Personalized Immunotherapy for Tumor Diseases and Beyond.
- 1st ed.
- 1 online resource (283 pages)
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- REFERENCES -- List of Contributors -- INTRODUCTION -- MHC and Cancer Immunotherapy -- Li-Hua Jiang1,* and Wei-Hua Yan2 -- OVERVIEW OF MHC GENES AND MOLECULES -- 1. Characteristics of the HLA Gene Complex -- 2. HLA Molecule Structure -- 3. Distribution and Function of HLA Molecules -- 4. MHC Allele Detection -- MHC CLASS I MOLECULAR LOSS AND CANCER IMMUNOTHERAPY -- 1. Loss of Class I HLA Expression in Tumor Tissues -- 2. Types of Class I HLA Deletion. -- 3. Expression of Class I HLA Molecules and Efficiency of Immunotherapy -- 4. The Relation Between Selective Pressure of Immunocyte and Changes of Class-I HLA Expression Pattern in Tumor Cells -- EXPRESSION LEVELS OF NONCLASSICAL MHC CLASS I AND TUMOR IMMUNE ESCAPE -- 1. The HLA Class I Antigen Expression and Cancer -- 2. Roles of HLA Ib Antigens in Immune Modulation -- 3. Clinical Relevance of HLA Ib Expression in Cancers -- 4. Prospective of HLA-E and HLA-G Targeted Cancer Immunotherapy -- MHC FOR T-CELL EPITOPE AND ACTIVE IMMUNE VACCINES -- MHC FOR ADOPTIVE IMMUNE CELL THERAPY -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immune Cells Signaling-Pathway and Genomic Profiles for Personalized Immunotherapy -- Wei Zhang1, Yan Qu1, Meihua Lin1, Amit Datta1, George E. Liu1,2 and Biaoru Li1,3,* -- INTRODUCTION -- T-CELL MEMBRANE SIGNALING -- T-CELLS PATHWAY AND NETWORKS -- GENOMIC EXPRESSION PROFILE OF T-CELLS -- 1. Genomic Expression Profiles of TIL -- 2. Genomic Expression Profiles from Peripheral Blood Immune Cells -- GENOMIC EXPRESSION PROFILE OF B-CELL -- 1. Genomic Expression Profiles of B-Lymphocyte -- 2. Network of B-lymphocyte -- GENOMIC EXPRESSION PROFILE AND NETWORK OF NK-CELL -- 1. NK-Lymphocyte -- 2. Genomic Expression Profiles of NK-Lymphocyte. 3. Network of NK-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF NKT-CELL -- 1. NKT-Lymphocyte -- 2. Genomic Expression Profiles and Network of NKT-Lymphocyte -- GENOMIC EXPRESSION PROFILE OF MACROPHAGE -- 1. Macrophage -- 2. Genomic Expression Profiles and Network of Macrophages -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Immunoassay of Personalized Immunotherapy -- Li-Hua Jiang1 and Biaoru Li1,2,* -- INTRODUCTION -- BASIC RECORD OF IMMUNE FUNCTION AND RESPONSE -- Delayed-Type Hypersensitivity In Vivo -- Measures of Immune Function Ex Vivo -- 1. Detection of T-cell Number with Intracellular Cytokines by Flow Cytometry -- 2. Detection of Secreted Cytokines by ELISA Assays -- 3. Lymphoproliferation Assay -- 4. CTL and Quantifying CTL -- Measures of Antigen-Specific Immune Responses In Vitro/Ex Vivo -- 1. Peptide MHC Tetramers -- 2. TCR Complementarity Determining Region -- Measurement of Cytokine mRNA -- Measurement of Tumor Antibodies -- MEASUREMENT OF IMMUNE TARGETS FOR IMMUNOTHERAPY -- Measuring Inhibitory and Activating Receptors by IHC Staining -- Measurement of mRNA and SNPs in Inhibitory and Activating Receptor -- Measuring Inhibitory Receptors by ELISA or FACS at the Cell Level -- 1. Detection of Inhibitory Receptors by Flow Cytometry -- 2. Detection of Inhibitory Receptors by ELISA Assays -- TECHNICAL CONSIDERATION AND STANDARDIZATION -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Tumor Microenvironment, ADO/IDO Pathway-Foundation of Personalized Immunotherapy -- Xiao Zhu1, LiHua Jiang2 and Biaoru Li2,3,* -- INTRODUCTION -- EXTRACELLULAR MATRIX WITH NETWORK -- REGULATING CELLS -- 1. Tumor-Associated Macrophages -- 2. Neutrophils -- 3. Tumor-Infiltrating Lymphocytes -- 4. Carcinoma Associated Fibroblasts. Myeloid-Derived Suppressor Cells (MDSC) -- REGULATING MOLECULES -- 1. ADO Regulating Pathways -- 2. IDO Regulating Pathways -- THERAPEUTIC TARGETS WITH THEIR AGENTS -- 1. Therapies Antibodies and Kinase Inhibitors -- 2. Therapeutic Targets of ADO Pathway -- 3. Therapeutic Targets of IDO Pathway -- 4. Other Ways of TME Therapy -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Molecular Targeting Checkpoint in Cancer-Foundation of Personalized Immunotherapy -- Shuzhen Tan1 and Xiao Zhu2,* -- INTRODUCTION -- MOLECULAR TARGETING CHECKPOINT INHIBITORS -- PD-1/PD-L1 -- CTLA-4 -- TIM-3 -- LAG-3 -- Siglec-15 -- APPLICATION OF MOLECULAR TARGETING CHECKPOINT INHIBITORS -- Small Cell Lung Cancer -- Non-Small Cell Lung Cancer (NSCLC) -- Hepatocellular Carcinoma (HCC) (for PDL1) -- Melanoma -- Kidney Cancer -- PROBLEM -- CONCLUSION AND PERSPECTIVE -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Molecular Screening and Neoantigen Cloning-Fundamental of Adoptive T-cell Immunotherapy -- Wei Zhang1, George Liu1, Emmanuelle Devemy2 and Biaoru Li1,2,3 -- INTRODUCTION -- MOLECULAR SCREENING NEOANTIGEN AND MUTANTS -- 1. Phage Display Screen System -- 2. scFv Screening -- 3. TCR Screening -- 4. Yeast Two-Hybrid Screening -- 5. Molecular Technique Supporting Genomics and Bioinformatics -- 6. Other Screenings of Molecular Biology -- MOLECULAR CONSTRUCTS -- 1. CAR Design and Constructs -- 2. Specific TCR Design -- 3. Specific T-cell and Constructs -- VECTOR SELECTION FOR GENE PACKAGE AND DELIVERY -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Primary Cell Culture and T-cell Cloning -Fundamental of Adoptive T-cell Immunotherapy -- Biaoru Li1,2,3,*, Supriya Perabekam2, Alan Larson2 and Hong-Liang Hu1 -- INTRODUCTION. PERSONALIZED MUILTIPLE DIMENSIONAL CULTURE SYSTEM -- 1. 2-D Primary Cell Culture -- 2. Humanized Animal Model by Primary Tumor Cells -- 3. Basic 3-D Primary Tumor Cell Culture -- 4. 3-D Bio-printing Primary Tumor Cell and Tissue Culture -- 5. Multiple D Primary Tumor Cell Culture -- T-CELL CLONING WITH CULTURE -- 1. TIL Culture with TIL Polyclonal Strategy and Techniques -- 2. Specific Peptides Pulsed Dendritic Cells (DC) Co-Culture CD8+Cell with CTL Cell Cloning and Culture -- 3. Shared Antigen CAR and TCR T-cell Construct with Cloning Culture -- 4. Genomic Supporting Patient's Neoantigen-Specific CAR T-cell and TCR T-cell Construction with their Cloning Culture -- 5. Genomic Supporting Functional TIL with their Polyclonal Cultures -- CYTOKINES OF SPECIFIC T-CELL THERAPY -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Bioinformatics of T-cell and Primary Tumor Cells-Fundamental of Adoptive T-cell Immunotherapy -- George Liu1,2, Jie Zheng3 and Biaoru Li1,4,* -- INTRODUCTION -- WORKFLOW OF TUMOR SAMPLING WITH SNP AND GENOMIC ANALYSIS -- 1. Clinical Tumor Sampling to the Isolation of Tumor Cells and TIL -- TUMOR GWAS AND GENOMIC PROFILE WITH ANALYSIS -- 1. SNP Detection and Analysis -- 2. Detection of Genomic Expression -- SYSTEM MODELING FOR TUMOR CELLS AND TILS -- 1. System Modeling of a Network to Discover GES -- 2. GES Determining Targets -- NEOANTIGEN ANALYSIS AND DETERMINATION -- BIOIFNROAMTICS INTEGRATION FOR T-CELL TARGETS -- SUCCESSFUL SYSTEM BIOLOGY INTEGRATION FOR FUNCTIONAL POLYCLONAL TIL TARGETS -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Development of Adoptive T-cell Immunotherapy-Future of Personalized Immunotherapy -- Biaoru Li1,2,*, Shanqing Tong2, Xihan Zhang2, Youming Zhu2, Baoyu Wu2 and Deyuan Lu2 -- INTRODUCTION. HISTORY AND DEVELOPMENT OF IMMUNE THERAPY -- 1. Development of TIL Culture Procedures for Clinical Application -- 2. Development of TILs Clinical Application -- 3. TILs Clinical Location Administration -- 4. Immune Cell Therapy Beyond TILs -- Development and Application of NK cells -- 5. Development of NK Cells Culture -- 6. Development of a Clinical Application for NK Immunotherapy -- 7. Research and Development of Autologous Lymphocytes -- CURRENT CONSIDERATION AFTER COMPLETION OF CLINICAL TRIALS -- FUTURE OF ADOPTIVE T-CELL IMMUNOTHERAPY -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Gene Therapy and Genomic Editing-Development of Adoptive T-cell Immunotherapy -- JianQing Ding1, GuanXiang Qian2, Shishu Chen2 and Biaoru Li1,* -- INTRODUCTION -- DEVELOPMENT OF VECTORS OF CLINICAL GENE THERAPY -- BACKGROUND OF GENE EDITING FOR ADOPTIVE T-CELL IMMUNOTHERAPY -- APPLICATION OF GENE EDITING FOR T-CELL IMMUNOTHERAPY -- 1. Gene Editing of T-cells as a Universal Donor -- 2. Biomarker Depletion of Allogeneic Stem Cell to Support CAR-T Biomarker of Non-Specific Targets -- 3. Depletion of Immunosuppression for T-cell Function -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Genetically Modified T-cells Affinity to Tumor Cells-Development of Adoptive T-cell Immunotherapy -- Shen Li1, Supriya Perabekam2, Emmanuelle Devemy2 and Biaoru Li2,3,* -- INTRODUCTION -- HISTORY AND DEVELOPMENT OF TCR AND CAR IMMUNE THERAPY -- GENERATION OF CLINICALLY EFFECTIVE TCR T-CELL AND CAR T-CELLS -- CLINICAL TRIALS OF TCR T-CELL AND CAR T-CELL -- COMPANY PRODUCTS OF CAR T-CELL AND TCR T-CELL -- FUTURE OF CAR T-CELL AND TCR T-CELL -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES. System Modeling of T-cell Function-Development of Adoptive T-cell Immunotherapy.