TY  - BOOK
AU  - Remaut,Han
AU  - Fronzes,Remi
TI  - Bacterial Membranes: Structural and Molecular Biology
SN  - 9781908230911
AV  - QR77.3 .B2965 2014 
U1  - 589.90875 
PY  - 2014///
CY  - Norfolk
PB  - Caister Academic Press
KW  - Bacterial cell walls
KW  - Bacteria-Physiology
KW  - Electronic books
N1  - Intro -- Contents -- Contributors -- Preface -- Part I: Membrane Composition and Synthesis -- 1: Bacterial Cell Wall Growth, Shape and Division -- Introduction -- Peptidoglycan structure and architecture -- Peptidoglycan synthesis -- PG hydrolases -- Cell division -- Growth with different cell shapes -- Antibiotic inhibition of peptidoglycan growth and cell division -- Future trends -- 2: The Outer Membrane of Gram-negative Bacteria: Lipopolysaccharide Biogenesis and Transport -- An overview of OM structure, functions and evolution -- Lipopolysaccharide structure and biosynthesis -- LPS transport to the outer membrane -- Conclusions and future trends -- 3: Outer Membrane Protein Biosynthesis -- Introduction -- Outer membrane proteins (OMPs) -- General overview of OMP biosynthesis -- In vitro studies of OMP folding and membrane insertion -- Assisted folding of OMPs in vivo by the BAM complex -- The components of the BAM complex -- Structural studies of the BAM complex -- Proposed BAM mechanisms -- Eukaryotic homologues -- Discussion -- Future trends -- 4: Bacterial Lipoproteins: Biogenesis, Virulence/Pathogenicity and Trafficking -- Introduction -- Lipoproteins in Gram-negative diderm bacteria -- Lipoproteins in Gram-positive diderm bacteria -- Lipoproteins in Gram-positive monoderm bacteria -- Problems to be answered -- 5: The Fascinating Coat Surrounding Mycobacteria -- Introduction -- Architecture of the mycobacterial cell envelope -- The plasma membrane -- The periplasm -- Cell wall -- The capsule -- Concluding remarks -- Part II: Protein-Lipid Interactions -- 6: The Role of Lipid Composition on Bacterial Membrane Protein Conformation and Function -- Introduction -- Composition and structure of bacterial membranes -- Co-crystallized lipids: intimate and functional -- MFS transporters: the role of PE -- Lipids and protein folding; Simulations: towards a molecular understanding -- Lipid-protein interactions and crystallization of membrane proteins -- Conclusions -- Part III: Transport Across Bacterial Membranes -- 7: Bacterial ABC Transporters: Structure and Function -- Introduction -- Origins, phylogeny and diversity -- Structure of bacterial ABC transporters -- The unified model of translocation across membranes -- 8: Energy-coupled Transport Across the Outer Membrane of Gram-negative Bacteria -- Introduction -- Structure and function of the TonB-ExbB-ExbD protein complex -- Well-studied examples of energy-coupled substrate transport across the OM -- Energy-coupled OM proteins as signalling molecules: transcription initiation from the cell envelope (transenvelope signalling) -- In vivo reconstitution of active transport proteins from plugs and β-barrels -- In vitro reconstitution of energy-coupled transporters in planar lipid bilayer membranes -- OM transporters as colicin receptors -- Outlook -- 9: The Permeability Barrier: Passive and Active Drug Passage Across Membranes -- Introduction -- Lipid-drug interactions -- Translocation across liposomes -- Permeation revealed by electrophysiology -- Translocation through a channel: limiting factors -- Antibiotic transport across membranes -- Conclusions -- 10: Targeting and Integration of Bacterial Membrane Proteins -- Introduction -- How are substrates selected for the SRP- or SecA-pathway? -- Co-translational targeting of inner membrane proteins by the SRP-system -- Post-translational targeting of outer membrane proteins by the SecA/SecB system -- The SecYEG translocon constitutes the major protein conducting channel in bacteria -- YidC forms a SecYEG-independent integration site for some membrane proteins -- Subcellular localization of the protein transport machinery -- Conclusions and future trends; 11: Envelope-spanning Secretion Systems in Gram-negative Bacteria -- Introduction: bacterial secretion systems -- The type III secretion system -- The type IV secretion system -- Prospects -- Part IV: Signal Transduction Across Bacterial Membranes -- 12: Signalling Mechanisms in Prokaryotes -- Introduction -- Two-component systems -- Eukaryotic-like Ser/Thr/Tyr protein kinases and phosphatases -- Concluding remarks -- Part V: Bacterial Membranes in Pathogenesis -- 13: Outer Membrane-embedded and -associated Proteins and their Role in Adhesion and Pathogenesis -- Introduction -- Pili -- Type V secreted proteins -- Cell-surface exposed lipoproteins -- Integral OMPs -- Conclusions and future prospects -- 14: Bacterial Membranes as Drug Targets -- Introduction -- Perturbing membrane synthesis and physiology -- Hijacking bacterial import systems -- Jamming signal transduction -- Blocking the secretion pathways -- Concluding remarks -- Index
N2  - Written by specialists in the field, this book provides a comprehensive overview of the structural and molecular biology of cellular processes that occur at or near bacterial membranes. The authors present and discuss recent progress on the function and involvement of membranes in bacterial physiology enabling a greater understanding of the molecular details of the cell envelope, its biogenesis and function. Topics covered include: cell wall growth, shape and division, the outer membrane of Gram-negative bacteria, outer membrane protein biosynthesis, bacterial lipoproteins, mycobacteria, lipid composition, ABC transporters, transport across the outer membrane, drug passage across membranes, bacterial membrane proteins, secretion systems, signal transduction, signalling mechanisms, bacterial membranes in adhesion and pathogenesis, and membranes as a drug target. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries
UR  - https://ebookcentral.proquest.com/lib/orpp/detail.action?docID=5897811
ER  -