOK
AU  - Kumar,Anoop
TI  - COVID-19: Current Challenges and Future Perspectives
SN  - 9789811498640
AV  - RA644.C67 C685 2021 
U1  - 614.592414 
PY  - 2021///
CY  - Singapore
PB  - Bentham Science Publishers
KW  - COVID-19 (Disease)-Treatment
KW  - Electronic books
N1  - Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- List of Contributors -- Introduction -- Anoop Kumar* -- INTRODUCTION -- STRUCTURE -- TYPES -- Animal Coronaviruses -- Human Coronaviruses -- GLOBAL IMPACT -- DIAGNOSIS -- TREATMENT -- PREVENTION -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- History and Epidemiology of COVID-19 -- Ruchika Sharma* -- INTRODUCTION -- CLASSIFICATION -- EMERGENCE AND SPREADING OF CORONAVIRUSES (TIMELINE) -- EPIDEMIOLOGY -- CORONAVIRUS CASES IN INDIA -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Pathogenesis of COVID-19 -- Saipriyanka Bhimaneni1, Akanksha Verma2 and Anoop Kumar2,* -- INTRODUCTION -- PATHOGENESIS -- Life Cycle of a Virus -- Entry and Replication of the Virus Inside the Host -- Coronavirus Altered Signalling Pathways -- EXTRA-PULMONARY MECHANISM -- CLINICAL MANIFESTATIONS -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Diagnosis, Treatment and Management of COVID-19 -- Vipin Bhati1, Sheetal Yadav2 and Anoop Kumar3,* -- INTRODUCTION -- DIAGNOSTIC APPROACHES -- Physical Symptoms -- Laboratory Tests: Sample Intake Methods, Analysis -- Molecular Tests (Antigen) -- Serology -- Hematological Examination -- IMAGING -- Chest X-ray Examination -- Chest Computed Tomography -- Lung Ultrasound -- FELUDA Paper Strip Test -- Treatment, Management and Prevention -- Asymptomatic and Non-serious Cases -- Mild to Moderate Cases -- Serious Cases -- Preventive Measures Public -- POST COVID-19 INFECTION TREATMENT -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Convalescent Plasma for Treatment of COVID-19 Infection; Rahul Shukla*, Reddy Gayathri Aparnasai and Mayank Handa -- INTRODUCTION -- TREATMENT OPTIONS EXPLORED TILL DATE -- Historical Background of Passive Antibody Therapy -- Toxin Neutralization -- CONVALESCENT PLASMA-BASED THERAPEUTICS AGAINST COVID-19 -- Challenges -- Ethical Constraint -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Effect of Early Lockdown in India During the Outbreak of COVID-19: A Comparative Study of USA, Italy and India -- Gagandeep Maan, Navyashree V. Gowda, Anoop Kumar and Awanish Mishra* -- INTRODUCTION -- PROGRESSION OF THE DISEASE -- SIGNIFICANCE OF LOCKDOWN -- IMPACT OF DIAGNOSIS -- DEMOGRAPHIC DISTRIBUTION -- CONCLUSION AND FUTURE PERSPECTIVES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- COVID-19 Altered Immune Signalling Pathways -- Shashikanta Sau and Anoop Kumar* -- INTRODUCTION -- COVID-19 ALTERED INNATE IMMUNE RESPONSE SIGNALLING PATHWAYS -- Effects on Macrophages -- Effects on TLR Signalling Pathways -- MyD88 Dependent Signalling -- MyD88 Independent Signalling -- COVID-19 Altered the Connection Between the Innate and Adaptive Immune System -- COVID-19 Altered Humoral Response Pathways -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- COVID-19 Altered Brain Signalling Pathways -- Urvashi Langeh1, Tania Bajaj2, Priyanka Bajaj3, Swati Kaushal1, Diksha Saluja1, Shelly Agarwal1, Neelam Sharma1, Bharti Verma1, Meena Yadav1, Rima Singh1, Charan Singh2 and Arti Singh1,* -- INTRODUCTION -- NEUROPATHOLOGY OF COVID-19 -- Direct Pathway -- a. Blood Circulation Pathway -- b. Neuronal Pathway -- Hypoxic Brain Injury -- IMMUNE SYSTEM -- ANGIOTENSIN-CONVERTING ENZYME-2 (ACE-2) -- VARIOUS NEUROLOGICAL DISORDER REPORTED TO BE ASSOCIATED WITH COVID-19 -- Cerebrovascular Complications; Encephalopathy -- Viral Encephalitis -- ROLE OF BRAIN SIGNALLING PATHWAYS IN MANIFESTATION OF COVID-19 -- Interferon Signalling Pathway -- Mitogen-activated Protein Kinase (MAPK) Pathway -- JAK/STAT Pathway -- ACE-2/ANG-(1-7)/MAS Signalling Pathway -- Unfolded Protein Response (UPR) and Autophagy Pathways -- MAJOR COMPONENTS OF NERVOUS SYSTEM INVOLVED IN COVID-19 -- Neurons -- Movement Disorders in the World of COVID-19 -- Nervous System Involvement after Infection with COVID-19 -- Multidisciplinary Research Priorities for the COVID-19 Pandemic: A Call for Action for Mental Health Science -- Lack of Dyspnea in COVID-19 Patients -- Neuroinfection May Potentially Contribute to the Pathophysiology and Clinical Manifestations of COVID-19 -- Neurological Manifestations in COVID-19 Caused by SARS-CoV-2 -- ACE- 2 -- Organ-Protective Effect of ACE- 2 and its Effect on the Prognosis of COVID-19 -- COVID-19 and ACE Inhibitors and Angiotensin Receptor Blockers (ARBs) -- Renin-Angiotensin-Aldosterone System Inhibitors in Patients with COVID-19 -- Mitochondria of Brain Cells -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Risk Factors and Complications Associated with COVID-19 -- Gagandeep Maan and Awanish Mishra* -- INTRODUCTION -- POSSIBLE RISK FACTORS FOR SUSCEPTIBILITY OF COVID-19 -- Age -- Gender and Sex -- Medical Conditions -- Hypertension -- Diabetes Mellitus -- Cardiovascular Disorders -- Pregnancy -- Lifestyle Issues -- Smoking -- Crowding -- Occupation -- COVID-19 ASSOCIATED COMPLICATIONS -- Pneumonia and Respiratory Complications/Failure -- Nephritis and Acute Renal Failure -- Myocarditis and Cardiac Failure -- Hepatic Malfunctions/Failure -- CONCLUSION AND FUTURE PERSPECTIVES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES; Possible Mechanism of Deaths Due to COVID-19 -- Aakriti Garg1 and Anoop Kumar2,* -- INTRODUCTION -- DISTRIBUTION OF DEATH CASES DUE TO COVID-19 -- POSSIBLE MECHANISM OF DEATHS WITHOUT TREATMENT -- POSSIBLE MECHANISM OF DEATHS DURING TREATMENT -- Patients with Pre-existing Medical Conditions -- Patients without Any History of Pre-existing Medical Conditions -- ROLE OF CONCOMITANT MEDICATIONS AND POSSIBLE MECHANISM OF DEATHS -- MEASURES TO MINIMIZE DEATH DUE TO COVID-19 -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Possible Targets of SARS-CoV-2 -- Navyashree V. Gowda and Anoop Kumar* -- INTRODUCTION -- POTENTIAL DRUG TARGETS -- Potential SARS-CoV-2 Targets -- Blocking Critical Viral Proteins -- Potential Targets Inhibiting the Self-Assembly Process -- Potential Human Cell Targets -- Targeting of Virulence Factor -- Targeting of Host-specific Receptor or Enzymes -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Repurposing of Drugs for COVID-19 Infections -- Aakriti Garg1 and Anoop Kumar2,* -- INTRODUCTION -- REPURPOSING OF DRUGS AGAINST SARS-COV-2 -- Chloroquine and Hydroxychloroquine -- Lopinavir/Ritonavir -- Ribavirin -- Umifenovir -- ACE Inhibitors and Angiotensin Inhibitors -- Remdesivir -- Favipiravir -- Corticosteroids -- Anti-cytokines or Immunomodulatory Agents -- Rapamycin -- Ivermectin -- Camostat and Nafamostat -- CURRENT CHALLENGES AND FUTURE PERSPECTIVES -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Herbals for COVID-19 Infection -- Amit Gupta1, Vipin Bhati2 and Anoop Kumar1,* -- INTRODUCTION -- HERBALS AGAINST SEVERE ACUTE RESPIRATORY SYNDROME (SARS) -- In-Silico Studies -- In-Vitro Studies -- In Vivo Studies -- HERBALS AGAINST MIDDLE EAST RESPIRATORY SYNDROME (MERS); In-Silico Studies -- In-Vitro Studies -- In-Vivo Studies -- HERBALS AGAINST COVID-19 -- In-Silico Studies -- In-Vitro Studies -- POSSIBLE ANTIVIRAL MECHANISM OF HERBALS AGAINST SARS, MERS, AND COVID-19 -- Possible Mechanism of Herbals Against SARS -- Possible Mechanism of Herbals Against MERS -- Possible Mechanism of Herbals Against COVID-19 -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Current Challenges and Future Prospects of COVID-19 -- Ruchika Sharma* -- INTRODUCTION -- FORTHCOMING CHALLENGES AGAINST COVID-19 -- CONCLUSION AND PERSPECTIVE -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Subject Index -- Back Cover
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