TY  - BOOK
AU  - Cooper,David S.
AU  - Durante,Cosimo
TI  - Thyroid Cancer: A Case-Based Approach
SN  - 9783319224015
AV  - RC648-665.2 
U1  - 616.99444 
PY  - 2015///
CY  - Cham
PB  - Springer International Publishing AG
KW  - Endocrinology
KW  - Electronic books
N1  - Intro -- Preface -- Contents -- Contributors -- Part I: Low Risk Differentiated Thyroid Cancer: Preoperative Diagnosis -- Chapter 1: A Patient with a Single Thyroid Nodule Suspicious for Follicular Neoplasm According to the Bethesda System for Reporting Thyroid Cytopathology: Molecular Evaluation -- Case Presentation -- Assessment and Literature Review -- Part I: Risk of Malignancy -- Limitations of Cytologic and Histologic Interpretation -- Demographic and Sonographic Features Predictive of Malignancy -- Part II: Molecular Evaluation -- Molecular Genetics in Thyroid Cancer -- Clinical Performance and Proposed Utility of Molecular Testing -- Afirma Gene Expression Classifier -- Management of the Case -- Clinical Pearls -- References -- Part II: Low Risk Differentiated Thyroid Cancer: Initial Management: Extent of Surgery and Use of Radioactive Iodine Therapy -- Chapter 2: A Case of a Small (1-2 cm) Papillary Thyroid Cancer in a Young Patient: Lobectomy Versus Total Thyroidectomy -- Case Presentation -- Assessment and Literature Review -- Prognostic Features -- Management Strategies -- Complications of Total Thyroidectomy -- Indications for Adjuvant Radioiodine Therapy -- Management of the Case -- Clinical Pearls/Pitfalls -- References -- Chapter 3: The Decision-Making Process for Prophylactic Central Neck Dissection in a Patient Presenting with an Indeterminate Thyroid Nodule on Cytology Assessment: Role of Preoperative Ultrasound and Molecular Marker Testing -- Case Presentation -- Background -- Preoperative Evaluation -- Ultrasound Evaluation -- Molecular Marker Testing -- Management -- Prophylactic CND for Small-Volume Microscopic Lymph Node Metastasis (cN0) -- Molecular Markers as a Guide for Surgical Extent -- Summary -- References -- Chapter 4: Incidentally Discovered Micropapillary Thyroid Cancer -- Case Presentation; Assessment and Literature Review -- Definition -- Prevalence -- Retrospective Studies -- Observational Studies -- Incidental Versus Non-incidental Tumors -- BRAF -- Management of the Case -- BRAF -- Completion Thyroidectomy or Fine-Needle Aspiration of the Remaining Nodules -- Radioiodine -- Thyroid Hormone Suppression -- Clinical Pearls/Pitfalls -- References -- Chapter 5: Completion Thyroidectomy in a Patient with Low-Risk Papillary Cancer -- The Case -- Assessment and Literature Review -- Back to the Patient -- Clinical Pearls -- References -- Chapter 6: A Case of Multifocal Papillary Thyroid Microcarcinoma -- Case Presentation -- Diagnosis/Assessment -- Postoperative Management -- Outcome -- Literature Review -- Epidemiology -- Diagnosis -- Risk Factors for Aggressive Disease -- Treatment of Multifocal PTMC -- Follow-Up -- Summary -- Clinical Pearls/Pitfalls -- References -- Chapter 7: A Papillary Thyroid Cancer with Minimal Extra-thyroidal Extension -- Case Presentation -- Assessment and Literature Review -- Definition and Prevalence -- Comparison of Minimal with Major Extra-thyroidal Extension -- Survival with Minimal Extra-thyroidal Extension -- Recurrence Risk with Minimal Extra-thyroidal Extension -- Management of the Case -- Did Our Patient Need Completion Thyroidectomy? -- Is a Postoperative Thyroglobulin Useful in Determining Further Treatment? -- Will Radioiodine Remnant Ablation Be Helpful? -- What Should the Thyrotropin (TSH) Target Be? -- What Do Thyroid Cancer Guidelines Say About Minimal Extra- thyroidal Extension? -- Case Progress -- Clinical Pearls/Pitfalls -- References -- Chapter 8: A Case of a Papillary Thyroid Cancer with Lymph Node Metastases Found on Prophylactic Central Neck Dissection (Subclinical Disease, Micrometastases) -- Case Discussion -- Presentation -- Diagnosis -- Surgical Management; Assessment During First Postoperative Year -- Surveillance from One Through Six Postoperative Years -- Literature Review -- Postoperative Outcome in Woolner's "Occult" PTC -- What Would the ATA Guidelines Advise for the Patient Discussed? -- How Therefore Should a Thyroidologist Advise Such a Patient in 2015? -- Clinical Pearls/Pitfalls -- References -- Chapter 9: Papillary Thyroid Cancer with Central Neck Lymph Node Metastases -- Case Presentation -- Diagnosis/Assessment -- Literature Review -- Classification of Lymph Node Disease -- Epidemiology of N1 Disease in Patients with Micro-PTC -- Prognosis of N1 Disease in Patients with Micro-PTC -- Does RAI Adjuvant Treatment Reduce the Risk of Disease Recurrence in T1aN1 Disease? -- Management Considerations and Outcome -- Clinical Pearls/Pitfalls -- References -- Chapter 10: A Patient with a Large Minimally Invasive Follicular Thyroid Cancer -- Case Presentation -- Literature Review -- Definition -- Molecular Analysis -- Prognosis -- Treatment -- Clinical Pearls/Pitfalls -- References -- Chapter 11: A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer -- Case Presentation -- Literature Review -- Back to the Patient -- Clinical Pearls -- References -- Chapter 12: A Child with Papillary Thyroid Cancer and Locally Advanced Disease but No Distant Metastasis -- Introduction -- Case Presentation -- Assessment and Literature Review -- Back to the Case -- Clinical Pearls -- References -- Part III: Low Risk Differentiated Thyroid Cancer: Postoperative Follow-Up -- Chapter 13: A Patient with Papillary Thyroid Cancer and Biochemical Evidence of Disease at the One-Year Follow-Up Visit -- Case Presentation -- Literature Review -- What Is the Role of Serum Tg Measurement in Patients Who Have not Undergone Radioiodine Remnant Ablation?; What Is the Role of Neck US or Other Imaging Techniques? -- What Are the Criteria for the Absence of Persistent Tumor? -- Back to the Patient -- Clinical Pearls -- References -- Chapter 14: Low but Detectable Suppressed Thyroglobulin Levels in the Follow-Up of Differentiated Thyroid Cancer -- Case Presentation -- Assessment and Literature Review -- Risk Stratification -- Lymph Node Involvement -- Radioiodine Remnant Ablation -- TSH Suppression -- Case Management -- Clinical Pearls/Pitfalls -- References -- Chapter 15: A Patient with Papillary Thyroid Carcinoma and Biochemical Evidence of Disease at Follow-Up Visits and Increasing Serum Tg Values at the Follow-Up Assessments -- Case Presentation -- Assessment and Literature Review -- Therapies for Metastatic PTC -- Representative Molecular-Target Agents for RAI-Refractory PTC -- Prognosis of DTC Patients with RAI-Refractory Metastases -- Thyroglobulin-Doubling Time -- Management of the Case -- Initial Management After Surgery -- Management After Detection of RAI-Refractory Recurrences -- Clinical Pearls -- References -- Chapter 16: A Young Patient with Recurrent Lymph Node Involvement: Imaging, Cytology, and Thyroglobulin Washout -- Case Presentation -- Literature Review -- Back to the Patient -- Clinical Pearls/Pitfalls -- References -- Part IV: Low Risk Differentiated Thyroid Cancer: Special Issues -- Chapter 17: Papillary Thyroid Carcinoma Diagnosed During Pregnancy -- Case Presentation -- Assessment and Literature Review -- Back to the Patient -- Clinical Pearls/Pitfalls -- References -- Chapter 18: Risks of Thyroid Hormone Suppression for Differentiated Thyroid Cancer in the Elderly -- Case Presentation -- Assessment and Literature Review -- Prevalence -- Efficacy of Thyroid Hormone Suppression Therapy -- Recommendations for Serum TSH Suppression Goals; Adverse Effects Associated with Suppressive T4 Therapy in the Elderly -- Cardiovascular Disease -- Dysrhythmias -- Cardiovascular Mortality -- Bone Health -- Bone Mineral Density and Fracture Risk -- Treatment -- Management of Patient -- Clinical Pearls/Pitfalls -- References -- Chapter 19: A Patient in Whom One Pathologist Says She Has Cancer, and Another Says that the Lesion Is Benign -- Case Presentation -- Assessment and Literature Review -- General Considerations -- Clinical Presentation -- Treatment -- Surgical Pathology -- Prognosis -- Clinical Pearls/Pitfalls -- References -- Chapter 20: A Case with Postsurgical Hypoparathyroidism -- Case Presentation -- Assessment and Literature Review -- Definition and Prevalence -- Predictors of Post-thyroidectomy Hypocalcemia -- Management of the Case -- Therapy -- Long-Term Follow-Up -- Management of the Case -- Clinical Pearls/Pitfalls -- References -- Chapter 21: A Patient with Postsurgical Recurrent Laryngeal Nerve Damage and Nerve Monitoring -- Case Presentation -- Assessment and Literature Review -- Mechanism of Nerve Injury -- Evaluating Recurrent Laryngeal Nerve Function Intraoperatively -- Clinical Manifestations -- Management -- Voice and Swallowing Therapy -- Surgical Management -- Back to the Patient: Outcome -- Clinical Pearls -- References -- Part V: High Risk Differentiated Thyroid Cancer: The Need for Additional Therapy -- Chapter 22: A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with Nodal Metastases Detected During Follow-Up in a Younger Patient -- The Case -- Assessment and Literature Review -- Back to the Patient -- Clinical Pearls -- References -- Chapter 23: A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with Nodal Metastases in an Older Patient -- The Case -- Assessment and Literature Review -- Back to the Patient; Clinical Pearls
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