Metallo-Drugs : Development and Action of Anticancer Agents.
- 1st ed.
- 1 online resource (588 pages)
- Metal Ions in Life Sciences Series ; v.18 .
- Metal Ions in Life Sciences Series .
Intro -- About the Editors -- Historical Development and Perspectives of the Series -- Preface to Volume 18 -- Contents -- Contributors to Volume 18 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions -- 2. Polynuclear Platinum Complexes. Structural Diversity and DNA Binding -- 3. Platinum(IV) Prodrugs -- 4. Metalloglycomics -- 5. The Deceptively Similar Ruthenium(III) Drug Candidates KP1019 and NAMI-A Have Different Actions. What Did We Learn in the Past 30 Years? -- 6. Multinuclear Organometallic Ruthenium-Arene Complexes for Cancer Therapy -- 7. Medicinal Chemistry of Gold Anticancer Metallodrugs -- 8. Coordination Complexes of Titanium(IV) for Anticancer Therapy -- 9. Health Benefits of Vanadium and Its Potential as an Anticancer Agent -- 10 Gallium Complexes as Anticancer Drugs -- 11. Non-covalent Metallo-Drugs: Using Shape to Target DNA and RNA Junctions and Other Nucleic Acid Structures -- 12. Nucleic Acid Quadruplexes and Metallo-Drugs -- 13. Antitumor Metallodrugs that Target Proteins -- 14. Metallointercalators and Metalloinsertors: Structural Requirements for DNA Recognition and Anticancer Activity -- 15. Iron and Its Role in Cancer Defense: A Double-Edged Sword -- 16. Copper Complexes in Cancer Therapy -- 17. Targeting Zinc(II) Signalling to Prevent Cancer -- Subject Index.
Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.