Frontiers in Clinical Drug Research - Alzheimer Disorders Volume 6.
- 1st ed.
- 1 online resource (207 pages)
- Frontiers in Clinical Drug Research - Alzheimer Disorders ; v.6 .
- Frontiers in Clinical Drug Research - Alzheimer Disorders .
Intro -- CONTENTS -- PREFACE -- List of Contributors -- The Treatment of Brain Inflammation in Alzheimer's Disease. Can Traditional Medicines Help? -- James David Adams* -- INTRODUCTION -- Anti-inflammatory Agents in AD -- Risk Factors for Developing AD -- Prevention of AD -- Ceramide and AD -- The Blood Brain Barrier and AD -- Visfatin and AD -- Traditional Plant Medicines for AD -- The Modern Approach to Curing AD -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Stem Cell Strategies for the Modeling and Therapy of Alzheimer's Disease -- Haigang Gu* -- 1. INTRODUCTION -- 2. NEUROPATHOLOGY OF AD: KEYS TO DRUG DISCOVERY AND ANIMAL MODELS -- The β-amyloid Hypothesis of AD -- The Hyper-phosphorylated Tau Protein Hypothesis of AD -- The cholinergic hypothesis of AD -- 2.1. Drug Discovery of AD -- 2.1.1. Treatment of Amyloid Pathology -- 2.1.2. Treatment of Tau Pathology -- 2.1.3. Treatment of Synaptic Dysfunction -- 2.1.4. Neurotrophic Factors (NTFs) -- 2.1.5. Cell Transplantation -- 2.2. Animal Models of AD -- 2.2.1. Transgenic Animal Models of AD -- 2.2.2. Selective Cholinergic Lesion Animal Models of AD -- 3. STEM CELLS AS USEFUL TOOLS FOR CELL TRANSPLANTATION, DRUG DISCOVERY AND AD MODELING -- 3.1. Neural Stem/Progenitor Cells (NP/SCs) -- 3.2. Mesenchymal Stem Cells (MSCs) -- 3.3. Embryonic Stem Cells (ESCs) -- 3.4. Induced Pluripotent Stem Cells (IPSCs) -- 3.5. In Situ Generation of Neurons in the Brain -- 3.6. Modeling and Therapy of AD with Genome Editing -- 4. PERSPECTIVES -- ABBREVIATIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Retinal Neurodegeneration in Alzheimer's Disease -- L. Guo1, M. Pahlitzsch#, 1, F. Javaid#, 1 and M.F. Cordeiro*, 1, 2 -- INTRODUCTION -- THE RETINA - AN INTEGRAL PART OF THE BRAIN -- VISUAL CHANGES IN AD -- Visual Abnormalities -- Pupil Abnormalities. RETINAL CHANGES IN AD -- Retinal Histopathologic Abnormalities -- Retinal in vivo Abnormalities -- Retinal Nerve Abnormalities -- Retinal Vasculature Abnormalities -- Retinal Cellular Abnormalities - RGC Apoptosis -- NON-RETINAL OCULAR CHANGES IN AD -- AD-RELATED CHANGES IN RETINAL DISEASES -- AD-related Changes in Glaucoma -- AD-related Changes in AMD -- TARGETING OF AMYLOID-ß IN TREATMENT OF GLAUCOMA AND AMD -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Pathophysiology of Alzheimer Disease: Current Drug Therapy -- Sumeet Gupta* and Vikas Jhawat -- INTRODUCTION -- PATHOPHYSIOLOGY OF ALZHEIMER'S DISEASE -- HYPERTENSION AND ALZHEIMER'S DISEASE -- ROLE OF RENIN ANGIOTENSIN SYSTEM (RAS) IN ALZHEIMER'S DISEASE -- GENETIC POLYMORPHISM AND AD -- TREATMENTS FOR ALZHEIMER'S DISEASE -- HERBAL DRUGS FOR THE TREATMENT OF AD -- CONCLUSION -- ABBREVIATIONS: -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Biological Mass Spectrometry for Diagnosis of Alzheimer's Disease -- Hani Nasser Abdelhamid2,* and Hui-Fen Wu1,3,4,5,* -- INTRODUCTION -- Requirements of Alzheimer's Disease Diagnosis -- Application of Mass Spectrometry for Alzheimer's Disease -- Imaging Mass Spectrometry for Alzheimer's Disease -- Advantages and disadvantages of Mass Spectrometry -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Structure-Activity Relationship of Melanin as a Source of Energy Defines the Role of Glucose to Biomass Supply Only, Implications in the Context of the Failing Brain -- Arturo Solís Herrera* -- INTRODUCTION -- Basal Brain Energy Metabolism -- The Role of Pyridine Nucleotides and the Abnormal Expression of Genes -- REMARKS AND CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES. Neuro-protective Properties of the Fungus Isaria japonica: Evidence from a Mouse Model of Aged-related Degeneration -- Koichi Suzuki1,*, Masaaki Tsushima1, Masanobu Goryo2, Tetsuro Shinada3, Yoko Yasuno3, Eiji Nishimura3, Yasuo Terayama4, Yuki Mori5 and Yoshichika Yoshioka5 -- INTRODUCTION -- IJE Improves Nerve Function in Aged Mouse Brain -- 1. Neuroprotective Effects of IJE -- 2. Histochemical Observation -- 3. Assessments of Acute and Sub-acute Toxicity -- NMR Analyses in the I. Japonica Extract -- 1. Chemical Component of I. Japonica -- 2. Biologically Active Substances -- 3. NMR and Mass Study of Water Extract of I. Japonica -- Visualization of the Physiological and Pathological Alterations in the Central Nervous System using MRI and MRS -- 1. Fine Imaging Using Ultra-high Field MRI -- 2. Magnetic Resonance Spectroscopy -- 3. Brain Temperature Estimation Using MRS -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX.