TY  - BOOK
AU  - Atta-ur-Rahman
TI  - Advances in Cancer Drug Targets
T2  - Advances in Cancer Drug Targets
SN  - 9781681082332
AV  - RC271.C5 -- .A383 2016eb 
U1  - 616.99406099999999 
PY  - 2016///
CY  - Sharjah
PB  - Bentham Science Publishers
KW  - Cancer--Chemotherapy
KW  - Electronic books
N1  - Intro -- CONTENTS -- PREFACE -- List of Contributors -- Neutrophil Elastase as a Target in Lung Cancer: the State of the Art -- 1. INTRODUCTION: NEUTROPHIL ELASTASE/Α-1ANTITRYPSIN IMBALANCE AS A LINK BETWEEN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND LUNG CANCER -- 2. MULTIFACETED FUNCTIONS OF NEUTROPHIL ELASTASE IN LUNG CANCER -- 3. ENDEGNENOUS NEUTROPHIL ELASTASE INHIBITORS -- 3.1. Proteinaceous Inhibitors -- 3.2. Natural Compounds -- 3.2.1. Glycosaminoglycans -- 3.2.2. Phenolics -- 3.2.3. Triterpenoids -- 3.2.4. Fatty Acids and Peptide Derivatives -- 4. DESIGN OF DUAL NEUTROPHIL ELASTASE / MMP INHIBITORS -- DESIGN OF DUAL HNE-MMP INHIBITORS -- CONCLUDING REMARKS -- ADDITIONAL MATERIAL -- 1. Molecular Modeling and Molecular Graphics -- 2. Ligand and Receptor Preparation -- 3. Docking Protocol -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGEMENTS -- ABBREVIATIONS -- REFERENCES -- Inhibition of Membrane Complement Inhibitor Expression (CD46, CD55, CD59) by siRNA Sensitizes Tumor Cells to Complement Attack -- INTRODUCTION -- MATERIALS AND METHODS -- Cell Culture -- SiRNA Sequences -- SiRNA Transfection -- Flow Cytometry -- Complement-mediated Cytotoxicity Assay (CDC) -- C3-binding Studies -- Real-Time RT-PCR -- Statistical Analysis -- RESULTS -- Design of siRNAs Specific for CD46, CD55 and CD59 -- SiRNA-mediated Downregulation of mCRP Expression -- siRNA-mediated Augmentation of Tumor Cell Complement Lysis and Opsonization -- Time-course of siRNA-induced mCRP Inhibition -- Stable Downregulation of CD59 Using an Hairpin siRNA Expression Vector -- DISCUSSION -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGEMENT -- ABBREVIATIONS -- REFERENCES -- Points of Therapeutic Intervention along the Wnt Signaling Pathway in Hepatocellular Carcinoma -- INTRODUCTION -- THE WNT SIGNALING PATHWAY -- Overview of the Wnt Signaling -- The Wnt/β-catenin Pathway; Aberrant Activation of the Wnt/β-catenin Pathway in HCC -- TARGETING THE WNT/Β-CATENIN PATHWAY IN HCC -- Targeting the Upstream Components -- Endogenous Inhibitors of the Ligand/Receptor Complex -- Targeting Wnt Ligands and FZD Receptors -- Targeting the Dishevelled Protein -- Cellular Trafficking and Targets -- Targeting the β-catenin Destruction Complex -- Targeting the β-catenin/TCF Transcriptional Complex -- Pitfalls in Targeting the Wnt/β-catenin Pathway -- CONCLUSIONS AND PERSPECTIVES -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGMENT -- ABBREVIATIONS -- REFERENCES -- Collaboration of Epithelial Mesenchymal Transition and Cancer Stem Cells: Sinister Routes for Chemoresistant Recurrent Ovarian Cancer -- INTRODUCTION -- PATHOLOGY OF OVARIAN CANCER -- TRANSITION FROM EPITHELIAL TO MESENCHYMAL PHENOTYPE AND THE PROGRESSION OF CANCER -- EVIDENCE OF EMT IN OVARIAN CANCER -- STEM CELLS IN NORMAL OVARIES AND OVARIAN CANCER -- SPHERE FORMATION AND THE CANCER STEM CELL PHENOTYPE OF THE OVARY -- ASSOCIATION OF EMT AND CSCS: A MERGER FOR POTENTIAL CHEMORESISTANCE IN OVARIAN CANCER -- Cisplatin Induced EMT Generates Ovarian Cancer Stem-Like Cells: A Study on the OVCA 433 Cell Line as an Experimental Model -- NEW THERAPEUTIC APPROACHES AND CONCLUSION -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGEMENTS -- ABBREVIATIONS -- REFERENCES -- Oxaliplatin-mediated Inhibition of Survivin Increases Sensitivity of Head and Neck Squamous Cell Carcinoma Cell Lines to Paclitaxel -- INTRODUCTION -- MATERIALS AND METHODS -- Cell Culture -- Plasmid and Antisense Transfection Efficiency -- Drug Treatment -- MTT (methylthiazolyldiphenyl-tetrazolium bromide) Assay -- Western Blot Analysis -- Real-Time PCR -- TUNEL (Terminal Deoxyribonucleotidyl Transferase Mediated dUTP Nick End Labeling) Assay -- Statistical Analysis -- RESULTS; Detection of Survivin Gene Expression -- Effect of Paclitaxel and Oxaliplatin on Cell Growth and Survival -- Survivin Expression Reduces Paclitaxel-mediated Cytotoxicity -- Oxaliplatin Sensitizes Cancer Cells to Paclitaxel by Inhibiting Survivin -- Inhibition of Survivin by a siRNA Method Induces Paclitaxel-mediated Cell Death -- DISCUSSION -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGEMENTS -- ABBREVIATIONS -- REFERENCES -- Melatonin Inhibits the Growth of DMBA-induced Mammary Tumors by Regulating Estrogen Sulfatase Enzyme -- INTRODUCTION -- MATERIAL AND METHODS -- Animals and Housing Conditions -- Tumor Induction -- Experimental Design -- Surgical Treatments, Tumor Size and Number, Survival Rates and Autopsy Procedures -- Estrone Sulfate and Melatonin Treatments -- Measurement of Steroid Sulfatase Activity -- Measurement of mRNA Expression of Sulfatase -- Statistical Analysis -- RESULTS -- Histopathology of Mammary Tumors -- Evolution of Body Weight -- Tumor Growth -- Survival Probability -- Serum Estradiol Concentration and Uterine Weight -- Sulfatase Activity and Expression -- DISCUSSION -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGEMENTS -- REFERENCES -- Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis -- INTRODUCTION -- mTOR Strcture and Signaling Complexes -- mTOR Signaling Complexes -- mTORC1 -- mTORC2 -- mTOR Inhibitors -- The Role of mTOR Signaling Pathway in Cell Motility and Invasion -- mTORC1 Signaling in Cell Motility and Invasion -- mTORC2 Signaling in Cell Motility and Invasion -- Rapamycin and Tumor Metastases -- SUMMARY -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGMENTS -- REFERENCES -- Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors -- INTRODUCTION -- RESULTS AND DISCUSSION -- Chemistry -- Biochemistry; Interaction between Compound 1 (SCH-53870) and Ras: Preliminary Observations -- Nucleotide Exchange Inhibition Experiments with Compounds 1-17 -- Effect of Compounds 1-4 on Mammalian Cell Growth -- COMPUTATIONAL ANALYSIS -- Docking Calculations -- CONCLUSION -- MATERIALS AND METHODS -- Expression and Isolation of Proteins -- Measurement of GEF-Stimulated Guanine Nucleotide Exchange on p21 h-Ras -- Measurement of Dissociation Rate -- Two-Hybrid System -- Cell Cultures and Growth Conditions -- Docking Calculations -- SUPPLEMENTARY MATERIAL -- CONFLICT OF INTEREST -- DISCLOSURE -- ACKNOWLEDGMENTS -- ABBREVIATIONS -- REFERENCES -- SUBJECT INDEX
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